Exposure to bisphenol A and its analogs and polycystic ovarian syndrome in women of childbearing age: A multicenter case-control study

Zhan, Wenqiang; Tang, Weifeng; Shen, Xiaoli; Xu, Hong; Zhang, Jun

doi:10.1016/j.chemosphere.2022.137463

Cited by 27 publications

(10 citation statements)

References 71 publications

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“…More intricate research has indicated that ancestral exposure to BPA can induce PCOS-like phenotypes in subsequent unexposed generations by activating cancerous pathways, altering arginine-proline metabolism, insulin signaling, AMPK, HOTAIR regulatory pathways, as well as modulating the upstream regulators ESR1 and TGF signaling in the ovary (97). Moreover, a randomized controlled experiment found higher serum levels of BPA replacement chemicals in women with PCOS (98, which is supported by similar findings in a case-control study (99).…”

Section: Bpamentioning

confidence: 72%

The adverse role of endocrine disrupting chemicals in the reproductive system

Pan,

Liu,

et al. 2024

Front. Endocrinol.

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Reproductive system diseases pose prominent threats to human physical and mental well-being. Besides being influenced by genetic material regulation and changes in lifestyle, the occurrence of these diseases is closely connected to exposure to harmful substances in the environment. Endocrine disrupting chemicals (EDCs), characterized by hormone-like effects, have a wide range of influences on the reproductive system. EDCs are ubiquitous in the natural environment and are present in a wide range of industrial and everyday products. Currently, thousands of chemicals have been reported to exhibit endocrine effects, and this number is likely to increase as the testing for potential EDCs has not been consistently required, and obtaining data has been limited, partly due to the long latency of many diseases. The ability to avoid exposure to EDCs, especially those of artificially synthesized origin, is increasingly challenging. While EDCs can be divided into persistent and non-persistent depending on their degree of degradation, due to the recent uptick in research studies in this area, we have chosen to focus on the research pertaining to the detrimental effects on reproductive health of exposure to several EDCs that are widely encountered in daily life over the past six years, specifically bisphenol A (BPA), phthalates (PAEs), polychlorinated biphenyls (PCBs), parabens, pesticides, heavy metals, and so on. By focusing on the impact of EDCs on the hypothalamic-pituitary-gonadal (HPG) axis, which leads to the occurrence and development of reproductive system diseases, this review aims to provide new insights into the molecular mechanisms of EDCs’ damage to human health and to encourage further in-depth research to clarify the potentially harmful effects of EDC exposure through various other mechanisms. Ultimately, it offers a scientific basis to enhance EDCs risk management, an endeavor of significant scientific and societal importance for safeguarding reproductive health.

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Section: Bpamentioning

confidence: 72%

The adverse role of endocrine disrupting chemicals in the reproductive system

Pan,

Liu,

et al. 2024

Front. Endocrinol.

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“…Indeed, it has been recently shown that total phthalate metabolites urine concentrations were positively associated with BMI, lipid accumulation product and significantly linked with fasting plasma glucose [41] . In a case-control study, Zhan et al showed that environmental exposure to bisphenol analogs was associated with increased odds of PCOS and this association was stronger among obese and overweight women [72] . Moreover, in this study, we only analysed individual pesticide effect which is not relevant regarding realistic exposure scenarios.…”

Section: Discussionmentioning

confidence: 99%

The epoxiconazole and tebuconazole fungicides impair granulosa cells functions partly through the aryl hydrocarbon receptor (AHR) signalling with contrasted effects in obese, normo-weight and polycystic ovarian syndrome (PCOS) patients

Serra,

Estienne,

Bongrani

et al. 2024

Toxicology Reports

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“…CALP10 has been found to be the best predictor for assessing genetic SNPs in women with PCOS as CALP10 is a validated marker for T2DM ( 7 ). In the present study, a positive association was found between UCSNPs 43, 44, 56, and 63.…”

Section: Discussionmentioning

confidence: 99%

“…The global prevalence of PCOS in the female population is 5–21% depending on the diagnostic criteria utilized ( 7 ). PCOS was first diagnosed in 1990 by the NICHD.…”

Section: Introductionmentioning

confidence: 99%

Molecular role of non-exonic variants in CALPAIN 10 gene in polycystic ovarian syndrome in Saudi women

Alageel,

Alshammary,

Ali Khan

2023

Front. Endocrinol.

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IntroductionNon-diabetic women with polycystic ovarian syndrome (PCOS) often have abnormal insulin regulation. Calpain 10 (CALP10) is a biomarker of type 2 diabetes mellitus, with some of its single-nucleotide polymorphisms (SNPs) influencing PCOS development.MethodsIn this case-control study on 90 women each with and without PCOS, we explored the molecular role of five CALP10 SNPs using biochemical parameters and Sanger sequencing analyses.ResultsDifferent genetic models, genotypes, and allele frequencies were significantly associated with UCSNP-19 (rs3842570; p=0.01), UCSNP-44 (rs2975760; p=0.009), UCSNP-56 (rs2975762; p<0.0001), and UCSNP-63 (rs5030952; p=0.0003) in women with PCOS. The multiple logistic regression model showed a strong association of CALP10 SNPs with fasting blood glucose (p<0.001). ANOVA showed significant associations with various biochemical parameters such as FSH (p=0.0001) in UCSNP-19 (rs3842570), FI (p=0.002), TG (p=0.01) in UCSNP-56 (rs2975762) and FBG (p=0.001), FI (p=0.004), FSH (p=0.02) & LDLc (p=0.04) in UCSNP-63 (rs5030952) SNPs. Haplotype analysis also revealed significant associations between different combinations of alleles in the studied 5 SNPs in women with PCOS (p<0.05). Generalized multifactor dimensionality reduction analysis showed the best gene–gene interactions among the five SNPs in CALP10I (p<0.05). However, dendrogram and graphical depletion models found no strong association in women with PCOS.ConclusionIn conclusion, this study confirms rs3842570, rs2975760, rs2975767, and rs5030952 SNPs in CALP10 gene is associated in diagnosed PCOS women in the Saudi Arabia.

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Exposure to bisphenol A and its analogs and polycystic ovarian syndrome in women of childbearing age: A multicenter case-control study

Cited by 27 publications

References 71 publications

The adverse role of endocrine disrupting chemicals in the reproductive system

The adverse role of endocrine disrupting chemicals in the reproductive system

The epoxiconazole and tebuconazole fungicides impair granulosa cells functions partly through the aryl hydrocarbon receptor (AHR) signalling with contrasted effects in obese, normo-weight and polycystic ovarian syndrome (PCOS) patients

Molecular role of non-exonic variants in CALPAIN 10 gene in polycystic ovarian syndrome in Saudi women

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