Exposure to Estradiol before but Not during Acquisition of LiCl-Induced Conditioned Taste Avoidance Accelerates Extinction

Chambers, Kathleen C.; Hayes, UnJa L.

doi:10.1006/hbeh.2002.1774

Cited by 8 publications

(1 citation statement)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, previous studies using rats have reported that androgen treatments result in a slow extinction process [37][38][39], whereas we did not find any effects of androgen on acquisition of the extinction memory, the so-called extinction process, in the present study. This discrepancy may be attributable to the differences among protocols.…”

Section: Discussioncontrasting

confidence: 99%

The effect of androgen on the retention of extinction memory after conditioned taste aversion in mice

et al. 2013

View full text Add to dashboard Cite

Conditioned taste aversion (CTA) induced by the application of a novel taste such as sodium saccharin (Sac) as the conditioned stimulus (CS) and a malaise-inducing agent as the unconditioned stimulus (US), results in acquisition of CTA memory to Sac. In contrast, CTA is extinguished by repeated presentations of the CS without the US, resulting in acquisition of the extinction memory. We examined the effects of androgenic hormones on acquisition and retention of extinction memory in mice. We gonadectomized sexually immature mice and continuously administered androgens to these animals. After sexual maturation, the mice underwent a conditioning period followed by an extinction period. Retrieval tests revealed that the androgen-treated group showed significantly greater retention of extinction memory than the non-treated group 5 weeks later, whereas such significant difference was not observed in acquisition of extinction memory. These results demonstrate the enhancing effect of androgens on retention of extinction memory.

show abstract

Section: Discussioncontrasting

confidence: 99%

The effect of androgen on the retention of extinction memory after conditioned taste aversion in mice

et al. 2013

View full text Add to dashboard Cite

show abstract

Conditioned Taste Aversions

Chambers¹

2015

Handbook of Olfaction and Gustation

Self Cite

View full text Add to dashboard Cite

When one becomes ill after consuming a meal, there is a propensity to target a particular taste as the cause of the illness. The qualities of the taste most likely targeted include more novel, less preferred, and higher protein content. This association between a particular taste and illness is a form of learning that is termed conditioned taste aversion (CTA). A consequence of the learned association is that the taste will become aversive. When experiencing the taste again, individuals will show aversive reactions such as expressions of loathing, will experience mimicked illness sensations such as nausea, and subsequently, will avoid further exposure to the taste. The ability to acquire CTA occurs across species and across ages within a species. In the rat animal model, however, age differences exist in the capability of acquiring CTAs when increasingly longer intervals are imposed between consumption of a novel sweet solution and onset of illness. Pups have a decreased ability compared to young adults while aged rats have an increased ability. Evidence suggests that the failure of pups to acquire CTA at longer intervals is due to an immature retrieval mechanism and the facilitated ability of aged rats is due to a compromised clock mechanism that tracks the passage of time. Learned taste-illness association serves the critical function of informing individuals of the toxic nature of certain foods, thus preventing further illness and potentially death. Additionally, it contributes to the hypophagia observed during cancer chemotherapy and may contribute to the hypophagia found while suffering from bacterial infection, chronic medical conditions such as cancer, and restrictive food intake disorders such as anorexia nervosa.

show abstract

Estradiol enhances the acquisition of lithium chloride-induced conditioned taste aversion in castrated male rats

Lin

Tsai

Tai

et al. 2015

Sci Nat

View full text Add to dashboard Cite

The present study examined the effects of short-term treatment with ovarian hormones on the acquisition of conditioned taste aversion (CTA). Adult male rats were castrated and randomly divided into LiCl- and saline-treated groups. Nineteen days after castration, all of the animals were subjected to 23.5-h daily water deprivation for seven successive days (day 1 to day 7). On the conditioning day (day 8), the rats received either a 4 ml/kg of 0.15 M LiCl or the same dose of saline injection immediately after administration of a 2 % sucrose solution during the 30-min water session. Starting from day 6, rats in both groups received one of the following treatments: daily subcutaneous injection of (1) estradiol alone (30 μg/kg; estradiol benzoate (E) group), (2) estradiol plus progesterone (500 μg; E + progesterone (P) group), or (3) olive oil. From day 9 to day 11, all of the rats were given daily two-bottle preference tests during the 30-min fluid session. The estradiol and estradiol plus progesterone treatments in the LiCl groups resulted in significantly lower preference scores for the sucrose solution compared with the olive oil treatment groups, but no difference in preference score was seen between these two groups. These results indicate that both the estradiol and estradiol plus progesterone treatments in the LiCl groups enhanced the acquisition of CTA learning and suggest that estradiol affects the acquisition of CTA mediated by an activational effect in male rats, whereas progesterone treatment does not influence the effects of estradiol on the acquisition of CTA.

show abstract

Exposure to Estradiol before but Not during Acquisition of LiCl-Induced Conditioned Taste Avoidance Accelerates Extinction

Cited by 8 publications

References 63 publications

The effect of androgen on the retention of extinction memory after conditioned taste aversion in mice

The effect of androgen on the retention of extinction memory after conditioned taste aversion in mice

Conditioned Taste Aversions

Estradiol enhances the acquisition of lithium chloride-induced conditioned taste aversion in castrated male rats

Contact Info

Product

Resources

About