Exposure to cadmium in male urban and rural workers and effects on FSH, LH and testosterone

Ciarrocca, Manuela; Capozzella, Assunta; Tomei, Francesco; Tomei, Gianfranco; Caciari, Tiziana

doi:10.1016/j.chemosphere.2012.10.060

Cited by 61 publications

(38 citation statements)

References 57 publications

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“…It suppressed serum prolactin, LH, FSH, and GH. This was in agree with other studies in both human [4] and animal [24]. Also, Cd produced oxidative load on the pituitary gland cell.…”

Section: Discussionsupporting

confidence: 83%

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Protective Effect of Montelukast against Cadmium Induced Pituitary Gland Toxicity

Ek¹,

Mf²,

Mg³

et al. 2017

IJCPT

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Adult male Sprague rats weighting (220 ± 30gm) were purchased from Faculty of Agriculture, Minia University Egypt. Experimen- AbstractCadmium (Cd) is a common environmental hazardous heavy metal. The standard treatment of heavy metal intoxication; chelators may have a minor role in Cd toxicity. Montelukast (ML) is an anti-inflammatory drug that is used mainly for managing asthmatic patients. Recent workers have tested ML for its antioxidant properties in various conditions and obtained encouraging results as regarding this effect. We investigated the protective and antioxidant effect of ML on pituitary gland, a highly sensitive organ to Cd toxicity. Four groups of rats were used and received distilled water, 10mg/kg ML, 3mg/kg Cd, and 10mg ML plus 3mg/kg Cd respectively. Antioxidant, histological, immunohistochemical and hormonal effects of Cd and ML were evaluated. The detrimental effect of Cd on pituitary gland was abolished by ML. The diminished hormonal effect of Cd was restored to normal levels. The increased MDA level and depleted oxidative enzymes on pituitary gland of rat exposed to Cd were restored by ML. lastly, histological and apoptotic effects of Cd were also, corrected significantly by ML. It is concluded that ML can protect against Cd-induced pituitary gland toxicity.

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“…It suppressed serum prolactin, LH, FSH, and GH. This was in agree with other studies in both human [4] and animal [24]. Also, Cd produced oxidative load on the pituitary gland cell.…”

Section: Discussionsupporting

confidence: 83%

“…So, we could be exposed to this metal environmentally, occupational and by diet. Cd has serious health hazards that affect most of the tissue types of the human body including reproductive function [2] liver [3] pancreas [4], heart [5] and nervous system [6]. It has been classified as class I human carcinogenic agent [1].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Montelukast against Cadmium Induced Pituitary Gland Toxicity

Ek¹,

Mf²,

Mg³

et al. 2017

IJCPT

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“…Similarly, urinary cadmium level was also not associated with sex steroid hormone concentration in a large, nationally representative sample of US men (Menke et al 2008). On the contrary, other studies showed significant effect of blood/urinary lead or cadmium levels on sex steroid hormones in environmentally or occupationally exposed Chinese (Zeng et al 2002(Zeng et al , 2004, Italian (Ciarrocca et al 2013), Croatian (Telisman et al 2000;Jurasovic et al 2004), and US men (Meeker et al 2010). Thus, studies investigating the association have been inconsistent, finding either no association or a positive association.…”

Section: Discussionmentioning

confidence: 76%

Reproductive toxicity of lead, cadmium, and phthalate exposure in men

Pant

Kumar

Upadhyay

et al. 2014

Environ Sci Pollut Res

114

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Environmental toxicants viz lead or cadmium and phthalate esters (di(2-ethylhexyl) phthalate [DEHP], dibutyl phthalate [DBP], and diethyl phthalate [DEP]) widely found in different environmental strata are linked to deteriorating male reproductive health. The objective was to assess the relationships between the seminal lead, cadmium, and phthalate (DEHP, DBP, DEP) concentrations at environmental level and serum hormone levels and semen quality in non-occupationally exposed men and specify the effect of individual and combined exposure of toxicants on semen quality. A study of 60 male partners of couples attending the Andrology Laboratory of the Reproductive Biology Department, All India Institute of Medical Sciences (AIIMS), New Delhi, India for semen analysis to assess their inability to achieve a pregnancy was selected for the study. The results of univariate and stepwise multiple regression analysis in the unadjusted model showed a significant correlation between lead or cadmium and phthalates DEHP/DBP/DEP and sperm motility, sperm concentration, and DNA damage. After adjusting for potential confounders, an association with lead or DEHP was only observed. The present data shows that lead (Pb) or cadmium (Cd) or phthalates might independently contribute to decline in semen quality and induce DNA damage. Phthalates might influence reproductive hormone testosterone. These findings are significant in light of the fact that men are exposed to a volley of chemicals; however, due to the small sample size, our finding needs to be confirmed in a larger population.

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“…In Italy, Cd emissions in the atmosphere increased from 7.4 tons in 2002 to 8.8 tons in 2007 (Ciarrocca et al, 2013;ISTAT, 2008). Cd levels in air generally range from 2 ng m À3 to 15 ng m À3 (Ciarrocca et al, 2013;Goforth and Christoforou, 2006) . In our study, the exposure of PM agents to the environmental Cd was low, and the values obtained are in fact lower than the limit value of 0.01 mg m À3 proposed by the ACGIH for individuals occupationally exposed to Cd and lower than the level of the exposure of industrial workers (ATSDR, 2012;Ding et al, 2011).…”

Section: Discussionmentioning

confidence: 98%

Correlation between urinary cadmium and thyroid hormones in outdoor workers exposed to urban stressors

et al. 2016

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Exposure to cadmium in male urban and rural workers and effects on FSH, LH and testosterone

Cited by 61 publications

References 57 publications

Protective Effect of Montelukast against Cadmium Induced Pituitary Gland Toxicity

Protective Effect of Montelukast against Cadmium Induced Pituitary Gland Toxicity

Reproductive toxicity of lead, cadmium, and phthalate exposure in men

Correlation between urinary cadmium and thyroid hormones in outdoor workers exposed to urban stressors

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