Exposure to lambda-cyhalothrin, a synthetic pyrethroid, increases reactive oxygen species production and induces genotoxicity in rat peripheral blood

Fetoui, Hamadi; Feki, Ameni; Salah, Ghada Ben; Kamoun, Hassen; Fakhfakh, Feiza; Gdoura, Radhouane

doi:10.1177/0748233713475516

Cited by 37 publications

(24 citation statements)

References 52 publications

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“…The biomarker malondialdehyde (MDA) is a common measure of oxidative stress in honey bees, other insects, and vertebrate systems21222324. MDA is the main organic compound produced from lipid peroxidation of polyunsaturated fatty acids in cellular membranes25.…”

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confidence: 99%

Migratory management and environmental conditions affect lifespan and oxidative stress in honey bees

Simone-Finstrom

Li-Byarlay

Huang

et al. 2016

Sci Rep

135

112

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Most pollination in large-scale agriculture is dependent on managed colonies of a single species, the honey bee Apis mellifera. More than 1 million hives are transported to California each year just to pollinate the almonds, and bees are trucked across the country for various cropping systems. Concerns have been raised about whether such “migratory management” causes bees undue stress; however to date there have been no longer-term studies rigorously addressing whether migratory management is detrimental to bee health. To address this issue, we conducted field experiments comparing bees from commercial and experimental migratory beekeeping operations to those from stationary colonies to quantify effects on lifespan, colony health and productivity, and levels of oxidative damage for individual bees. We detected a significant decrease in lifespan of migratory adult bees relative to stationary bees. We also found that migration affected oxidative stress levels in honey bees, but that food scarcity had an even larger impact; some detrimental effects of migration may be alleviated by a greater abundance of forage. In addition, rearing conditions affect levels of oxidative damage incurred as adults. This is the first comprehensive study on impacts of migratory management on the health and oxidative stress of honey bees.

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mentioning

confidence: 99%

Migratory management and environmental conditions affect lifespan and oxidative stress in honey bees

Simone-Finstrom

Li-Byarlay

Huang

et al. 2016

Sci Rep

135

112

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“…Although cyhalothrin has relatively low mammalian toxicity, there is still caution with regard to human exposure 8 11 . A number of studies have demonstrated that large dose exposures in mammals may cause significant toxicity and health effects, including neurotoxicity 12 , genotoxicity 13 14 , cytotoxicity 14 15 , and endocrine disruption which can damage mammalian reproduction 16 17 18 . Furthermore, chronic exposure to cyhalothrin even low level exposures may be associated with an elevated risk of mutagenicity 19 , carcinogenicity 20 , as well as childhood leukemia 21 .…”

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confidence: 99%

Pathway and kinetics of cyhalothrin biodegradation by Bacillus thuringiensis strain ZS-19

Chen

Deng

Chang

et al. 2015

Sci Rep

120

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Cyhalothrin is a common environmental pollutant which poses increased risks to non-target organisms including human beings. This study reported for the first time a newly isolated strain, Bacillus thuringiensis ZS-19 completely degraded cyhalothrin in minimal medium within 72 h. The bacterium transformed cyhalothrin by cleavage of both the ester linkage and diaryl bond to yield six intermediate products. Moreover, a novel degradation pathway of cyhalothrin in strain ZS-19 was proposed on the basis of the identified metabolites. In addition to degradation of cyhalothrin, this strain was found to be capable of degrading 3-phenoxybenzoic acid, a common metabolite of pyrethroids. Furthermore, strain ZS-19 participated in efficient degradation of a wide range of pyrethroids including cyhalothrin, fenpropathrinn, deltamethrin, beta-cypermethrin, cyfluthrin and bifenthrin. Taken together, our results provide insights into the mechanism of cyhalothrin degradation and also highlight the promising potentials of B.thuringiensis ZS-19 in bioremediation of pyrethroid-contaminated environment. This is the first report of (i) degradation of cyhalothrin and other pyrethroids by B.thuringiensis, (ii) identification of 3-phenoxyphenyl acetonitrile and N-(2-isoproxy-phenyl)-4-phenoxy-benzamide as the metabolites in the degradation pathway of pyrethroids, and (iii) a pathway of degradation of cyhalothrin by cleavage of both the ester linkage and diaryl bond in a microorganism.

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“…The oxidative damage could be resulted in cytotoxicity and immune alterations. Several previous reports recorded the generation of ROS, impairment of antioxidant enzyme activities and increased MDA and nitric oxide levels after exposure to LCT [21,23,[52][53][54][55][56]. It is possible that one scenario or more have contributed to the immunotoxic effects induced by LCT.…”

Section: Discussionmentioning

confidence: 96%

Evaluation of the Immunotoxic Effects of Sub-Chronic Doses of Lambda-Cyhalothrin in Murine Model

Ibrahim¹

2016

MOJI

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Lambda-cyhalothrin (LCT) is belonging to type II pyrethroid insecticides and utilized predominantly in Egypt to control a wide range of ectoparasites, including flies, mosquitoes, and cockroaches. Previous studies detected obvious genotoxicity and cytotoxicity of LCT. The current study was done to evaluate the immunological alterations on the levels of humoral and cellular immune responses after exposure to different doses (5, 1, 0.2mg/kg/day) of LCT in rat model. The current data displayed that LCT at dose 5mg/kg suppressed the total serum immunoglobulin concentration, hemagglutination titer, quantitative hemolysis of SRBCs (QHS), the phagocytic function of peritoneal macrophages and blood neutrophils. Moreover, 5mg/kg of LCT decreased the delayed-type hypersensitivity response, the proliferative response of the blood mononuclear cells, induced blood mononuclear cells death and reduced the percentage of CD4+ and CD8 + blood mononuclear cells without affecting CD4/CD8 ratio significantly. LCT at dose 1mg/kg inhibited the total serum immunoglobulin, QHS, the proliferative capacity of blood mononuclear cells, the phagocytic function of peritoneal macrophages and blood neutrophils. No significant differences were observed in all examined parameters in animals exposed to 0.2mg/kg of LCT.In conclusion, LCT exposure induced-immunotoxicity in a rat model at doses 5 and 1mg/kg, while 0.2mg/kg has no adverse effect on the examined immune parameters.Keywords: Lambda-cyhalothrin Evaluation of the Immunotoxic Effects of Sub-Chronic Doses of Lambda-Cyhalothrin in Murine Model 2/8Copyright: ©2016 Ibrahim dose-dependent immunological alterations resulted by LCT. In the current study, doses of 5, 1 and 0.2 mg/kg of LCT were orally administrated to male rats. The oral LD50 value of LCT was estimated to be 79 mg/kg in male rats [22]. The selected doses of LCT were at least 15 times smaller than those recorded for LD50 in male rats and therefore adequate for the search for an immunological no-observed-adverse-effect level (NOAEL). Moreover, recent study reported that 0.6 mg/kg of LCT elicited significant alterations in the level of malondialdehyde (MDA), nitric oxide, pro-inflammatory cytokines and up-regulated NF-κB/ p65 in a rat model [23]. Hence, 0.2 mg/kg of LCT, which considered three times lower than the dose that used in the previous study, could be especially convenient for the immunological NOAEL. Keeping this in view, the main goal of this study was to evaluate the immunotoxic effects of the selected sub-chronic doses of LCT in a rat model. The current study was extended to examine the suitable dose for the assessment of the NOAEL among the selected doses. Material and methods Chemicals AnimalsMale albino Wistar rats (weighting approximately 210-250 g) were obtained from the Egyptian Organization for Serology and Vaccination, Ministry of Health, Cairo, Egypt. For the preparation of complement which utilized in quantitative hemolysis of sheep red blood cells (SRBCs) assay, female guinea pigs (240g) were used. Al...

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Exposure to lambda-cyhalothrin, a synthetic pyrethroid, increases reactive oxygen species production and induces genotoxicity in rat peripheral blood

Cited by 37 publications

References 52 publications

Migratory management and environmental conditions affect lifespan and oxidative stress in honey bees

Migratory management and environmental conditions affect lifespan and oxidative stress in honey bees

Pathway and kinetics of cyhalothrin biodegradation by Bacillus thuringiensis strain ZS-19

Evaluation of the Immunotoxic Effects of Sub-Chronic Doses of Lambda-Cyhalothrin in Murine Model

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