Exposure to different PM2.5 extracts induces gliosis and changes behavior in male rats similar to autism spectrum disorders features

Rahmatinia, Masoumeh; Mohseni-Bandpei, Anoushiravan; Khodagholi, Fariba; Abdollahifar, Mohammad-Amin; Amouei Torkmahalleh, Mehdi; Hassani Moghaddam, Meysam; Hopke, Philip K.; Ghavimehr, Ehsan; Bazzazpour, Shahriyar; Shahsavani, Abbas

doi:10.1016/j.envpol.2023.122804

Environmental Pollution

2024

DOI: 10.1016/j.envpol.2023.122804

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Exposure to different PM2.5 extracts induces gliosis and changes behavior in male rats similar to autism spectrum disorders features

Masoumeh Rahmatinia,

Anoushiravan Mohseni-Bandpei,

Fariba Khodagholi

et al.

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2024

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Cited by 2 publications

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PM2.5 induces developmental neurotoxicity in cortical organoids

Han,

Yu,

Chen

et al. 2024

Environmental Pollution

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PM2.5 induces developmental neurotoxicity in cortical organoids

Han,

Yu,

Chen

et al. 2024

Environmental Pollution

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Neuroprotective effects of fermented blueberry and black rice against particulate matter 2.5 μm-induced inflammation in vitro and in vivo

Bayazid,

Jeong,

Azam

et al. 2024

Drug and Chemical Toxicology

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The escalating prevalence of particulate matter (PM) has raised serious concerns regarding its detrimental effects on human health. This study aimed to investigate the potential of fermented blueberry and black rice (FBBR) in mitigating the effects of PM2.5, both in SH-SY5Y cells and mice exposed to PM2.5. Various assays, including MTT, NO, western blot, ELISA, and behavioral studies (MWM and Y-maze) were conducted. Our results demonstrated that PM2.5 induced significant cytotoxicity and elevated nitric oxide (NO) production at a concentration of 100μg/mL of PM2.5 in SH-SY5Y cells. Additionally, administration of FBBR effectively attenuated PM2.5-induced cytotoxicity and suppressed NO production in SH-SY5Y cells. In an intranasal instilled mice model, exposure to 10 mg/kg body weight of PM2.5 resulted in cognitive impairments. However, FBBR treatment ameliorated these impairments in both the Y-maze and MWM tests in PM2.5-exposed mice. Furthermore, FBBR administration increased the expression of brain-derived neurotrophic factor (BDNF) and reduced inflammatory markers in the brains of PM2.5-exposed SH-SY5Y cells. These findings underscore the detrimental effects of PM2.5 on the nervous system and highlight the potential of FBBR as a nutraceutical agent for mitigating these effects. Overall, this study emphasizes the urgency of addressing the harmful impact of PM2.5 on the nervous system and suggests the promising role of FBBR as a protective intervention against the adverse effects associated with PM2.5 exposure.

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Exposure to different PM2.5 extracts induces gliosis and changes behavior in male rats similar to autism spectrum disorders features

Cited by 2 publications

References 64 publications

PM2.5 induces developmental neurotoxicity in cortical organoids

PM2.5 induces developmental neurotoxicity in cortical organoids

Neuroprotective effects of fermented blueberry and black rice against particulate matter 2.5 μm-induced inflammation in vitro and in vivo

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