Exposome-wide Association Study for Metabolic Syndrome

Gao, Peng; Snyder, M

doi:10.3389/fgene.2021.783930

Cited by 7 publications

(9 citation statements)

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“…Extensive studies have been conducted on the genome and microbiome; however, the human exposome is rarely investigated, especially at the individual level. Exposomics research aims to characterize all physical, chemical, and biological components collectively in the human external and internal environment and investigate the internal molecular, physiological, and health-related effects of these exposures ( Gao and Snyder 2021 ). The external environment consists of all potential exposures from the near-field to the far-field sources of exogenous chemical, biological, and physical exposures ( Li et al 2012 , 2014 ; Liu et al 2019 ; Guo et al 2020b ).…”

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confidence: 99%

Precision environmental health monitoring by longitudinal exposome and multi-omics profiling

et al. 2022

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Conventional environmental health studies have primarily focused on limited environmental stressors at the population level, which lacks the power to dissect the complexity and heterogeneity of individualized environmental exposures. Here, as a pilot case study, we integrated deep-profiled longitudinal personal exposome and internal multi-omics to systematically investigate how the exposome shapes a single individual's phenome. We annotated thousands of chemical and biological components in the personal exposome cloud and found they were significantly correlated with thousands of internal biomolecules, which was further cross-validated using corresponding clinical data. Our results showed that agrochemicals and fungi predominated in the highly diverse and dynamic personal exposome, and the biomolecules and pathways related to the individual's immune system, kidney, and liver were highly associated with the personal external exposome. Overall, this data-driven longitudinal monitoring study shows the potential dynamic interactions between the personal exposome and internal multi-omics, as well as the impact of the exposome on precision health by producing abundant testable hypotheses.

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Precision environmental health monitoring by longitudinal exposome and multi-omics profiling

et al. 2022

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“…This integrated approach can elucidate connections between the exposome and the cellular phenotype, enabling a deeper understanding of the impact of environmental exposures on cellular function and disease pathogenesis. 6 In conclusion, spatial single-cell exposomics not only is an innovative analytical approach but also leads to a new dimension of understanding the cellular exposome. With continued refinement and advancements, this holds tremendous potential for reshaping our understanding of cellular function and disease processes, offering a new lens through which we can explore the intricate tapestry of cellular interactions with the microenvironment.…”

Section: Spatial Single-cell Exposomicsmentioning

confidence: 99%

“…This integrated approach could lead to the identification of novel molecular pathways involved in disease onset and progression caused by xenobiotic exposures. 6 In summary, single-cell-type exposomics represents a potent tool for dissecting cell-specific responses to environmental exposures. Despite the technical obstacles, advancements in single-cell isolation technologies and high-resolution analytical tools are projected to further extend the frontiers of this field, illuminating cell-specific disease mechanisms and potential prevention strategies in ways previously unimagined.…”

Section: Single-cell-type Exposomicsmentioning

confidence: 99%

“…Moreover, spatial single-cell exposomics can be coupled with other single-cell technologies such as single-cell RNA sequencing (scRNA-seq) or single-cell ATAC sequencing, allowing for simultaneous examination of the transcriptome or accessible chromatin within the same cell. This integrated approach can elucidate connections between the exposome and the cellular phenotype, enabling a deeper understanding of the impact of environmental exposures on cellular function and disease pathogenesis …”

Section: Spatial Single-cell Exposomicsmentioning

confidence: 99%

“…Single-cell exposomics offers significant potential because it provides insights into how individual cells respond to environmental stimuli, aiding in the understanding of the initiation, progression, or prevention of diseases. The cells’ interactions with their environment form the basis for understanding the organism’s overall health and disease state . Observing how each cell responds to environmental stimuli helps us uncover the interplay of genetic and environmental factors that lead to varying disease susceptibilities and biological responses among individuals.…”

Section: Introductionmentioning

confidence: 99%

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Exploring Single-Cell Exposomics by Mass Spectrometry

Gao

2023

Environ. Sci. Technol.

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Single-cell exposomics, a revolutionary approach that investigates cell−environment interactions at cellular and subcellular levels, stands distinct from conventional bulk exposomics. Leveraging advancements in mass spectrometry, it provides a detailed perspective on cellular dynamics, interactions, and responses to environmental stimuli and their impacts on human health. This work delves into this innovative realm, highlighting the nuanced interplay between environmental stressors and biological responses at cellular and subcellular levels. The application of spatial mass spectrometry in single-cell exposomics is discussed, revealing the intricate spatial organization and molecular composition within individual cells. Cell-type-specific exposomics, shedding light on distinct susceptibilities and adaptive strategies of various cell types to environmental exposures, is also examined. The Perspective further emphasizes the integration with molecular and cellular biology approaches to validate hypotheses derived from single-cell exposomics in a comprehensive biological context. Looking toward the future, we anticipate continued technological advancements and convergence with other -omics approaches and discuss implications for environmental health research, disease progression studies, and precision medicine. The final emphasis is on the need for robust computational tools and interdisciplinary collaboration to fully leverage the potential of single-cell exposomics, acknowledging the complexities inherent to this paradigm.

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