Exploring the DNA binding efficacy of Cobalt(II) and Copper(II) complexes of hydroxamic acids and explicating their anti-cancer propensity

Thakur, Yamini; Agrawal, Rainy; Siddiqi, Mohammad Khursheed; Mohapatra, Eli; Khan, Rizwan Hasan; Tripathi, Mamta

doi:10.1016/j.molstruc.2019.07.099

Cited by 16 publications

(7 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The minor groove binding mode of metal complexes with the ct‐DNA and its anticancer activity were proved in previous study, indicating there was a positive relationship of the binding ability between metal complexes with DNA base pairs and its anticancer activity [11] . Base on the results of the minor groove binding mode of costunolide with ct‐DNA, the effects of costunolide on apoptosis were detected by cell biology technology in this study.…”

Section: Resultssupporting

confidence: 53%

“…DNA has a maximum absorption peak at approximately 260 nm due to chromophoric groups in purine (A and G) and pyrimidine (C and T) moieties responsible for the electronic transitions [2] . Both hypochromism and hyperchromism are the spectral features of DNA double helix structure [1,11] . When small molecule combined with DNA through the groove binding mode, the small molecule‐ct‐DNA complex will appear hypochromic or hyperchromic effect with the peak position shift smaller or no shift [1] .…”

Section: Resultsmentioning

confidence: 99%

“…DNA always suffers from various types of damage, which adversely affects the integrity and stability of the entire genome [8,9] . If DNA is damaged severely, cell death or apoptosis will occur [9–11] . Apoptosis is the autonomous cell death determined by genes.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Exploring the Potential Mechanism of Costunolide‐Induced MCF‐7 Cells Apoptosis by Multi‐Spectroscopy, Molecular Docking and Cell Experiments

Liú

Zeng

et al. 2021

Chemistry & Biodiversity

View full text Add to dashboard Cite

Breast cancer is one of the most common cancer with high morbidity and mortality in women. This study aimed to explore the potential mechanism of costunolide inducing MCF‐7 cells apoptosis by multi‐spectroscopy, molecular docking, and cell experiments. The results manifested that costunolide interacted with calf thymus DNA (ct‐DNA) in a spontaneous manner, and the minor groove as the preferential binding mode. Furthermore, costunolide inhibited cell proliferation and colony formation. Hoechst 33258 staining showed that cell apoptosis induced by costunolide might be related to DNA damage. The apoptosis mechanism relied on regulating the protein expression of Bax, Bcl‐2, p53, Caspase‐3 and the activation of p38MAPK and nuclear factor κB (NF‐κB) pathways. This study will provide some experimental basis and potential therapeutic strategy for breast cancer treatment.

show abstract

Section: Resultssupporting

confidence: 53%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Exploring the Potential Mechanism of Costunolide‐Induced MCF‐7 Cells Apoptosis by Multi‐Spectroscopy, Molecular Docking and Cell Experiments

Liú

Zeng

et al. 2021

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…The compounds I-III successfully bounded to a minor groove of ct-DNA in an A-T rich region as show in Fig. 8A, corroborating with other authors [49]. The geometry of interactions is stabilized by hydrophobic interactions in minor groove of ct-DNA region (Fig.…”

Section: Computational Analysis Of Complexes I-iiisupporting

confidence: 89%

Síntese e avaliação do potencial antitumoral de complexos de cobre(II) e níquel(II) contendo ligantes de interesse biológico

Ramos¹

View full text Add to dashboard Cite

Aos meus pais Antônio José e Mônica, meuesposo Thiago e a toda minha família por serem meu Porto Seguro. Uma luz em dias nublados. Amo vocês. AgradecimentosA Deus, porque dele vem a minha força e é nele que deposito todas as minhas esperanças "(...) nos gloriamos até nas tribulações. Pois, sabemos que a tribulação produz a paciência; a paciência prova a fidelidade; e a fidelidade comprovada, produz a esperança (Romanos 5: 3-5). Durante todos esses anos de muito trabalho e dedicação, eu descobri que a ciência cura, traz esperança e nos tira da nossa zona de conforto em busca de tantas respostas e soluções, mas também descobri que foi Deus que me guiou até aqui. Ao meu orientador Dr. Wendell pelo seu profissionalismo e comprometimento com a pesquisa, sua orientação e amizade foram fundamentais para concluir essa etapa e continuar acreditando em dias melhores. Aos meus amigos e colegas do Lasfar Mônica, Drielly, Janaína, Letícia, Wesley, Rafael e Maurício, obrigado pela leveza, conversas, trocas cientificas, risadas, cafés e congressos. Foi muito saudável dividir o mesmo espaço com todos vocês, não tínhamos competição uns com os outros, mas uma vontade de juntos fazer ciência e conseguimos. Aos alunos de iniciação científica Daniel e Milena que dividiram comigo muitos experimentos. Obrigada pelo tempo de vocês, esforço e dedicação. Vocês foram fundamentais nessa jornada.As alunas de pós-graduação Ana Clara e Flávia pelas inúmeras conversas, parceria e amizade, sempre compartilhamos das mesmas aflições e angústias.Aos meus pais Antônio e Mônica, pessoas maravilhosas de um coração enorme.Todos os conselhos e apoio foram essenciais para encarar e resolver os problemas que surgiram ao longo desses anos. Vocês são meu exemplo, minha admiração, meu porto seguro, que sorte eu tenho. Amo vocês.Ao meu esposo Thiago pela paciência e por diversas vezes entender as minhas renúncias e superações. Ter pessoas certas ao nosso lado que acreditam nos nossos sonhos e nos incentivam a continuar é raro. Obrigada por ser essa pessoa, pelo seu companheirismo, amizade, cumplicidade e amor. Eu te amo muito.A minha irmã Moniele que nos meus dias de dúvidas e cansaço esteve ao meu lado consolando com uma palavra amiga e um bom café.A minha linda e incrível família. Aos meus avós, em especial ao meu avô João Campos (in memoriam), que foi muito especial na minha trajetória acadêmica com seus sábios ensinamentos, se um dia eu duvidei da minha capacidade, Ele jamais.A todos os professores do Instituto de Química pelos ensinamentos, em especial das disciplinas de Química Inorgânica, pois com maestria compartilharam seus conhecimentos. A secretária Mayta Peixoto e o coordenador Dr. Rodrigo Muñoz do Programa de Pós Graduação em Química (PPGQUI), pela presteza e orientação durante todo o processo do doutorado. As funcionárias Elimar e Deuzuite por manterem nosso lugar de trabalho limpo e que por muitos meses dividiram comigo no horário do almoço histórias cheias de risadas. Aos técnicos Roni Santos e Magayver Portela do Laboratório Multiusuário do I...

show abstract

“…Many studies have shown that cobalt‐containing complexes can be used in PDT because they can photocleave DNA in vitro and bind to different chromophoric ligands and act as PSs (60,61). For instance, the dark and light cytotoxicity of cobalt(III) curcumin complexes with different N , N , N,N ‐tripodal ligands (Fig.…”

Section: Cobaltmentioning

confidence: 99%

Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer^†

Smith

Days

Alajroush

et al. 2021

Photochem & Photobiology

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is a medicinal tool that uses a photosensitizer and a light source to treat several conditions, including cancer. PDT uses reactive oxygen species such as cytotoxic singlet oxygen (1O2) to induce cell death in cancer cells. Chemotherapy has historically utilized the cytotoxic effects of many metals, especially transition metal complexes. However, chemotherapy is a systemic treatment so all cells in a patient’s body are exposed to the same cytotoxic effects. Transition metal complexes have also shown high cytotoxicity as PDT agents. PDT is a potential localized method for treating several cancer types by using inorganic complexes as photosensitizing agents. This review covers several in vitro and in vivo studies, as well as clinical trials that reported on the anticancer properties of inorganic pharmaceuticals used in PDT against different types of cancer.

show abstract

Exploring the DNA binding efficacy of Cobalt(II) and Copper(II) complexes of hydroxamic acids and explicating their anti-cancer propensity

Cited by 16 publications

References 86 publications

Exploring the Potential Mechanism of Costunolide‐Induced MCF‐7 Cells Apoptosis by Multi‐Spectroscopy, Molecular Docking and Cell Experiments

Exploring the Potential Mechanism of Costunolide‐Induced MCF‐7 Cells Apoptosis by Multi‐Spectroscopy, Molecular Docking and Cell Experiments

Síntese e avaliação do potencial antitumoral de complexos de cobre(II) e níquel(II) contendo ligantes de interesse biológico

Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer^†

Contact Info

Product

Resources

About

Exploring the DNA binding efficacy of Cobalt(II) and Copper(II) complexes of hydroxamic acids and explicating their anti-cancer propensity

Cited by 16 publications

References 86 publications

Exploring the Potential Mechanism of Costunolide‐Induced MCF‐7 Cells Apoptosis by Multi‐Spectroscopy, Molecular Docking and Cell Experiments

Exploring the Potential Mechanism of Costunolide‐Induced MCF‐7 Cells Apoptosis by Multi‐Spectroscopy, Molecular Docking and Cell Experiments

Síntese e avaliação do potencial antitumoral de complexos de cobre(II) e níquel(II) contendo ligantes de interesse biológico

Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer†

Contact Info

Product

Resources

About

Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer^†