2022
DOI: 10.7717/peerj.12768
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Exploring the potential biomarkers for prognosis of glioblastoma via weighted gene co-expression network analysis

Abstract: Background Glioblastoma (GBM) is the most common malignant tumor in the central system with a poor prognosis. Due to the complexity of its molecular mechanism, the recurrence rate and mortality rate of GBM patients are still high. Therefore, there is an urgent need to screen GBM biomarkers to prove the therapeutic effect and improve the prognosis. Results We extracted data from GBM patients from the Gene Expression Integration Database (GEO… Show more

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Cited by 4 publications
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“…STYXL1 overexpression can promote glioma cell growth and migration [ 40 ]. CDC73 is a member of the cyclins family, which can prevent cell from growing and dividing too fast or out of control, and involves in tumorigenesis of GBM [ 41 ].…”
Section: Discussionmentioning
confidence: 99%
“…STYXL1 overexpression can promote glioma cell growth and migration [ 40 ]. CDC73 is a member of the cyclins family, which can prevent cell from growing and dividing too fast or out of control, and involves in tumorigenesis of GBM [ 41 ].…”
Section: Discussionmentioning
confidence: 99%
“…For example, Aspartyl-tRNA Synthetase (DARS), which is responsible for the attachment of aspartate to the appropriate transfer RNA (tRNA) molecule and ensures its proper incorporation into the growing polypeptide chain, has been positively correlated with tumor purity. Findings based on gene co-expression analysis in GBM suggest that DARS is significantly upregulated upon cisplatin treatment, which has been shown to decrease cisplatin sensitivity [ 42 , 82 ]. However, this expression was downregulated in the combination-treated group.…”
Section: Discussionmentioning
confidence: 99%