Exposure to Bisphenol A and phthalates metabolites in the third trimester of pregnancy and BMI trajectories

Yang, Tiffany; Peterson, Karen E.; Meeker, John D.; Sánchez, Brisa N.; Zhang, Z.; Cantoral, Alejandra; Solano, Maritsa; Téllez‐Rojo, Martha María

doi:10.1111/ijpo.12279

Cited by 39 publications

(41 citation statements)

References 32 publications

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“…HMWPm with BMI z-scores in boys HMWPm with BMI z-scores in girls (53) MiBP, MBzP, MEHP and MECPP with BMI trajectories in males MECPP with BMI trajectories in female (107) factor expression in mice (108). Most epidemiological studies in humans found that exposure to LMWP metabolites, such as MEP, MBP, MiBP, and HMWP metabolites, MEHHP, and MEOHP, were negatively related to birth weight (82,85,(89)(90)(91)(92)(93)(94)(95)(96), birth length (89,91,95), and circumferences of head, chest or abdominal (84,85,91,94,96,98).…”

Section: Prenatal Phthalate Exposure and Fetal Growthmentioning

confidence: 99%

“…On the contrary, other studies reported inverse or null associations between prenatal phthalate exposure and child's growth (53,(102)(103)(104)(105)(106)(107). One prospective study showed that maternal urinary concentrations of non-DEHP metabolites before delivery, but not DEHP metabolites, were related to a decrease in fat mass, waist circumference, and BMI Z scores of boys at 5 and 7 years ages (102).…”

Section: Prenatal Phthalate Exposure and Child's Growthmentioning

confidence: 99%

“…Those studies, examining the phthalate metabolites in maternal urine samples, maternal meconium or cord blood, reported inverse (82,84,85,(89)(90)(91)(92)(93)(94)(95)(96)(97)(98), null (68,72,79,83,99), and positive (85,97) associations between women exposed to phthalates and its fetal growth. Moreover, a few longitudinal studies (97,(100)(101)(102)(103)(104)(105)(106)(107) had assessed associations of certain phthalate exposure during pregnancy and BMI, waist circumference, and risk of overweight/obesity in childhood, and the findings were inconsistent and often sexspecific ( Table 4).…”

Section: Prenatal Phthalate Exposure and Growth Of Fetal And Childmentioning

confidence: 99%

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The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

Qian

Shao

Ying

et al. 2020

Front. Public Health

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Phthalates are a group of ubiquitous synthetic endocrine-disrupting chemicals. Fetal and neonatal periods are particularly susceptible to endocrine disorders, which prenatal exposure to phthalates causes. There is increasing evidence concerning the potential endocrine disrupting for phthalate exposure during pregnancy. This article aims to review the endocrine impairment and potential outcomes of prenatal phthalate exposure. Prenatal exposure phthalates would disrupt the levels of thyroid, sex hormone, and 25-hydroxyvitamin D in pregnant women or offspring, which results in preterm birth, preeclampsia, maternal glucose disorders, infant cryptorchidism, infant hypospadias, and shorter anogenital distance in newborns, as well as growth restriction not only in infants but also in early adolescence and childhood. The relationship of prenatal phthalate exposure with maternal and neonatal outcomes in human beings was often sex-specific associations. Because of the potentially harmful influence of prenatal phthalate exposure, steps should be taken to prevent or reduce phthalate exposure during pregnancy.

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Section: Prenatal Phthalate Exposure and Fetal Growthmentioning

confidence: 99%

Section: Prenatal Phthalate Exposure and Child's Growthmentioning

confidence: 99%

Section: Prenatal Phthalate Exposure and Growth Of Fetal And Childmentioning

confidence: 99%

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The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

Qian

Shao

Ying

et al. 2020

Front. Public Health

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“…Individual phthalate metabolite concentrations and molar sum derivatives were natural-log transformed to achieve a normal distribution. All analyses were sex-stratified because phthalate metabolites were previously shown to have sex-specific effects on children's adiposity and on DNA methylation (10, 11, 20). Means, standard deviation (SD), and distributions of phthalate metabolites (geometric means), DNA methylation data, anthropometric outcomes, and maternal education were calculated.…”

Section: Methodsmentioning

confidence: 99%

“…Our prior research in the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) project identified associations between phthalate exposure and DNA methylation of H19 and HSD11B2 (20) as well as between phthalate exposure and weight status and adiposity at one childhood time point (10, 11). This study aims to extend the evaluation of phthalate exposures and peri-adolescent adiposity to include trimester-specific measures across pregnancy and repeat measures of adiposity in ELEMENT children.…”

Section: Introductionmentioning

confidence: 99%

Phthalate Exposures, DNA Methylation and Adiposity in Mexican Children Through Adolescence

Bowman

Peterson

Dolinoy

et al. 2019

Front. Public Health

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Phthalates are a class of endocrine disrupting chemicals with near ubiquitous exposure to populations around the world. Phthalates have been associated with children's adiposity in previous studies, though discrepancies exist across studies that may be due to timing of exposure or outcome assessment and population differences (i.e., genetics, other confounders). DNA methylation, an epigenetic modification involved in gene regulation, may mediate the effects of early life phthalate exposures on health outcomes. This study aims to evaluate the mediating effect of DNA methylation at growth-related genes on the association between phthalate exposure and repeat measures of adiposity (BMI-for-age z-score, waist circumference, and skinfolds thickness) in Mexican children. Urinary phthalate metabolite concentrations were quantified in mothers at each of the three trimesters of pregnancy and in children at the first peri-adolescent study visit. Blood leukocyte DNA methylation at H19 and HSD11B2 was quantified during the first peri-adolescent visit, and adiposity was measured at the first visit and again ~3 years later among participants ( n = 109 boys, 114 girls) from the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) project. Associations between phthalates or DNA methylation and repeat outcome measures were assessed separately in boys and girls using generalized estimating equation models including covariates (urinary specific gravity, maternal education, and child's age). Sobel tests were used to assess DNA methylation as a mediator in models adjusting for the same covariates. Associations between phthalates and adiposity varied by phthalate and timing of exposure. Early gestation MBP, MIBP, and MBzP were associated with adiposity among girls. For example, among girls first trimester maternal urine concentrations of MIBP were associated with increases in skinfold thickness, BMI-for-age, and waist circumference ( p < 0.01). Second trimester and adolescent MBzP were associated with adiposity among boys in opposite directions. In girls, H19 methylation was positively associated with skinfold thickness. No significant mediation of phthalate exposure on adiposity by DNA methylation of H19 or HSD11B2 was observed (Sobel p > 0.05). However, the mediation analysis was underpowered to detect small to medium effect sizes, and the role of DNA methylation as a mediator between phthalates and outcomes merits further study.

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How microplastic components influence the immune system and impact on children health: Focus on cancer

Segovia-Mendoza

Nava-Castro

Palacios-Arreola

et al. 2020

Birth Defects Research

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Background: As a result of human socioeconomic activity, industrial wastes have increased distressingly. Plastic pollution is globally distributed across the world due to its properties of buoyancy and durability. A big health hazard is the sorption of toxicants to plastic while traveling through the environment. Two broad classes of plastic-related chemicals are of critical concern for human health-bisphenols and phthalates. Bisphenol A (BPA) is an endocrine-disruptor compound (EDC) with estrogenic activity. It is used in the production of materials that are used daily. The endocrine modulating activity of BPA and its effects on reproductive health has been widely studied. BPA also has effects on the immune system; however, they are poorly investigated and the available data are inconclusive. Phthalates are also EDCs used as plasticizers in a wide array of daily-use products. Since these compounds are not covalently bound to the plastic matrix, they easily leach out from it, leading to high human exposure. These compounds exert several cell effects through modulating different endocrine pathways, such as estrogen, androgen, peroxisome proliferator-activated receptor gamma, and arylhydrocarbon receptor pathways. The exposure to both classes of plastic derivatives during critical periods has detrimental effects on human health. Methods: In this review, we have compiled the most important of their perinatal effects on the function of the immune system and their relationship to the development of different types of cancer. Results/Conclusion: The administration of bisphenols and phthalates during critical stages of development affects important immune system components, and the immune function; which might be related to the development of different diseases including cancer.

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Exposure to Bisphenol A and phthalates metabolites in the third trimester of pregnancy and BMI trajectories

Abstract: These results suggest sex-specific differences in BMI trajectories by levels of metabolite exposure. Additional studies are needed to consider growth through adolescence in assessing the association of pregnancy exposures on child's BMI.

Cited by 39 publications

References 32 publications

The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

Phthalate Exposures, DNA Methylation and Adiposity in Mexican Children Through Adolescence

How microplastic components influence the immune system and impact on children health: Focus on cancer

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