Exploring the multifaceted role of TGF-β signaling in diabetic complications

Behl, Tapan; Gupta, Amit; Sehgal, Aayush; Singh, Sukhbir; Sharma, Neelam; Garg, Madhukar; Bhatia, Saurabh; Al‐Harrasi, Ahmed; Aleya, Lotfi; Bungău, Simona

doi:10.1007/s11356-022-19499-y

Cited by 6 publications

(3 citation statements)

References 78 publications

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“…FoxO proteins play an important role in cell survival, proliferation, apoptosis and energy metabolism (Graves & Milovanova, 2019). FoxO has been found to participate in the activation of pro‐inflammatory cytokines (Behl et al, 2022). A previous study revealed that FoxO dephosphorylation induced activation of MuRf1 and Atrogin1 in skeletal muscle cells (Zhou et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Exploring the therapeutic mechanisms of Sijunzi decoction in the treatment of sarcopenia: Key targets and signaling pathways

Dai,

Wang,

Jiang

et al. 2023

Biomedical Chromatography

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Sarcopenia, an age‐associated condition, negatively impacts the quality of life. This study investigates the mechanism of Sijunzi decoction (SJZD), a traditional Chinese formula, against sarcopenia. Active compounds and potential targets of SJZD for sarcopenia were gathered from databases. Hub targets were identified using protein–protein interaction networks, with GO and KEGG analyses suggesting potential pathways. Molecular docking was used to assess compound–target affinity. A lipopolysaccharide‐induced sarcopenia rat model was used to verify the targets. Sijunzi decoction contains 92 compounds and 47 targets for sarcopenia. The top 10 hub targets comprise AKT1, ALB, INS, IL6, TNF, TP53, VEGFA, SIRT1, CAT and FOS. GO and KEGG analyses indicate involvement in steroid hormone response, vesicle lumen, receptor agonist activity, and FoxO and HIF‐1 signaling pathways. Validation experiments showed that SJZD alleviates sarcopenia by downregulating SIRT1, IL‐6, TNF and AKT1. Sijunzi decoction treats sarcopenia by targeting SIRT1, IL‐6, TNF and AKT1, potentially involving FoxO and HIF‐1 signaling pathways. This highlights SJZD’s potential for sarcopenia treatment.

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Section: Discussionmentioning

confidence: 99%

Exploring the therapeutic mechanisms of Sijunzi decoction in the treatment of sarcopenia: Key targets and signaling pathways

Dai,

Wang,

Jiang

et al. 2023

Biomedical Chromatography

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show abstract

“… 18 A recent study has suggested that drugs targeting the TGF-β signaling pathway and its blockade have produced promising results in the management of diabetes and its associated complications. 19 These studies have highlighted the importance of TGF-β signaling in various diseases, including diabetes, but its specific role in DFU remains unclear. Therefore, this study fills a knowledge gap by exploring the relationship between TGF-β signaling pathway and DFU.…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics analysis identifies TGF-β signaling pathway-associated molecular subtypes and gene signature in diabetic foot

Du,

Chen,

Zhu

et al. 2024

iScience

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“…Diabetes mellitus (DM) is a heterogeneous metabolic complaint involving increased blood glucose (Talha et al, 2022), which is a result of inadequate insulin secretion, diminished insulin sensitivity, or both. DM is a polygenic condition with increased reactive oxygen species (ROS) and basal metabolic rate, along with deficiency in lipoproteins and free radical scavengers, and impairment of organs due to oxidative stress (Shah and Khan, 2014;Behl et al, 2022). Additionally, complications of DM include psychiatric complaints such as depression and anxiety, neurodegenerative impairments, and cognitive decline (Ceretta et al, 2012a;Reus et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Hyperglycemia-associated Alzheimer’s-like symptoms and other behavioral effects attenuated by Plumeria obtusa L. Extract in alloxan-induced diabetic rats

et al. 2022

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Diabetes mellitus is a chronic metabolic complaint with numerous short- and long-term complications that harm a person’s physical and psychological health. Plumeria obtusa L. is a traditional medicine used in the treatment of diabetes to reduce complications related to behavior. Plumeria is a genus with antipsychotic activities. The objective of this study was to examine the effects of a methanolic extract of Plumeria obtusa L. in the attenuation of diabetes, on symptoms of Alzheimer disease, and on other associated behavioral aspects. A single dose of alloxan was administered to an experimental group of rats to induce development of diabetes (150 mg/kg, intraperitoneal) and the rats were then administered selected doses of methanolic extract of Plumeria obtusa L. (Po.Cr) or glibenclamide (0.6 mg/kg) for 45 consecutive days. Behavioral effects were evaluated using three validated assays of anxiety-related behavior: the open field test, the light and dark test, and the elevated plus maze. Anti-depressant effects of Plumeria obtusa L. were evaluated using the forced swim test (FST) and memory and learning were assessed using the Morris water maze (MWM) task. Po.Cr was also evaluated for phytochemicals using total phenolic content (TPC), total flavonoid content (TFC), and high-performance liquid chromatography assays, and antioxidant capability was assessed through assays of DPPH radical scavenging, total oxidation capacity, and total reducing capacity. In the alloxan-induced model of diabetes, the administration of Po.Cr and glibenclamide for 45 days produced a marked decrease (p < 0.001) in hyperglycemia compared to control animals. Po.Cr treatment also resulted in improvement in indicators, such as body weight and lipid profile (p < 0.05), as well as restoration of normal levels of alanine transaminase (ALT) (p < 0.001), a biomarker of liver function. Diabetic rats presented more Alzheimer-like symptoms, with greater impairment of memory and learning, and increased anxiety and depression compared to non-diabetic normal rats, whereas treated diabetic rats showed significant improvements in memory and behavioral outcomes. These results demonstrate that Po.Cr reversed alloxan-induced hyperglycemia and ameliorated Alzheimer-related behavioral changes, which supports additional study and assessment of conventional use of the plant to treat diabetes and associated behavioral complications.

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Exploring the multifaceted role of TGF-β signaling in diabetic complications

Cited by 6 publications

References 78 publications

Exploring the therapeutic mechanisms of Sijunzi decoction in the treatment of sarcopenia: Key targets and signaling pathways

Exploring the therapeutic mechanisms of Sijunzi decoction in the treatment of sarcopenia: Key targets and signaling pathways

Bioinformatics analysis identifies TGF-β signaling pathway-associated molecular subtypes and gene signature in diabetic foot

Hyperglycemia-associated Alzheimer’s-like symptoms and other behavioral effects attenuated by Plumeria obtusa L. Extract in alloxan-induced diabetic rats

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