Exploring the potential for an evolutionarily conserved role of the taste 1 receptor gene family in gut sensing mechanisms of fish

Angotzi, Anna Rita; Leal, Esther; Puchol, Sara; Cerdá‐Reverter, José Miguel; Morais, Sofía

doi:10.1016/j.aninu.2022.08.010

Cited by 3 publications

(1 citation statement)

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“…The amino acid sensory receptors were mainly reported in mammals that could sense the presence of amino acids in the intestinal lumen and convey the expected signal that nutrients are about to be imminently digested and systemic increase, which is conducive to mobilizing the amino acid metabolism [63,64]. And similar amino acid sensing mechanism was reported in fish intestines [62,65]. It suggested that dietary blended proteins enhanced the intestine's sense of amino acids.…”

Section: Discussionmentioning

confidence: 80%

Effects of the Replacement of Dietary Fishmeal by the Blend of Tenebrio molitor Meal, Chlorella Meal, Clostridium Autoethanogenum Protein, and Cottonseed Protein Concentrate on Growth, Protein Utilization, and Intestinal Health of Gibel Carp (Carassius gibelio, CAS Ⅴ)

Yu,

Wang,

Jin

et al. 2024

Aquaculture Nutrition

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The trial was conducted to investigate the effects of the replacement of dietary fishmeal (FM) by the blend of Tenebrio molitor meal (TMM), Chlorella meal (CM), Clostridium autoethanogenum protein (CAP), cottonseed protein concentrate (CPC) on growth, protein utilization and intestinal health of gibel carp (Carassius gibelio, CAS Ⅴ). The FM-based diet was used as the control, and the blended proteins (TMM: CM: CAP: CPC) at ratios of 1 : 1:8 : 2 (BLEND A), 1 : 1:6 : 4 (BLEND B), and 1 : 1:4 : 6 (BLEND C) were used to replace FM at three levels (33%, 67%, 100%), respectively. The results showed that, compared to the control group, growth performance increased significantly when dietary FM was fully replaced by BLEND B (P<0.05), while decreased by BLEND A (P<0.05). The complete substitution of FM with BLEND B significantly upregulated the mRNA expression of intestinal proinflammatory cytokines, anti-inflammatory cytokines, and tight junction-related genes (P<0.05), improving intestinal tissue morphology and health. And it also significantly increased intestinal trypsin activity (P<0.05), upregulated the mRNA expression of amino acid sensory receptor-related and amino acid or peptide transport-related genes (P<0.05), increased protein apparent digestibility coefficient (P<0.05). The 100% substitution of FM with BLEND A significantly upregulated the mRNA expression of intestinal proinflammatory cytokines and downregulated the mRNA expression of anti-inflammatory cytokine il-10 (P <0.05), reduced intestinal villus height (P<0.05), and decreased protein apparent digestibility coefficient (P<0.05). In conclusion, BLEND B could completely substitute dietary FM and was beneficial to the growth and health of gibel carp. Dietary digestible essential amino acids index (DEEAI) was found as an important indicator and should be higher than 79.5% to meet the maximum growth of fish.

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