Exposure to heavy metals due to pesticide use by vineyard farmers

Rocha, Gustavo Henrique Oliveira da; Lini, Renata Sano; Barbosa, Fernando; Batista, Bruno Lemos; Souza, Vanessa Cristina de Oliveira; Nerilo, Samuel Botião; Bando, Érika; Mossini, Simone Aparecida Galerani; Nishiyama, Paula

doi:10.1007/s00420-014-1010-1

Cited by 32 publications

(16 citation statements)

References 26 publications

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“…An elevated exposure to copper may be mainly consequent to environmental pollution from the manufacture of wire, sheet metal, pipe and other metal products [ 2 ]. In addition, mining, waste dumps, combustion of fossil fuels, wood production and phosphate fertilizers release copper in the environment, thus contributing to the actual exposure in humans [ 2 - 4 ]. To date, mismanaged or high copper levels have been involved in the generation of oxidative stress [ 5 ] which plays an important role in cancer development [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Copper activates HIF-1α/GPER/VEGF signalling in cancer cells

et al. 2015

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Copper promotes tumor angiogenesis, nevertheless the mechanisms involved remain to be fully understood. We have recently demonstrated that the G-protein estrogen receptor (GPER) cooperates with hypoxia inducible factor-1α (HIF-1α) toward the regulation of the pro-angiogenic factor VEGF. Here, we show that copper sulfate (CuSO4) induces the expression of HIF-1α as well as GPER and VEGF in breast and hepatic cancer cells through the activation of the EGFR/ERK/c-fos transduction pathway. Worthy, the copper chelating agent TEPA and the ROS scavenger NAC prevented the aforementioned stimulatory effects. We also ascertained that HIF-1α and GPER are required for the transcriptional activation of VEGF induced by CuSO4. In addition, in human endothelial cells, the conditioned medium from breast cancer cells treated with CuSO4 promoted cell migration and tube formation through HIF-1α and GPER.The present results provide novel insights into the molecular mechanisms involved by copper in triggering angiogenesis and tumor progression. Our data broaden the therapeutic potential of copper chelating agents against tumor angiogenesis and progression.

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Section: Introductionmentioning

confidence: 99%

Copper activates HIF-1α/GPER/VEGF signalling in cancer cells

et al. 2015

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“…A maioria foi de estudos internacionais. 72 EUA, 2014 Coorte 32.345 esposas de aplicadores de agrotóxicos da coorte AHS com ≥35 anos Engel et al 73 EUA, 2017 Coorte 30.594 mulheres agricultoras participantes da coorte da AHS com ≥18 anos Lerro et al 74 EUA 21,28,40,[43][44][45]47,48,54,60,[62][63][64][67][68][69][70] , duração da exposição 16,17,19,[21][22][23]28,29,31,36,40,44,48,55,57,61,64,65,67,74 , frequência de uso/aplicação 16,36,45,60,74 , ocupação 16,30,39,46,47,…”

Section: Resultsunclassified

“…II) Condições subclínicas 20,29,[37][38][39][40][42][43][44][45]48,50,[52][53][54][55]62 : alterações bioquímicas, danos genéticos, estresse oxidativo; III) Sinais e sintomas de intoxicação aguda, queixas de saúde [60][61][62][63][64][65][66][67]69,70 .…”

Section: Resultsunclassified

“…Dentre os métodos de avaliação dos desfechos (Quadro 2), o uso de exames clínicos ou instrumentos já validados ocorreram em 21 estudos [16][17][18][20][21][22][23][25][26][27][28]30,32,33,36,64,68,[71][72][73][74] , a morbidade, sinais e sintomas autorreferidos em 14 estudos 24,33,37,39,41,60,62,63,[65][66][67][68][69][70] e o uso de biomarcadores de efeito em 23 estudos 20,27,29,30,37,39,40,[42][43][44][45]47,48,[50][51][52]…”

Section: Resultsunclassified

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Exposição a agrotóxicos e agravos à saúde em trabalhadores agrícolas: o que revela a literatura?

Nogueira

Szwarcwald

2020

Rev. bras. saúde ocup.

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Resumo Introdução: a relação entre agrotóxicos e agravos à saúde tem sido investigada em diferentes contextos. Objetivo: reunir evidência científica relevante sobre agravos à saúde associados à exposição ocupacional aos agrotóxicos. Métodos: revisão de literatura de estudos publicados entre 2000 e 2017, nas bases PubMed, Embase e LILACS. Estabeleceu-se como critérios de elegibilidade: a) estudos observacionais; b) população de trabalhadores agrícolas; c) exposição ocupacional; d) agravos à saúde definidos como desfecho; e) comparação estatística de expostos com não expostos; f) idioma inglês, português ou espanhol. Resultados: 59 publicações foram elegíveis - 33 estudos transversais, 22 de coorte e 4 caso-controle. Discussão: os estudos indicam que trabalhadores rurais apresentam maior risco para alguns agravos crônicos (câncer, doenças mentais, neurológicas, endócrinas, renais, auditivas, respiratórias e autoimunes), efeitos subclínicos (danos genéticos e alterações bioquímicas) e sinais e sintomas clínicos de intoxicação aguda. Também foram identificadas limitações dos estudos quanto à avaliação da exposição e do desfecho, delineamento e amostragem. Conclusão: as evidências sugerem a necessidade de se complementar a avaliação da saúde dos trabalhadores expostos aos agrotóxicos utilizando biomarcadores de efeito de genotoxicidade e citotoxicidade, a fim de promover e ampliar a vigilância da exposição e das intoxicações crônicas e suas prevenções.

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“…Previous occupational studies have found increased urinary levels of Mn (Canossa et al, 1993) and ethylenethiourea (ETU) (Runkle et al, 2013), the main metabolite of EBDCs, among farmworkers following mancozeb applications on agricultural fields. Another study found increased blood serum levels of Mn in farmworkers exposed to mancozeb compared to unexposed workers (Rocha et al, 2015). Environmental studies in communities living near agricultural fields have also found that closer residential proximity to agricultural use of EBDC fungicides was associated with increased Mn levels in pregnant women's hair (Mora et al, 2014), prenatal dentin from children's shed teeth (Gunier et al, 2013), and home dust samples (Gunier et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Manganese exposure and working memory-related brain activity in smallholder farmworkers in Costa Rica: Results from a pilot study

Palzes

Sagiv

Baker

et al. 2019

Environmental Research

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Main sources of manganese (Mn) in the general population are diet and drinking water. Mn is also found in ethylene bisdithiocarbamate (EBDC) fungicides used in agriculture or emitted into the air by ferromanganese plants and welding fumes, which can be additional environmental and occupational sources of exposure. High occupational Mn exposure has been linked with motor, behavioral, and cognitive impairment, but its effects on neural function remain poorly understood. We conducted a functional neuroimaging study in a sample of 48 farmworkers in Zarcero County, Costa Rica, an agricultural region where EBDC fungicides are sprayed. We measured Mn concentrations in farmworkers' toenails (n = 40 farmworkers) and hair (n = 33 farmworkers), and recorded brain activity in the dorsolateral prefrontal cortex during a letter-retrieval working memory task using functional near-infrared spectroscopy (fNIRS). We estimated exposureoutcome associations using multivariable linear regression models adjusted for age and education

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Exposure to heavy metals due to pesticide use by vineyard farmers

Abstract: It can be concluded that in the vineyard region assessed, farmers were more susceptible to heavy metal exposure due to pesticide use.

Cited by 32 publications

References 26 publications

Copper activates HIF-1α/GPER/VEGF signalling in cancer cells

Copper activates HIF-1α/GPER/VEGF signalling in cancer cells

Exposição a agrotóxicos e agravos à saúde em trabalhadores agrícolas: o que revela a literatura?

Manganese exposure and working memory-related brain activity in smallholder farmworkers in Costa Rica: Results from a pilot study

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