Exposure to Aroclor 1254 differentially affects the survival of pancreatic β-cells and α-cells in the male mice and the potential reason

Fang, Lü; Zhang, Shiqi; Ou, Kunlin; Zuo, Zhenghong; Yu, Ang; Wang, Chonggang

doi:10.1016/j.ecoenv.2019.109875

Cited by 12 publications

(11 citation statements)

References 73 publications

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“…Nonetheless, some possible mechanisms are proposed and discussed. In the study by Fang et al [ 76 ], it was postulated that the decreased alpha-cell mass due to exposure to Aroclor 1254 was related to down-regulated expression of the aristaless-related homeobox (ARX), which is a protein encoded by the homonymous gene. As regards the studies focusing on in utero exposures, in the study by Santos-Silva et al [ 77 ], it was reported that the observed changes in the morphology of the alpha cell due to dexamethasone exposure were paralleled by a persistent increase in proglucagon gene (GCG) protein expression.…”

Section: Discussionmentioning

confidence: 99%

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Chemical Compounds and Ambient Factors Affecting Pancreatic Alpha-Cells Mass and Function: What Evidence?

Mannino

Mancuso

Sbrignadello

et al. 2022

IJERPH

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The exposure to different substances present in the environment can affect the ability of the human body to maintain glucose homeostasis. Some review studies summarized the current evidence about the relationships between environment and insulin resistance or beta-cell dysfunction. Instead, no reviews focused on the relationships between the environment and the alpha cell, although in recent years clear indications have emerged for the pivotal role of the alpha cell in glucose regulation. Thus, the aim of this review was to analyze the studies about the effects of chemical, biological, and physical environmental factors on the alpha cell. Notably, we found studies focusing on the effects of different categories of compounds, including air pollutants, compounds of known toxicity present in common objects, pharmacological agents, and compounds possibly present in food, plus studies on the effects of physical factors (mainly heat exposure). However, the overall number of relevant studies was limited, especially when compared to studies related to the environment and insulin sensitivity or beta-cell function. In our opinion, this was likely due to the underestimation of the alpha-cell role in glucose homeostasis, but since such a role has recently emerged with increasing strength, we expect several new studies about the environment and alpha-cell in the near future.

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Section: Discussionmentioning

confidence: 99%

“…The study by Fang et al in 2020 [ 76 ] was interested in the effects of environmental pollutants on the alpha cell (and beta cell as well). Specifically, the focus was on Aroclor 1254, which is a polychlorinated biphenyl mixture.…”

Section: Chemical and Biological Compounds Effect On The Alpha Cellmentioning

confidence: 99%

Chemical Compounds and Ambient Factors Affecting Pancreatic Alpha-Cells Mass and Function: What Evidence?

Mannino

Mancuso

Sbrignadello

et al. 2022

IJERPH

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“…Literature shows that the direct action of PCBs on islet cells is one of the most important factors in promoting T2DM. 23,91 The primary functional types of the Langerhans islet cells are α cells, which secrete glucagon, β cells, which secrete insulin, D cells, which emit somatostatin, and PP cells, which secrete pancreatic polypeptide. β cells as the main core cells that have a key role in blood sugar regulation are surrounded by other cells.…”

Section: Pcbs Exposure Affected In Insulin Secretionmentioning

confidence: 99%

“…and estrogen receptor α/β (ERα/β) to increase the mass of β cells and insulin synthesis. 23,91,95 AR and PDX-1…”

Section: Pcbs Exposure Affected In Insulin Secretionmentioning

confidence: 99%

Polychlorinated biphenyls exposure and type 2 diabetes: Molecular mechanism that causes insulin resistance and islet damage

Shan,

Liu,

et al. 2024

Environmental Toxicology

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Polychlorinated biphenyls (PCBs) are typical persistent organic pollutants that have been associated with type 2 diabetes (T2DM) in cohort studies. This review aims to comprehensively assess the molecular mechanisms of PCBs‐induced T2DM. Recent progress has been made in the research of PCBs in liver tissue, adipose tissue, and other tissues. By influencing the function of nuclear receptors, such as the aryl hydrocarbon receptor (AhR), pregnancy X receptor (PXR), and peroxisome proliferator activated receptor γ (PPARγ), as well as the inflammatory response, PCBs disrupt the balance of hepatic glucose and lipid metabolism. This is associated with insulin resistance (IR) in the target organ of insulin. Through androgen receptor (AR), estrogen receptor α/β (ERα/β), and pancreato‐duodenal‐homeobox gene‐1 (PDX‐1), PCBs affect the secretion of insulin and increase blood glucose. Thus, this review is a discussion on the relationship between PCBs exposure and the pathogenesis of T2DM. It is hoped to provide basic concepts for diabetes research and disease treatment.

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“…Only one research group assessed islet cell proliferation following prolonged low-dose Aroclor exposure in male mice in vivo; they found increased β-cell area and proliferation and decreased α-cell area but no change in α-cell proliferation ( Fig. 6 ) ( 160 , 161 , 167 ). These data are consistent with the hyperinsulinemia observed in vivo ( 160 – 162 ), but whether this increase in β-cell proliferation is an adaptive response to β-cell loss and/or dysfunction remains unclear.…”

Section: Polychlorinated Biphenylsmentioning

confidence: 99%

Persistent organic pollutants and β-cell toxicity: a comprehensive review

Hoyeck

Matteo

MacFarlane

et al. 2022

American Journal of Physiology-Endocrinology and Metabolism

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Persistent organic pollutants (POPs) are a diverse family of contaminants that show widespread global dispersion and bioaccumulation. Humans are continuously exposed to POPs through diet, air particles, and household and commercial products; POPs are consistently detected in human tissues, including the pancreas. Epidemiological studies show a modest but consistent correlation between exposure to POPs and increased diabetes risk. The goal of this review is to provide an overview of epidemiological evidence and an in-depth evaluation of the in vivo and in vitro evidence for POPs as potential b-cell toxins. We review evidence for 6 classes of POPs: dioxins, polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), organophosphate pesticides (OPPs), flame retardants, and per- and polyfluoroalkyl substances (PFAS). The available data provide convincing evidence implicating POPs as a contributing factor driving impaired glucose homeostasis, b-cell dysfunction, and altered metabolic and oxidative stress pathways in islets. These findings support epidemiological data showing that POPs increase diabetes risk and emphasize the need to consider the endocrine pancreas in toxicity assessments. However, our review also highlights significant gaps in the literature assessing islet-specific endpoints following both in vivo and in vitro POP exposure. In addition, most rodent studies do not consider the impact of biological sex or secondary metabolic stressors in mediating the effects of POPs on glucose homeostasis and b-cell function. We discuss key gaps and limitations that should be assessed in future studies.

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Exposure to Aroclor 1254 differentially affects the survival of pancreatic β-cells and α-cells in the male mice and the potential reason

Cited by 12 publications

References 73 publications

Chemical Compounds and Ambient Factors Affecting Pancreatic Alpha-Cells Mass and Function: What Evidence?

Chemical Compounds and Ambient Factors Affecting Pancreatic Alpha-Cells Mass and Function: What Evidence?

Polychlorinated biphenyls exposure and type 2 diabetes: Molecular mechanism that causes insulin resistance and islet damage

Persistent organic pollutants and β-cell toxicity: a comprehensive review

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