2020
DOI: 10.21203/rs.3.rs-89815/v1
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Exposure of Mesenchymal Stem Cells to an Alzheimer’s Disease Environment Enhances Therapeutic Effects

Abstract: BackgroundMesenchymal stem cells (MSCs) have emerged as a promising tool for the treatment of Alzheimer’s disease (AD). Previous studies suggested that the co-culture of human MSCs with AD in an in vitro model reduced the expression of amyloid-beta 42 (Aβ42) in the medium as well as the overexpression of amyloid-beta (Aβ )-degrading enzymes such as neprilysin (NEP).MethodsIn this study, we focused on the role of primed MSCs (human Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) exposed to an AD cell l… Show more

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“…Although both showed promising results in reducing cell death, ubiquitin conjugate levels, and Aβ levels, "prime" human WJ-MSCs showed greater results. This suggests that exposure of human WJ-MSCs to an AD environment improves its therapeutic effects [34].…”
Section: Preclinical Studiesmentioning
confidence: 99%
“…Although both showed promising results in reducing cell death, ubiquitin conjugate levels, and Aβ levels, "prime" human WJ-MSCs showed greater results. This suggests that exposure of human WJ-MSCs to an AD environment improves its therapeutic effects [34].…”
Section: Preclinical Studiesmentioning
confidence: 99%