Exploring the plant-derived bioactive substances as antidiabetic agent: An extensive review

Rahman, Md. Mominur; Dhar, Puja Sutro; Sumaia,; Anika, Fazilatunnesa; Ahmed, Limon; Islam, Md. Rezaul; Sultana, Nazneen; Cavalu, Simona; Pop, Ovidiu; Rauf, Abdur

doi:10.1016/j.biopha.2022.113217

Cited by 96 publications

(55 citation statements)

References 186 publications

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“…Therapy with oral glucocorticoids usually results in a positive outcome. Plasmapheresis and intravenous immunoglobulin (IVIG) are also successful treatments [194,223,[230][231][232][233][234][235][236]. 9.4.…”

Section: 3mentioning

confidence: 99%

Emerging Role of Neuron-Glia in Neurological Disorders: At a Glance

Rahman

Islam

Yamin

et al. 2022

Oxidative Medicine and Cellular Longevity

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Based on the diverse physiological influence, the impact of glial cells has become much more evident on neurological illnesses, resulting in the origins of many diseases appearing to be more convoluted than previously happened. Since neurological disorders are often random and unknown, hence the construction of animal models is difficult to build, representing a small fraction of people with a gene mutation. As a result, an immediate necessity is grown to work within in vitro techniques for examining these illnesses. As the scientific community recognizes cell-autonomous contributions to a variety of central nervous system illnesses, therapeutic techniques involving stem cells for treating neurological diseases are gaining traction. The use of stem cells derived from a variety of sources is increasingly being used to replace both neuronal and glial tissue. The brain’s energy demands necessitate the reliance of neurons on glial cells in order for it to function properly. Furthermore, glial cells have diverse functions in terms of regulating their own metabolic activities, as well as collaborating with neurons via secreted signaling or guidance molecules, forming a complex network of neuron-glial connections in health and sickness. Emerging data reveals that metabolic changes in glial cells can cause morphological and functional changes in conjunction with neuronal dysfunction under disease situations, highlighting the importance of neuron-glia interactions in the pathophysiology of neurological illnesses. In this context, it is required to improve our understanding of disease mechanisms and create potential novel therapeutics. According to research, synaptic malfunction is one of the features of various mental diseases, and glial cells are acting as key ingredients not only in synapse formation, growth, and plasticity but also in neuroinflammation and synaptic homeostasis which creates critical physiological capacity in the focused sensory system. The goal of this review article is to elaborate state-of-the-art information on a few glial cell types situated in the central nervous system (CNS) and highlight their role in the onset and progression of neurological disorders.

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Section: 3mentioning

confidence: 99%

Emerging Role of Neuron-Glia in Neurological Disorders: At a Glance

Rahman

Islam

Yamin

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…However, it is worth mentioning that many challenging disorders are associated with a variety of objective proteins [ 32 , 33 , 34 ]. Furthermore, due to certain medicines having “poly-pharmacological” characteristics, unanticipated drug functionalities resulting from off-targets that are uncontrolled and unavoidable can lead to unpleasant side effects [ 7 , 35 , 36 , 37 , 38 , 39 ]. Sildenafil (Viagra), for example, is currently used to treat erectile dysfunction in men but was primarily designed for the treatment of angina [ 40 ].…”

Section: Anticancer Drug Target Predictionmentioning

confidence: 99%

Emerging Promise of Computational Techniques in Anti-Cancer Research: At a Glance

et al. 2022

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Research on the immune system and cancer has led to the development of new medicines that enable the former to attack cancer cells. Drugs that specifically target and destroy cancer cells are on the horizon; there are also drugs that use specific signals to stop cancer cells multiplying. Machine learning algorithms can significantly support and increase the rate of research on complicated diseases to help find new remedies. One area of medical study that could greatly benefit from machine learning algorithms is the exploration of cancer genomes and the discovery of the best treatment protocols for different subtypes of the disease. However, developing a new drug is time-consuming, complicated, dangerous, and costly. Traditional drug production can take up to 15 years, costing over USD 1 billion. Therefore, computer-aided drug design (CADD) has emerged as a powerful and promising technology to develop quicker, cheaper, and more efficient designs. Many new technologies and methods have been introduced to enhance drug development productivity and analytical methodologies, and they have become a crucial part of many drug discovery programs; many scanning programs, for example, use ligand screening and structural virtual screening techniques from hit detection to optimization. In this review, we examined various types of computational methods focusing on anticancer drugs. Machine-based learning in basic and translational cancer research that could reach new levels of personalized medicine marked by speedy and advanced data analysis is still beyond reach. Ending cancer as we know it means ensuring that every patient has access to safe and effective therapies. Recent developments in computational drug discovery technologies have had a large and remarkable impact on the design of anticancer drugs and have also yielded useful insights into the field of cancer therapy. With an emphasis on anticancer medications, we covered the various components of computer-aided drug development in this paper. Transcriptomics, toxicogenomics, functional genomics, and biological networks are only a few examples of the bioinformatics techniques used to forecast anticancer medications and treatment combinations based on multi-omics data. We believe that a general review of the databases that are now available and the computational techniques used today will be beneficial for the creation of new cancer treatment approaches.

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“…Antidiabetic Activity. Different plant extracts treat diabetes mellitus [166][167][168]. Centella asiatica, Hedychium coronarium, Ipomea aquatic, Pistia stratiotes, Spergularia marina, and Nymphaea nouchali have been reported as medicinal plants with effective antidiabetic properties due to their potency in the wide range of bioactive compounds [41,169].…”

Section: Antiparasitic Activitymentioning

confidence: 99%

Ethnomedicinal Use, Phytochemistry, and Other Potential Application of Aquatic and Semiaquatic Medicinal Plants

Arya

Durgapal

Bachheti

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Medicinal plants have been treating various ailments and diseases since ancient times. Aquatic and semiaquatic medicinal plants play an essential role in human welfare to fulfill their daily needs. They have shown biological, pharmacological, nutraceutical, and commercial applications. This review aims to collect and update all recent information on ethnomedicinal, phytochemistry, pharmacological activities, and nanoparticle synthesis and their uses in aquatic and semiaquatic medicinal plants. Original research papers, review papers, short communications, and book chapters on aquatic and semiaquatic plants have been retrieved from PubMed, Web of Science, Scopus, and Google Scholar. Keywords, ethnomedicinal studies, phytochemistry, pharmacological activities, and nanoparticle synthesis from aquatic and semiaquatic medicinal plants are used for the search. Different aquatic and semiaquatic medicinal plants belonging to the families Acanthaceae, Alismataceae, Amaranthaceae, Apiaceae, Araceae, Asteraceae, Boraginaceae, Ceratophyllaceae, Cyperaceae, Fabaceae, Hydrocharitaceae, Lythraceae, Marsileaceae, Menyanthaceae, Nelumbonaceae, Nymphaeaceae, Onagraceae, Plantaginaceae, Poaceae, Polygonaceae, Pontederiaceae, Primulaceae, Scrophulariaceae, and Zingiberaceae have been studied. They are rich in alkaloids, flavonoids, terpenoids, phenolics, saponins, tannins, dietary fiber, glycosidic derivatives, carbohydrates, and proteins. These phytochemicals have been used for their antimicrobial, antioxidant, hepatoprotective, sedative, anticonvulsant, cytotoxic, antiparasitic, and antidiabetic activities. Besides this, various parts of the plants are used as dietary supplements and green nanoparticle synthesis. These plants are also known for their commercial value and are used as an ingredient in some pharmaceutical industries.

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Exploring the plant-derived bioactive substances as antidiabetic agent: An extensive review

Cited by 96 publications

References 186 publications

Emerging Role of Neuron-Glia in Neurological Disorders: At a Glance

Emerging Role of Neuron-Glia in Neurological Disorders: At a Glance

Emerging Promise of Computational Techniques in Anti-Cancer Research: At a Glance

Ethnomedicinal Use, Phytochemistry, and Other Potential Application of Aquatic and Semiaquatic Medicinal Plants

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