Exploring the molecular pathways and therapeutic implications of angiogenesis in neuropathic pain

Sharma, Aditi; Behl, Tapan; Sharma, Lalit Kumar; Shah, Om Prakash; Yadav, Shivam; Sachdeva, Monika; Rashid, Summya; Bungău, Simona; Bustea, Cristiana

doi:10.1016/j.biopha.2023.114693

Cited by 8 publications

(2 citation statements)

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“…This includes targeting specific receptors, ion channels, or signaling pathways involved in pain transmission and modulation. 118,119 Overall, pharmacological methods of pain management should be used judiciously and tailored to individual patient needs to achieve optimal pain relief and improve quality of life.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Methods of Pain Management: Narrative Review of Medication Used

Alorfi¹

2023

IJGM

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Background: Pain management is a critical aspect of healthcare, aimed at alleviating discomfort and improving the quality of life for individuals experiencing acute or chronic pain. Pharmacological methods constitute a primary approach to pain management, including a diverse array of drugs that work through different mechanisms. Aim: Identifying medications commonly employed in pain management, focusing on their mechanism of actions, uses, efficacy and pharmacological applications. Methods: The methodology involved a systematic search of scientific literature using various databases, including PubMed, Scopus, and Google Scholar. Relevant articles published between 2000 and 2023 were screened for inclusion. The selected studies encompassed original research, review articles, therapeutic guidelines and randomized controlled trials. Results: The findings of this review suggest that a multimodal approach combining various analgesics can enhance pain relief while minimizing adverse effects. It emphasizes the importance of assessing pain intensity, determining the underlying etiology, and utilizing evidence-based guidelines to optimize pain management outcomes. Conclusion: Pharmacological methods of pain management are an essential component of pain management strategies to achieve optimal pain relief while minimizing adverse effects. The article concludes with a discussion on emerging trends and future directions in pharmacological pain management, including novel drug targets and advances in drug delivery systems.

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Section: Discussionmentioning

confidence: 99%

Pharmacological Methods of Pain Management: Narrative Review of Medication Used

Alorfi¹

2023

IJGM

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“…Angiogenesis is evident in inflammation of neurons. In spinal cord, central neuroinflammation and angiogenesis occurs in conjunction, which is related to vascular endothelial growth factor (VEGF) pathway 19 . Therefore, we focused on the regulation of inflammatory factors and angiogenesis‐related factors by SPP1.…”

Section: Introductionmentioning

confidence: 99%

Silencing of secreted phosphoprotein 1 attenuates sciatic nerve injury‐induced neuropathic pain: Regulating extracellular signal‐regulated kinase and neuroinflammatory signaling pathways

Xie,

Lu,

et al. 2024

Immunity Inflam & Disease

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BackgroundNeuropathic pain (NP) is a chronic pathological pain that affects the quality of life and is a huge medical burden for affected patients. In this study, we aimed to explore the effects of secreted phosphoprotein 1 (SPP1) on NP.MethodsWe established a chronic constriction injury (CCI) rat model, knocked down SPP1 via an intrathecal injection, and/or activated the extracellular signal‐regulated kinase (ERK) pathway with insulin‐like growth factor 1 (IGF‐1) treatment. Pain behaviors, including paw withdrawal threshold (PWT), paw withdrawal latency (PWL), lifting number, and frequency, were assessed. After sacrificing rats, the L4‐L5 dorsal root ganglion was collected. Then, SPP1 levels were determined using quantitative polymerase chain reaction (qPCR) and western blot analysis. The levels of interleukin (IL)‐1β, tumor necrosis factor (TNF)‐α, IL‐6, IL‐10, epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and transforming growth factor (TGF)‐β were determined using qPCR and enzyme‐linked immunosorbent assay. The levels of ERK pathway factors were determined via western blot analysis.ResultsWe found that CCI decreased PWT and PWL, increased the lifting number and frequency, and upregulated SPP1 levels. The loss of SPP1 reversed these CCI‐induced effects. Additionally, CCI upregulated IL‐1β, TNF‐α, IL‐6, EGF, and VEGF levels, downregulated TGF‐β levels, and activated the ERK pathway, while silencing of SPP1 abrogated these CCI‐induced effects. Moreover, IGF‐1 treatment reversed the effects of SPP1 loss.ConclusionsThe data indicate that silencing SPP1 attenuates NP via inactivation of the ERK pathway, suggesting that SPP1 may be a promising target for NP treatment.

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