Exploring the potential of pH-sensitive polymers in targeted drug delivery

Gomte, Shyam Sudhakar; Agnihotri, Tejas Girish; Khopade, Shivani; Jain, Aakanchha

doi:10.1080/09205063.2023.2279792

Cited by 14 publications

(4 citation statements)

References 193 publications

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“…Many biopolymers such as chitosan, cellulose and collagen, etc., have unique properties that can hold, resist, and protect the drug during the acidic pH of the stomach, then release it when the pH is neutralized. [70] In one study by Feng and co-workers, they used alginate/chitosan as biopolymeric shells and mesoporous silica as an inorganic core to create a hybrid aerogel delivery system Reproduced with permission. [73] 2018 American Chemical Society.…”

Section: Ph-responsive Biopolymeric Aerogelsmentioning

confidence: 99%

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Alkhalidi,

Alahmadi,

Rizg

et al. 2024

Macromol. Rapid Commun.

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Cancer stands as a leading cause of global mortality, with chemotherapy being a pivotal treatment approach, either alone or in conjunction with other therapies. The primary goal these therapies is to inhibit the growth of cancer cells specifically, while minimizing harm to healthy dividing cells. Conventional treatments have been hampered by their side effects, often causing severe discomfort to patients. Researchers have been exploring innovative approaches to target cancer cells selectively. In this context, biopolymer‐based aerogels emerge as innovative platforms, showcasing unique properties that respond intelligently to diverse stimuli, including temperature, pH variations, magnetic fields, and redox potential. This responsiveness enables precise control over the release of anticancer drugs, enhancing therapeutic outcomes. The significance of these aerogels lies in their ability to offer targeted drug delivery with increased efficacy, biocompatibility, and a high drug payload. In this comprehensive review, we discuss the role of biopolymer‐based aerogels as an emerging functionalized platforms in anticancer drug delivery. The review addresses the unique properties of biopolymer‐based aerogels showing their smart behavior in responding to different stimuli including temperature, pH, magnetic and redox potential to control anticancer drug release. Finally, the review discusses the application of different biopolymer‐based aerogel in delivering different anticancer drugs and also discusses the potential of these platforms in gene delivery applications. This article is protected by copyright. All rights reserved

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Section: Ph-responsive Biopolymeric Aerogelsmentioning

confidence: 99%

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Alkhalidi,

Alahmadi,

Rizg

et al. 2024

Macromol. Rapid Commun.

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“…Another important advancement came in 2010, with the incorporation of environment responsive/smart polymers into dressings. These polymers respond to changes in temperature, pH, light, enzymes, and reactive oxygen species (ROS) within the wound environment. , This innovation allows for the precise release of encapsulated drugs in response to the changing conditions of the wound, thereby easing the healing process, improving patient compliance, and reducing both the cost and duration of therapy . The modern advanced wound dressings are composed of drug loaded film, hydrocolloid, hydrofiber, hydrogel, ,, and foam formulations.…”

Section: Introductionmentioning

confidence: 99%

Advanced Dressings for Chronic Wound Management

Mishra,

Kushare,

Gupta

et al. 2024

ACS Appl. Bio Mater.

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Wound healing, particularly for chronic wounds, presents a considerable difficulty due to differences in biochemical and cellular processes that occur in different types of wounds. Recent technological breakthroughs have notably advanced the understanding of diagnostic and therapeutic approaches to wound healing. The evolution in wound care has seen a transition from traditional textile dressings to a variety of advanced alternatives, including self-healing hydrogels, hydrofibers, foams, hydrocolloids, environment responsive dressings, growth factor-based therapy, bioengineered skin substitutes, and stem cell and gene therapy. Technological advancements, such as 3D printing and electronic skin (e-skin) therapy, contribute to the customization of wound healing. Despite these advancements, effectively managing chronic wounds remains challenging. This necessitates the development of treatments that consider performance, risk–benefit balance, and cost-effectiveness. This review discusses innovative strategies for the healing of chronic wounds. Incorporating biomarkers into advanced dressings, coupled with corresponding biosensors and drug delivery formulations, enables the theranostic approach to the treatment of chronic wounds. Furthermore, integrating advanced dressings with power sources and user interfaces like near-field communication, radio frequency identification, and Bluetooth enhances real-time monitoring and on-demand drug delivery. It also provides a thorough evaluation of the advantages, patient compliance, costs, and durability of advanced dressings, emphasizing smart formulations and their preparation methods.

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“…Some non-electrically driven actuators are stimulus-responsive actuators. They are sensitive to external environmental influences such as light [31], water [32], electric field [33], pH [34][35][36], and temperature [37,38]. However, because these actuators operate in response to environmental stimuli, there are limitations on the conditions under which they can be used.…”

Section: Introductionmentioning

confidence: 99%

Non-Electrically Driven Acoustic Actuator

Niwano,

Matsumoto

2024

Actuators

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Nuclear power plants have high radiation levels and humans cannot work directly on them. Therefore, it is necessary to establish effective repair work methods. One promising approach is the use of disaster relief robots. However, strong radiation affects circuits and electronic devices. Because typical robots contain electrical circuits and are controlled by radio waves, they are difficult to use in highly radioactive environments. In this study, we propose a non-electrically driven acoustic actuator that does not use electronic circuits and is driven by sound waves. To realize this goal, we have investigated a sound wave drive using a cylindrical container.

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Exploring the potential of pH-sensitive polymers in targeted drug delivery

Cited by 14 publications

References 193 publications

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Advanced Dressings for Chronic Wound Management

Non-Electrically Driven Acoustic Actuator

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