Exploring the performance of quadrupole, time-of-flight, and multi-collector ICP-MS for dual-isotope detection on single nanoparticles and cells

Results of an interlaboratory comparison for characterization of Pt nanoparticles using single-particle ICP-TOFMS

“…For reference, the performance of icpTOF instruments in terms of isotope ratio precision has been investigated for liquid samples, 23,57,58 μm-sized particles, 59 as well as Ag NPs and Ag-exposed cells. 56…”

“…20 A subsequent study compared the performance of three ICP-QMS, two ICP-TOFMS and one MC-ICP-MS for multi-element/isotope analysis in a particle/cell basis. 56 The determining factor for the acquired precision was the limited instrument sensitivity (or small particle size) and the relatively large difference in abundance of the isotopes involved. As previously discussed, ICP-MS instrumentation equipped with a QMS or ICP-SFMS, possess a single detector only and thus, does not allow for simultaneous multi-element analysis at the time scale of NP events.…”

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

“…Conventional scICP-MS has the capability to measure only one element concentration at a time in an individual cell, meaning that it is not possible to glean information about multiple elements or isotopes within the same cell. In order to explore multi-isotope/element determination with sc/spICP-MS , Tian et al 103 described a systematic comparison of the performance of three techniques, ICP-QMS, ICP-TOF-MS and MC-ICP-MS, to simultaneously detect two isotopes ( 107 Ag and 109 Ag) in both AgNPs using sp-mode and individual Ag-exposed cyanobacteria cells with sc-mode. The ICP-QMS platforms were used in “peak hopping” mode, which provides an approximation of simultaneous monitoring by alternatively scanning two m / z ratios at a very high frequency.…”

Atomic spectrometry update: review of advances in the analysis of metals, chemicals and materials

“…Tian et al compared the performance of three quadrupole, two TOF and one MC-ICP-MS instruments for measuring the 109 Ag : 107 Ag isotope ratio in silver NPs and Ag exposed cyanobacteria cells. 254 After optimisation, peak hopping mode, with sub ms dwell time and settling times was used for analysis using ICP-Q-MS. The TOF instrument monitored full mass spectra with a dwell time of 5 ms and for SP/single cell-MC-ICP-MS analysis, 30 000 cycles with a dwell time of 8 ms was used.…”