Exposure to alternative bisphenols BPS and BPF through breast milk: Noxious heritage effect during nursing associated with idiopathic infertility

Nevoral, Jan; Havránková, Jiřina; Kolinko, Yaroslav; Prokešová, Šárka; Fenclová, Tereza; Monsef, Ladan; Žalmanová, Tereza; Petr, Jaroslav; Králíčková, Milena

doi:10.1016/j.taap.2021.115409

Cited by 22 publications

(14 citation statements)

References 59 publications

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“…Mouse ovaries (B) Discover the effects of exposure to bisphenol A analogs during breastfeeding on ovarian capacity of offspring. The quantification of primordial, primary, preantral, antral and atretic follicles (Nevoral et al, 2021).…”

Section: #S9mentioning

confidence: 99%

Using virtual microscopy for the development of sampling strategies in quantitative histology and design‐based stereology

Kolinko

Malečková

Kochová

et al. 2021

Anat Histol Embryol

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Only a fraction of specimens under study are usually selected for quantification in histology. Multilevel sampling or tissue probes, slides and fields of view (FOVs) in the regions of interest (ROIs) are required. In general, all parts of the organs under study should be given the same probability to be taken into account; that is, the sampling should be unbiased on all levels. The objective of our study was to provide an overview of the use of virtual microscopy in the context of developing sampling strategies of FOVs for stereological quantification. We elaborated this idea on 18 examples from

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Section: #S9mentioning

confidence: 99%

Using virtual microscopy for the development of sampling strategies in quantitative histology and design‐based stereology

Kolinko

Malečková

Kochová

et al. 2021

Anat Histol Embryol

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“…Moreover, newborns do not have fully developed elimination mechanisms involving detoxification in the liver and/or the glucuronidation pathway in the kidney (Matalová et al, 2016). Although the chosen dosage was extremely low in accordance with the actual exposure (González et al, 2020;Gys et al, 2020;Kim et al, 2020;Luo et al, 2021), we expected higher intake per gram of body weight of infants, leading to significant damage to germ cells and fertility while achieving adulthood, as indicated earlier in our previous findings (Nevoral et al, 2021).…”

Section: Discussionmentioning

confidence: 72%

Nursing Exposure to Bisphenols as a Cause of Male Idiopathic Infertility

et al. 2022

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Idiopathic infertility is a serious problem, which can be caused and explained by exposure to endocrine disruptors, such as bisphenols. In our study, we studied transactional exposure to bisphenol and its effects on newborn male mice throughout their reproductive life. Newborn male mice were exposed to bisphenol S and bisphenol F through maternal milk from post-natal day 0 to post-natal day 15 at concentrations of 0.1 ng.g/bw/day and 10 ng.g/bw/day, respectively. Although there were minimal differences between the control and experimental groups in testicular tissue quality and spermatozoa quality, we discovered an interesting influence on early embryonic development. Moderate doses of bisphenol negatively affected cleavage of the early embryo and subsequently, the blastocyst rate, as well as the number of blastomeres per blastocyst. In our study, we focused on correlations between particular stages from spermatogenesis to blastocyst development. We followed epigenetic changes such as dimethylation of histone H3 and phosphorylation of histone H2 from germ cells to blastocysts; we discovered the transfer of DNA double-strand breaks through the paternal pronucleus from spermatozoa to blastomeres in the blastocyst. We elucidated the impact of sperm DNA damage on early embryonic development, and our results indicate that idiopathic infertility in adulthood may have causes related to the perinatal period.

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“…Recently, a study has described that maternal BPF exposure through breast milk deprived the quality and maturity of oocytes 32 . We first investigated the effect of BPF on PBE, a commonly used marker of oocyte meiotic maturation.…”

Section: Discussionmentioning

confidence: 99%

Bisphenol F exposure affects mouse oocyte in vitro maturation through inducing oxidative stress and DNA damage

Ding

Chen

Ahmad

et al. 2022

Environmental Toxicology

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Bisphenol F (BPF), a substitute for bisphenol A (BPA), is progressively used to manufacture various consumer products. Despite the established reproductive toxicity of BPF, the underlying mechanisms remain to elucidate. This in‐vitro study deep in sighted the BPF toxicity on mouse oocyte meiotic maturation and quality. After treating oocytes with BPF (300 μM), the oocyte meiotic progression was blocked, accentuated by a reduced rate in the first polar body extrusion (PBE). Next, we illustrated that BPF induced α‐tubulin hyper‐acetylation disrupted the spindle assembly and chromosome alignment. Concurrently, BPF resulted in severe oxidative stress and DNA damage, which triggered the early apoptosis in mouse oocytes. Further, altered epigenetic modifications following BPF exposure were proved by increased H3K27me3 levels. Concerning the toxic effects on spindle structure, oxidative stress, and DNA damage in mouse oocytes, BPF toxicity was less severe to oocyte maturation and spindle structure than BPA and induced low oxidative stress. However, compared with BPA, oocytes treated with BPF were more prone to DNA damage, indicating not less intense or even more severe toxic effects of BPF than BPA on some aspects of oocytes maturation. In brief, the present study established that like wise to BPA, BPF could inhibit meiotic maturation and reduce oocyte quality, suggesting it is not a safe substitute for BPA.

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Exposure to alternative bisphenols BPS and BPF through breast milk: Noxious heritage effect during nursing associated with idiopathic infertility

Cited by 22 publications

References 59 publications

Using virtual microscopy for the development of sampling strategies in quantitative histology and design‐based stereology

Using virtual microscopy for the development of sampling strategies in quantitative histology and design‐based stereology

Nursing Exposure to Bisphenols as a Cause of Male Idiopathic Infertility

Bisphenol F exposure affects mouse oocyte in vitro maturation through inducing oxidative stress and DNA damage

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