Exploring the photochemosensitivity by novel cysteine-based mixed ligand complexes

Selvaganapathy, Muthusamy; Pravin, Narayanaperumal; Muniyandi, Vellaichamy; Nazeer, Mohammed; Raman, Natarajan

doi:10.1016/j.jphotobiol.2016.02.008

Cited by 12 publications

(12 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…calc. (%) for C 22 1 H NMR (400 MHz, DMSO-d 6 ) δ/ppm: 3.272 (1H, dd, 3 J 1 = 9.6 Hz, 3 J 2 = 10.8 Hz, H-a), 4.122 (1H, dd, 3 J 1 = 11.6 Hz, 3 J 2 = 13.6 Hz, Hb), 5.791 (1H, dd, 3 J 1 = 10.4 Hz, 3 J 2 = 8.8 Hz, H 5 ), 6.761-8.081 (13H, m, H 3′,4′,5′,4″,5″,6″,7″,8″,2‴,3‴,4‴,5‴,6‴ ). 13…”

Section: Preparation Of 2-chloro-mentioning

confidence: 99%

“…After 24 h the numbers of dead nauplii were counted and from this the survival LC 50 was calculated. 21,22 Bioassay of Schizosaccharomyces pombe cells at cellular level A cellular level bioassay was carried out using Schizosaccharomyces pombe cells. The detailed process of measuring the cellular level cytotoxicity of the synthesized compounds is described in the literature.…”

Section: Biological Application Of the Compoundsmentioning

confidence: 99%

“…calc. (%) for C22 H 16 Cl 3 N 3 PtS: C, 40.29; H, 2.46; N, 6.41; Pt, 29.74; S, 4.89. Found (%): C, 40.45; H, 2.39; N, 6.37; Pt, 28.86; S, 4.37.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Synthesis, characterization and biological application of 5-quinoline 1,3,5-trisubstituted pyrazole based platinum(ii) complexes

et al. 2018

View full text Add to dashboard Cite

Square planar mononuclear platinum(ii) complexes were synthesized in the presence of neutral bidentate heterocyclic (5-quinoline 1,3,5-tri-substituted pyrazole scaffold) ligands and KPtCl salt. The synthesized compounds were characterized by micro-elemental analysis, FT-IR, UV-vis, H NMR,C NMR, TGA, mass spectrometry and molar conductivity. Their biological activities were investigated by brine shrimp lethality bioassay, antimicrobial study against five different pathogens, cellular level cytotoxicity against cells, and anti-proliferation assay. The binding constant, , values of the complexes were determined by DNA interaction studies. The gel electrophoresis assay was carried out to examine the effect of the complexes on the DNA nuclease of pUC19 plasmid DNA. The docking energies of the ligands ( ) and complexes () were observed in the range of -265.14 to -284.33 kJ mol. The synthesized Pt(ii) complexes () were screened against the MCF-7 (human breast adenocarcinoma) and HCT-116 (human colon carcinoma) cancer cell lines.

show abstract

Section: Preparation Of 2-chloro-mentioning

confidence: 99%

Section: Biological Application Of the Compoundsmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis, characterization and biological application of 5-quinoline 1,3,5-trisubstituted pyrazole based platinum(ii) complexes

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Among the various ligands, nitrogen-containing ligands and their metal complexes have been explored as viable compounds for therapeutic and pharmacological purposes . In particular, Schiff bases exhibit efficient bioactivity in a wide range of biological applications .…”

Section: Introductionmentioning

confidence: 99%

Thiophene-Derived Schiff Base Complexes: Synthesis, Characterization, Antimicrobial Properties, and Molecular Docking

et al. 2023

View full text Add to dashboard Cite

Novel thiophene-derived Schiff base ligand DE, where DE is (E)-N 1 ,N 1 -diethyl-N 2 -(thiophen-2-ylmethylene)ethane-1,2-diamine, and the corresponding M(II) complexes, [M(DE)X 2 ] (M = Cu or Zn, X = Cl; M = Cd, X = Br), were prepared and structurally characterized. X-ray diffraction studies revealed that the geometry around the center of the M(II) complexes, [Zn(DE)Cl 2 ] and [Cd(DE)Br 2 ], could be best described as a distorted tetrahedral. In vitro antimicrobial screening of DE and its corresponding M(II) complexes, [M(DE)X 2 ], was performed. The complexes were more potent and showed higher activities against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, fungi Candida albicans, and protozoa Leishmania major compared to the ligand. Among the studied complexes, [Cd(DE)Br 2 ] exhibited the most promising antimicrobial activity against all the tested microbes compared to its analogs. These results were further supported by molecular docking studies. We believe that these complexes may significantly contribute to the efficient designing of metal-derived agents to treat microbial infections.

show abstract

“…Among the several ligands, metal complexes with nitrogen-containing ligands have been investigated as potential drugs for medical and pharmacological uses. 13 Schiff base ligands have drawn more attention due to the remarkable structural and synthetic characteristics, fine tunability, and chemical selectivity of the central metal atom. 14,15 The presence of the azomethine group (>C=N) in Schiff bases plays a pivotal role in controlling the behavior of central ions in a wide range of intriguing pharmaceutical and biological research.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic elucidation, density functional theory calculation, and molecular docking studies of a novel series of tetradentate macrocyclic Schiff base ligands and their Zn(II) complexes and investigations of their antimicrobial, anti‐inflammatory, and anticancer activities

Mamta,

Pinki,

Chaudhary

2023

Applied Organom Chemis

View full text Add to dashboard Cite

In the present work, novel Schiff base macrocyclic Zn(II) complexes [Zn(N8O4MacL1)Cl2–Zn(N8O4MacL3)Cl2] were synthesized by the reaction of ZnCl2 and macrocyclic ligands (N8O4MacL1–N8O4MacL3) derived from the condensation of ligand (L) and dicarboxylic acids [HOOC‐(CH2)n‐COOH]. The structural confirmation of the newly synthesized compounds was accomplished through various analytical techniques, including elemental analysis, infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), UV–visible spectroscopy, and powder X‐ray diffraction (XRD) studies. The spectral data provided evidence that the macrocyclic ligands acted as tetradentate ligands, forming coordination bonds with Zn(II) ions through the nitrogen atom of the imine (>C=N) group. The coordination complexes exhibited an octahedral geometry around the zinc ion, with two chloro groups covalently attached. Density functional theory (DFT) studies of the synthesized Schiff base macrocyclic compounds were carried out to determine their structural and electronic properties. The antimicrobial potential of the macrocyclic compounds was examined against a panel of pathogenic microbes, including four bacterial strains (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Xanthomonas campestris) and two fungal strains (Fusarium oxysporum and Candida albicans). Then, the newly synthesized Schiff based macrocyclic compounds were evaluated for their anti‐inflammatory activity using an egg albumin method. The synthesized compounds were subjected to further evaluation to assess their potential as anticancer agents against MCF‐7 (human breast adenocarcinoma cell line), HCT‐116 (human colon cancer cell line), and A549 (human alveolar adenocarcinoma epithelial cell line). In addition, molecular docking studies were conducted to explore the potential interactions between the synthesized compounds and the target proteins VEGFR2 (PDB ID 1YWN), EGFR (PDB ID 1M17), and DNA gyrase B (PDB ID 4URO). It was found that there was a high correlation between the experimental results and the docking calculations.

show abstract

Exploring the photochemosensitivity by novel cysteine-based mixed ligand complexes

Cited by 12 publications

References 46 publications

Synthesis, characterization and biological application of 5-quinoline 1,3,5-trisubstituted pyrazole based platinum(ii) complexes

Synthesis, characterization and biological application of 5-quinoline 1,3,5-trisubstituted pyrazole based platinum(ii) complexes

Thiophene-Derived Schiff Base Complexes: Synthesis, Characterization, Antimicrobial Properties, and Molecular Docking

Synthesis, spectroscopic elucidation, density functional theory calculation, and molecular docking studies of a novel series of tetradentate macrocyclic Schiff base ligands and their Zn(II) complexes and investigations of their antimicrobial, anti‐inflammatory, and anticancer activities

Contact Info

Product

Resources

About