Exploring the frostbite healing potential of hyaluronic acid based hydrogel of Manuka honey through<i>in-silico</i>antithrombotic and anti-platelet studies of major phytoconstituents and<i>in-vivo</i>evaluation in Wistar rat model

Joshi, Kumud; Mazumder, Bhaskar; Chattopadhyay, Pronobesh; Goyary, Danswrang; Das, Madhubanti; Dwivedi, Sanjai K.

doi:10.1080/03639045.2021.1989459

Cited by 2 publications

(2 citation statements)

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“…Its action in tissue healing and renewal is based on reducing inflammatory cell response and, concurrently, activating cytokine production in the wound area, resulting in the proliferation of epithelial cells. On this basis, various formulations based on honey, and in combination with other substances such as hyaluronic acid and zein coatings, have been tested [90][91][92][93].…”

Section: Php?ids[]=saandids[]=egandids[]=ptandids[]=b Randids[]=it (A...mentioning

confidence: 99%

Honey’s Antioxidant and Antimicrobial Properties: A Bibliometric Study

et al. 2023

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Research attention has been drawn to honey’s nutritional status and beneficial properties for human health. This study aimed to provide a bibliometric analysis of honey’s antioxidant and antimicrobial properties. The research advancements within this field from 2001 to 2022 were addressed using the Scopus database, R, and VOSviewer. Of the 383 results, articles (273) and reviews (81) were the most common document types, while the annual growth rate of published manuscripts reached 17.5%. The most relevant topics about honey’s antimicrobial and antioxidant properties were related to the agricultural and biological sciences, biochemistry, and pharmacology. According to a keyword analysis, the most frequent terms in titles, abstracts, and keywords were honey, antimicrobial, antioxidant, bee, propolis, phenolic compounds, wound, antibacterial, anti-inflammatory, and polyphenols. A trend topic analysis showed that the research agenda mainly encompassed antioxidants, pathogens, and anti-infection and chemical agents. In a co-occurrence analysis, antioxidants, anti-infection agents, and chemistry were connected to honey research. The initial research focus of this domain was primarily on honey’s anti-inflammatory and antineoplastic activity, wound healing, and antibacterial agents. The research agenda was enriched in the subsequent years by pathogens, propolis, oxidative stress, and flavonoids. It was possible to pinpoint past trends and ongoing developments and provide a valuable insight into the field of honey research.

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Section: Php?ids[]=saandids[]=egandids[]=ptandids[]=b Randids[]=it (A...mentioning

confidence: 99%

Honey’s Antioxidant and Antimicrobial Properties: A Bibliometric Study

et al. 2023

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“…Treatment with HA activates Nrf2 and induces Nrf2-target genes in bovine chondrocytes and human breast cancer cells, with increased phosphorylation of AKT or higher levels of p62, which competes with Nrf2 for binding to Keap1 ( Komatsu et al, 2010 ), correlating with Nrf2 activation ( Choi et al, 2022 ; Onodera et al, 2015 ; Ryoo et al, 2018 ). In addition, a hydrogel formulation of HA increased the levels of Nrf2 in frostbite-wounded skin tissues of Wistar rats ( Joshi et al, 2021 ). To our knowledge, the possibility that Nrf2 activation may also occur in macrophages exposed to HA has not been explored.…”

Section: Endogenous Nrf2 Activators In the Tumor Immune Microenvironmentmentioning

confidence: 99%

Nrf2 in TIME: The Emerging Role of Nuclear Factor Erythroid 2-Related Factor 2 in the Tumor Immune Microenvironment

Feng

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Dinkova‐Kostova

2023

Molecules and Cells

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Nuclear factor erythroid 2-related factor 2 (Nrf2) mediates the cellular antioxidant response, allowing adaptation and survival under conditions of oxidative, electrophilic and inflammatory stress, and has a role in metabolism, inflammation and immunity. Activation of Nrf2 provides broad and long-lasting cytoprotection, and is often hijacked by cancer cells, allowing their survival under unfavorable conditions. Moreover, Nrf2 activation in established human tumors is associated with resistance to chemo-, radio-, and immunotherapies. In addition to cancer cells, Nrf2 activation can also occur in tumor-associated macrophages (TAMs) and facilitate an anti-inflammatory, immunosuppressive tumor immune microenvironment (TIME). Several cancer cell-derived metabolites, such as itaconate, L-kynurenine, lactic acid and hyaluronic acid, play an important role in modulating the TIME and tumor-TAMs crosstalk, and have been shown to activate Nrf2. The effects of Nrf2 in TIME are context-depended, and involve multiple mechanisms, including suppression of pro-inflammatory cytokines, increased expression of programmed cell death ligand 1 (PD-L1), macrophage colony-stimulating factor (M-CSF) and kynureninase, accelerated catabolism of cytotoxic labile heme, and facilitating the metabolic adaptation of TAMs. This understanding presents both challenges and opportunities for strategic targeting of Nrf2 in cancer.

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Exploring the frostbite healing potential of hyaluronic acid based hydrogel of Manuka honey throughin-silicoantithrombotic and anti-platelet studies of major phytoconstituents andin-vivoevaluation in Wistar rat model

Cited by 2 publications

References 21 publications

Honey’s Antioxidant and Antimicrobial Properties: A Bibliometric Study

Honey’s Antioxidant and Antimicrobial Properties: A Bibliometric Study

Nrf2 in TIME: The Emerging Role of Nuclear Factor Erythroid 2-Related Factor 2 in the Tumor Immune Microenvironment

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