Exploring the influence factors and improvement strategies of drug polymorphic transformation combined kinetic and thermodynamic perspectives during the formation of nanosuspensions

Meng, Tao; Qiao, Fangxia; Ma, Shanshan; Li, Li; Hou, Yanhui; Yang, Jianhong

doi:10.1080/03639045.2022.2061988

Cited by 5 publications

(2 citation statements)

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“…In the context of the "top-down" approach, milling processes are primarily propelled by factors such as cavitation forces, shear forces, and inter-particle collisions within the chamber. The mechanical energy's pressure can disturb crystal lattices, potentially leading to the transformation of the drug crystal into an amorphous state or a metastable form [30]. The process of polymorphic transformation during mechanical milling typically involves two steps: (1) the amorphization of the impacted fraction and (2) rapid recrystallization guided by surrounding crystallites, favoring the γ or α forms [31].…”

Section: Polymorphism Transformation In the Top-down Methodsmentioning

confidence: 99%

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Herbal Medicine Nanocrystals: A Potential Novel Therapeutic Strategy

Guo,

Qin,

Wang

et al. 2023

Molecules

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Herbal medicines have gained recognition among physicians and patients due to their lower adverse effects compared to modern medicines. They are extensively used to treat various diseases, including cancer, cardiovascular issues, chronic inflammation, microbial contamination, diabetes, obesity, and hepatic disorders, among others. Unfortunately, the clinical application of herbal medicines is limited by their low solubility and inadequate bioavailability. Utilizing herbal medicines in the form of nanocrystals (herbal medicine nanocrystals) has shown potential in enhancing solubility and bioavailability by reducing the particle size, increasing the specific surface area, and modifying the absorption mechanisms. Multiple studies have demonstrated that these nanocrystals significantly improve drug efficacy by reducing toxicity and increasing bioavailability. This review comprehensively examines therapeutic approaches based on herbal medicine nanocrystals. It covers the preparation principles, key factors influencing nucleation and polymorphism control, applications, and limitations. The review underscores the importance of optimizing delivery systems for successful herbal medicine nanocrystal therapeutics. Furthermore, it discusses the main challenges and opportunities in developing herbal medicine nanocrystals for the purpose of treating conditions such as cancer, inflammatory diseases, cardiovascular disorders, mental and nervous diseases, and antimicrobial infections. In conclusion, we have deliberated regarding the hurdles and forthcoming outlook in the realm of nanotoxicity, in vivo kinetics, herbal ingredients as stabilizers of nanocrystals, and the potential for surmounting drug resistance through the utilization of nanocrystalline formulations in herbal medicine. We anticipate that this review will offer innovative insights into the development of herbal medicine nanocrystals as a promising and novel therapeutic strategy.

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Section: Polymorphism Transformation In the Top-down Methodsmentioning

confidence: 99%

“…Near Tg, recrystallization may manifest on the surface due to heightened molecular mobility, surpassing that within the bulk. Additionally, temperatures exceeding Tg tend to induce the emergence of new crystal forms [30,33].…”

Section: Polymorphism Transformation In the Top-down Methodsmentioning

confidence: 99%