Exploring the relationship between novel Coronavirus pneumonia and Parkinson’s disease

Xi, Xiaoming; Liang, Han

doi:10.1097/md.0000000000031813

Cited by 2 publications

(9 citation statements)

References 92 publications

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“…Parkinson’s disease (PD) ranks second among all neurodegenerative disorders in terms of its morbidity, and its prevalence is rising ( 1 , 2 ). It has been reported that PD affects more than 6 million people worldwide, and that number may rise to 10 million by 2030 ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

Dietary supplementation of Acanthopanax senticosus extract alleviates motor deficits in MPTP-induced Parkinson’s disease mice and its underlying mechanism

Jia

et al. 2023

Front. Nutr.

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Acanthopanax senticosus extract (ASE), a dietary supplement with antifatigue, neuroprotective, and immunomodulatory properties, has been widely used due to its high polyphenol content. Our previous study showed that ASE could be used to treat Parkinson’s disease (PD) as it contains multiple monoamine oxidase B inhibitors prescribed in early PD. However, its mechanism remains ambiguous. In this study, we investigated the protective effects of ASE on MPTP-induced PD in mice and explored the underlying mechanisms of action. We found that the administration of ASE significantly improved motor coordination in mice with MPTP-induced PD. As shown by quantitative proteomic analysis, 128 proteins’ expression significantly changed in response to ASE administration, most of which were involved with Fcγ receptor-mediated phagocytosis in macrophages and monocytes signaling pathway, PI3K/AKT signaling pathway, and insulin receptor signaling pathway. Furthermore, the network analysis results showed that ASE modulates protein networks involved in regulating cellular assembly, lipid metabolism, and morphogenesis, all of which have implications for treating PD. Overall, ASE served as a potential therapeutic because it regulated multiple targets to improve motor deficits, which could lay the strong foundation for developing anti-PD dietary supplements.

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Section: Introductionmentioning

confidence: 99%

Dietary supplementation of Acanthopanax senticosus extract alleviates motor deficits in MPTP-induced Parkinson’s disease mice and its underlying mechanism

Jia

et al. 2023

Front. Nutr.

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“…25 Myopia, however, has been little researched in this context, despite the known retinal structural consequences, 26 as well as the known importance of retinal image quality and function on normal ocular development. 27,28 Nonetheless, speculation may be growing in this area; recently, a review paper was published examining the Chinese and Western medicinal perspectives on the relationship between the gut microbiota and the pathological mechanisms of myopia in adolescents, 29 and one paper has characterised the ocular microbiome between low and high myopia, finding a higher relative abundance of Proteobacteria at the phylum level and Acinetobacter at the genus level in patients with high myopia. 30 In addition, studies on the gut microbiome of myopic individuals are limited.…”

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confidence: 99%

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confidence: 99%

“…A review by Xi et al 29 proposes a possible mechanism linking myopia to the gut microbiome that involves changes in dopamine production. Certain gut bacteria, such as enterococci, may possess homologues of enzyme genes similar to those found in mammals for the production of dopamine 29,32,33 via the existing phenylalanine-tyrosinedopa-dopamine pathway. 29,34 Several case reports have reported that oral antibiotics have caused a transient effect of myopia, [35][36][37] and once the medication was stopped or changed to other medications, the effect had reversed.…”

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confidence: 99%

“…Certain gut bacteria, such as enterococci, may possess homologues of enzyme genes similar to those found in mammals for the production of dopamine 29,32,33 via the existing phenylalanine-tyrosinedopa-dopamine pathway. 29,34 Several case reports have reported that oral antibiotics have caused a transient effect of myopia, [35][36][37] and once the medication was stopped or changed to other medications, the effect had reversed. It could be speculated that antibiotics might have an effect on the dopamine-producing bacteria, because dopamine can be synthesised in the gut by these bacteria and released into the bloodstream and travels to the brain and other parts of the body to perform its functions.…”

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confidence: 99%

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Gut Microbiota Profiles in Myopes and Nonmyopes

Omar,

Singh,

McBain

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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Purpose To identify compositional differences in the gut microbiome of nonmyopes (NM) and myopes using 16S ribosomal RNA sequencing and to investigate whether the microbiome may contribute to the onset or progression of the condition. Methods Faecal samples were collected from 52 adult participants, of whom 23 were NM, 8 were progressive myopes (PM), and 21 were stable myopes (SM). The composition of the gut microbiota in each group was analysed using 16S ribosomal RNA gene sequencing. Results There were no significant differences in alpha and beta diversity between the three groups (NM, PM, and SM). However, the distributions of Bifidobacterium , Bacteroides , Megamonas , Faecalibacterium , Coprococcus , Dorea , Roseburia , and Blautia were significantly higher in the myopes (SM and PM combined) when compared with emmetropes. The myopes exhibited significantly greater abundance of bacteria that are linked to the regulation of dopaminergic signalling, such as Clostridium , Ruminococcus , Bifidobacterium , and Bacteroides . Individuals with stable myopia were found to have a significantly higher proportion of Prevotella copri than those with progressive myopia. Bifidobacterium adolescentis , a gamma-aminobutyric acid (GABA)–producing bacterium, was significantly higher in all myopes than in NM and, in the comparison between SM and PM, it is significantly higher in SM. B. uniformis and B. fragilis , both GABA-producing Bacteroides , were present in relatively high abundance in all myopes and in SM compared with PM, respectively. Conclusions The presence of bacteria related to dopamine effect and GABA-producing bacteria in the gut microbiome of myopes may suggest a role of these microorganisms in the onset and progression of myopia.

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Exploring the relationship between novel Coronavirus pneumonia and Parkinson’s disease

Cited by 2 publications

References 92 publications

Dietary supplementation of Acanthopanax senticosus extract alleviates motor deficits in MPTP-induced Parkinson’s disease mice and its underlying mechanism

Dietary supplementation of Acanthopanax senticosus extract alleviates motor deficits in MPTP-induced Parkinson’s disease mice and its underlying mechanism

Gut Microbiota Profiles in Myopes and Nonmyopes

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