Exploring the quality markers and mechanism of Bushen Huoxue Prescription in prevention and treatment of diabetic retinopathy based on Chinmedomics strategy

Wang, Jia; Wei, Fangyong; Wang, Yu; Liu, Qingze; He, Run-Xi; Huang, Yuxia; Xie, Xuejun; Zhang, Mei

doi:10.1016/j.jep.2022.116131

Cited by 12 publications

(4 citation statements)

References 30 publications

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“…Instrument: Waters ACQUITY UPLC H Class-Waters Synapt G2 Si QTOF. Analysis method of the chromatographic profile: Stationary phase: Waters Acquity HSS T3, (100 × 2.1 mm, 1.8 μm); mobile phase: aqueous with 0.1% formic acid (I) and acetonitrile with 0.1% formic acid (II) (0–15 min, 2–30% II; 15–20 min, 30–50% II; 20–25 min, 50–95% II; 25–29 min, 95% II; 27–30 min, 2% II) [ 11 , 12 ].…”

Section: Methodsmentioning

confidence: 99%

Role of Bushen Huoxue Formula and transplanted endothelial progenitor cells play in promoting endplate microcirculation and attenuating intervertebral disc degeneration

Xie,

Zhang,

Yang

et al. 2024

Heliyon

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Section: Methodsmentioning

confidence: 99%

Role of Bushen Huoxue Formula and transplanted endothelial progenitor cells play in promoting endplate microcirculation and attenuating intervertebral disc degeneration

Xie,

Zhang,

Yang

et al. 2024

Heliyon

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“…Given the multi-target, multi-component treatment approach of traditional Chinese medicine and the holistic focus of metabolomics, Chinmedomics represents a harmonious integration of both domains. By discovering biomarkers unique to specific Traditional Chinese Medicine syndromes, it offers a modern scientific interpretation of ancient TCM theories [121,[124][125][126].…”

Section: Chinmedomicsmentioning

confidence: 99%

Review on analytical technologies and applications in metabolomics

MENG,

LIU,

et al. 2024

BIOCELL

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Over the past decade, the swift advancement of metabolomics can be credited to significant progress in technologies such as mass spectrometry, nuclear magnetic resonance, and multivariate statistics. Currently, metabolomics garners widespread application across diverse fields including drug research and development, early disease detection, toxicology, food and nutrition science, biology, prescription, and chinmedomics, among others.Metabolomics serves as an effective characterization technique, offering insights into physiological process alterations in vivo. These changes may result from various exogenous factors like environmental conditions, stress, medications, as well as endogenous elements including genetic and protein-based influences. The potential scientific outcomes gleaned from these insights have catalyzed the formulation of innovative methods, poised to further broaden the scope of this domain. Today, metabolomics has evolved into a valuable and widely accepted instrument in the life sciences. However, comprehensive reviews focusing on the sample preparation and analytical methodologies employed in metabolomics within the life sciences are surprisingly scant. This review aims to fill that gap, providing an overview of current trends and recent advancements in metabolomics. Particular emphasis is placed on sample preparation, sophisticated analytical techniques, and their applications in life science research.

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“…as potential Q-markers for Chaiqin chengqi decoction (CQCQD) based on UPLC-QQQ-MS. Chu et al (2022) found sweroside, paeoniflorin, liquiritigenin, chlorogenic acid, calycosin-7-glucoside, formononetin and 3-butylephthalide to be Q-markers of the Mailuoshutong pill based on TCM theory and metabolomics techniques. Wang et al (2023) used UPLC-Q-Exactive Orbitrap MS to identify five active ingredients in Bushen Huoxue Prescription as potential Q markers against diabetic retinopathy, tanshinone IIA, puerarin, ajugol, protocatechuic acid and panaxatriol. used UHPLC-LTQ-Orbitrap MS to analyze and identify the active components in Panax notoginseng and found a new efficacy grading marker alkynol related to Panax notoginseng, which can be used as a new grading quality marker.…”

Section: Quality Markers and Quality Controlmentioning

confidence: 99%

Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine

et al. 2023

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Natural products derived from herbal medicine are a fruitful source of lead compounds because of their structural diversity and potent bioactivities. However, despite the success of active compounds derived from herbal medicine in drug discovery, some approaches cannot effectively elucidate the overall effect and action mechanism due to their multi-component complexity. Fortunately, mass spectrometry-based metabolomics has been recognized as an effective strategy for revealing the effect and discovering active components, detailed molecular mechanisms, and multiple targets of natural products. Rapid identification of lead compounds and isolation of active components from natural products would facilitate new drug development. In this context, mass spectrometry-based metabolomics has established an integrated pharmacology framework for the discovery of bioactivity-correlated constituents, target identification, and the action mechanism of herbal medicine and natural products. High-throughput functional metabolomics techniques could be used to identify natural product structure, biological activity, efficacy mechanisms, and their mode of action on biological processes, assisting bioactive lead discovery, quality control, and accelerating discovery of novel drugs. These techniques are increasingly being developed in the era of big data and use scientific language to clarify the detailed action mechanism of herbal medicine. In this paper, the analytical characteristics and application fields of several commonly used mass spectrometers are introduced, and the application of mass spectrometry in the metabolomics of traditional Chinese medicines in recent years and its active components as well as mechanism of action are also discussed.

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Exploring the quality markers and mechanism of Bushen Huoxue Prescription in prevention and treatment of diabetic retinopathy based on Chinmedomics strategy

Cited by 12 publications

References 30 publications

Role of Bushen Huoxue Formula and transplanted endothelial progenitor cells play in promoting endplate microcirculation and attenuating intervertebral disc degeneration

Role of Bushen Huoxue Formula and transplanted endothelial progenitor cells play in promoting endplate microcirculation and attenuating intervertebral disc degeneration

Review on analytical technologies and applications in metabolomics

Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine

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