Exploring the inhibitory effect of membrane tension on cell polarization

Wang, Weikang; Tao, Kuan; Wang, Jing; Yang, Gen; Ouyang, Qi; Wang, Yugang; Zhang, Lei; Liu, Feng

doi:10.1371/journal.pcbi.1005354

Cited by 33 publications

(26 citation statements)

References 71 publications

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“…Compared to non-CSCs, CSCs have lower cell membrane tension and exhibit significant shape deformation in response to stimuli. Increase in membrane tension by immersing CSCs in hypotonic medium leads to a decrease in polarized CSCs [ 115 ]. Because cell polarity is essential for asymmetric division and migration [ 116 , 117 ], CSCs would benefit from increased fatty acid unsaturation in lowering membrane tension and preventing symmetric division or loss of pluripotency.…”

Section: Alterations In Lipid Metabolism In Cscsmentioning

confidence: 99%

Emerging role of lipid metabolism alterations in Cancer stem cells

Man

Chen

et al. 2018

J Exp Clin Cancer Res

181

149

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BackgroundCancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the bulk of tumor cells, CSCs or TICs are refractory to traditional therapy and are responsible for relapse or disease recurrence in cancer patients. Stem cells have distinct metabolic properties compared to differentiated cells, and metabolic rewiring contributes to self-renewal and stemness maintenance in CSCs.Main bodyRecent advances in metabolomic detection, particularly in hyperspectral-stimulated raman scattering microscopy, have expanded our knowledge of the contribution of lipid metabolism to the generation and maintenance of CSCs. Alterations in lipid uptake, de novo lipogenesis, lipid droplets, lipid desaturation, and fatty acid oxidation are all clearly implicated in CSCs regulation. Alterations on lipid metabolism not only satisfies the energy demands and biomass production of CSCs, but also contributes to the activation of several important oncogenic signaling pathways, including Wnt/β-catenin and Hippo/YAP signaling. In this review, we summarize the current progress in this attractive field and describe some recent therapeutic agents specifically targeting CSCs based on their modulation of lipid metabolism.ConclusionIncreased reliance on lipid metabolism makes it a promising therapeutic strategy to eliminate CSCs. Targeting key players of fatty acids metabolism shows promising to anti-CSCs and tumor prevention effects.

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Section: Alterations In Lipid Metabolism In Cscsmentioning

confidence: 99%

Emerging role of lipid metabolism alterations in Cancer stem cells

Man

Chen

et al. 2018

J Exp Clin Cancer Res

181

149

View full text Add to dashboard Cite

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“…To address whether the quantitative differences in medial myosin pulses observed in our experiments are sufficient to generate different outcomes for delaminating cells and their neighbors, we propose a phase-field model to simulate the dynamics of the neuroblast delamination process. The phase-field method has been successfully used in modeling single-cell events, such as cell membrane bending and cell migration (Du et al, 2004;Shao et al, 2012;Wang et al, 2017). Here, we extend this approach to study the morphodynamics of a multicellular system.…”

Section: Medial Myosin Pulses Are Required For the Apical Constrictiomentioning

confidence: 99%

Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts

Xue

Shaobo

et al. 2017

Development

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Cell delamination is a conserved morphogenetic process important for the generation of cell diversity and maintenance of tissue homeostasis. Here, we used Drosophila embryonic neuroblasts as a model to study the apical constriction process during cell delamination. We observe dynamic myosin signals both around the cell adherens junctions and underneath the cell apical surface in the neuroectoderm. On the cell apical cortex, the nonjunctional myosin forms flows and pulses, which are termed medial myosin pulses. Quantitative differences in medial myosin pulse intensity and frequency are crucial to distinguish delaminating neuroblasts from their neighbors. Inhibition of medial myosin pulses blocks delamination. The fate of a neuroblast is set apart from that of its neighbors by Notch signaling-mediated lateral inhibition. When we inhibit Notch signaling activity in the embryo, we observe that small clusters of cells undergo apical constriction and display an abnormal apical myosin pattern. Together, these results demonstrate that a contractile actomyosin network across the apical cell surface is organized to drive apical constriction in delaminating neuroblasts.

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“…Elongated cellular morphology due to nutrient depletion may also be considered. The incorporation of cell morphological change may need to shift the current simple computational approach to a more involved numerical method, such as the level set or phase field methods [ 44 ], and the computational cost will increase drastically. Therefore, a more feasible first step would be using the current framework but making the directional growth possible as in [ 45 ], without considering the detailed cell shape change.…”

Section: Discussionmentioning

confidence: 99%

A modeling study of budding yeast colony formation and its relationship to budding pattern and aging

Wang

Chou

2017

PLoS Comput Biol

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Budding yeast, which undergoes polarized growth during budding and mating, has been a useful model system to study cell polarization. Bud sites are selected differently in haploid and diploid yeast cells: haploid cells bud in an axial manner, while diploid cells bud in a bipolar manner. While previous studies have been focused on the molecular details of the bud site selection and polarity establishment, not much is known about how different budding patterns give rise to different functions at the population level. In this paper, we develop a two-dimensional agent-based model to study budding yeast colonies with cell-type specific biological processes, such as budding, mating, mating type switch, consumption of nutrients, and cell death. The model demonstrates that the axial budding pattern enhances mating probability at an early stage and the bipolar budding pattern improves colony development under nutrient limitation. Our results suggest that the frequency of mating type switch might control the trade-off between diploidization and inbreeding. The effect of cellular aging is also studied through our model. Based on the simulations, colonies initiated by an aged haploid cell show declined mating probability at an early stage and recover as the rejuvenated offsprings become the majority. Colonies initiated with aged diploid cells do not show disadvantage in colony expansion possibly due to the fact that young cells contribute the most to colony expansion.

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Exploring the inhibitory effect of membrane tension on cell polarization

Cited by 33 publications

References 71 publications

Emerging role of lipid metabolism alterations in Cancer stem cells

Emerging role of lipid metabolism alterations in Cancer stem cells

Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts

A modeling study of budding yeast colony formation and its relationship to budding pattern and aging

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