Nickel and Samarium-doped strontium ferrite nanoparticles were synthesised using the sol-gel autocombustion method. The micro-structural characteristics of the ferrite were investigated using X-ray diffraction (XRD) and eld emission scanning electron microscopy (FE-SEM). The particle size was determined to be between 30 and 60 nm. The vibrating sample magnetometer (VSM) revealed a strong magnetization with paramagnetic behaviour, and the existence of all elements was veri ed by energy dispersive X-ray spectroscopy (EDS). According to the BET adsorption isotherm, total surface area ranges from 13.77 m 2 g -1 to 28.49 m 2 g -1 . At P/Po (0.99), the total pore volume ranges from 0.02 cm 3 g -1 to 0.04 cm 3 g -1 . The average pore width ranged from 3.5 nm to 6.5 nm, and the isotherm demonstrates type III with an H 3 hysteresis loop. The material shows 84% thermal stability and these synthesized nanoparticles are showing activity against both Gram Positive and Gram-Negative bacterial pathogens.