Exposure to phthalates in couples undergoing in vitro fertilization treatment and its association with oxidative stress and DNA damage

Al‐Saleh, Iman; Coşkun, Serdar; Al-Doush, Inaam; Al-Rajudi, Tahreer; Al-Rouqi, Reem; Abduljabbar, Mai; Al-Hassan, Saad

doi:10.1016/j.envres.2018.11.018

Cited by 29 publications

(10 citation statements)

References 120 publications

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“…Many studies showed that pharmaceuticals could be a source of phthalate exposure [39,40]. When we analysed the specific type of pharmaceuticals-hormonal therapy-we found surprisingly higher levels of MnBP, OH-MEHP, and oxo-MEHP in women who did not use hormonal therapy, which is in disagreement with the studies of Al Saleh et al [41,42], who observed increased phthalate metabolite concentrations in probands undergoing in vitro fertilisation [41], and women with contraceptive-use history [42]. The possible explanation for this inconsistency may be that in our study, we evaluated the use of hormonal therapy in general, regardless of its division into contraceptives, in vitro-fertilisation pharmaceuticals, and other groups of treatment, leading to possible different results.…”

Section: Analysis Of Maternal Baseline Characteristics In Association...contrasting

confidence: 95%

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

et al. 2022

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Adverse birth outcomes present risk factors resulting in neonatal morbidity and mortality. Sufficient maternal hormonal concentrations are crucial for normal foetal development. Previous studies have shown a relationship between phthalate exposure and maternal hormonal levels during pregnancy. This study aims to investigate if neonatal anthropometric parameters are associated with maternal endocrine parameters during the ≤15th week of gestation and the third trimester of pregnancy concerning phthalate exposure in pregnant women from Nitra, Slovakia. We used high-performance liquid chromatography, tandem mass spectrometry (HPLC-MS/MS), and electro-chemiluminescence immunoassay to quantify urinary concentrations of phthalates and serum concentrations of hormones and sex hormone-binding globulin (SHBG), respectively. We observed a mostly positive correlation between neonatal anthropometric parameters (gestational age, birth length, birth weight, head circumference) and maternal concentration of phthalate metabolites (p ≤ 0.05). The hierarchical multivariate regression results showed a statistically significant association between Apgar score at 5 min after delivery, gestational age, birth weight, head circumference, and maternal endocrine parameters during pregnancy (p ≤ 0.05), adjusted to phthalate metabolites. To the best of our knowledge, our study is the first to indicate that prenatal exposure to phthalates may also affect birth outcomes through interaction with the maternal endocrine system.

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Section: Analysis Of Maternal Baseline Characteristics In Association...contrasting

confidence: 95%

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

et al. 2022

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“…In addition, these biomarkers were related to the increased odds of spontaneous preterm delivery (adjusted OR = 6.25; 95% CI = 2.86–13.7), reaching the strongest correlation in the last trimester. Moreover, prospective studies have shown that the effects of phthalate exposure on fertilization rates may also be mediated by oxidative stress . Toxicological studies have also demonstrated that DINP induces apoptosis and autophagy in mouse ovarian granulosa cells via oxidative stress .…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, prospective studies have shown that the effects of phthalate exposure on fertilization rates may also be mediated by oxidative stress. 216 Toxicological studies have also demonstrated that DINP induces apoptosis and autophagy in mouse ovarian granulosa cells via oxidative stress. 217 Moreover, most of the current studies on the exploration of oxidative stress mechanisms are limited to single-compound exposures, whereas most phthalates are exposed as mixtures; co-exposure mixing may have a strong impact.…”

Section: Effects On Pregnancy and Offspring Developmentmentioning

confidence: 99%

Cumulative Exposure to Phthalates and Their Alternatives and Associated Female Reproductive Health: Body Burdens, Adverse Outcomes, and Underlying Mechanisms

Weng

Zhu

Liao

et al. 2023

Environ. Sci. Technol.

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The global birth rate has recently shown a decreasing trend, and exposure to environmental pollutants has been identified as a potential factor affecting female reproductive health. Phthalates have been widely used as plasticizers in plastic containers, children's toys, and medical devices, and their ubiquitous presence and endocrine-disrupting potential have already raised particular concerns. Phthalate exposure has been linked to various adverse health outcomes, including reproductive diseases. Given that many phthalates are gradually being banned, a growing number of phthalate alternatives are becoming popular, such as di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH), di(2-ethylhexyl) adipate (DEHA), and di(2-ethylhexyl) terephthalate (DEHTP), and they are beginning to have a wide range of environmental effects. Studies have shown that many phthalate alternatives may disrupt female reproductive function by altering the estrous cycle, causing ovarian follicular atresia, and prolonging the gestational cycle, which raises growing concerns about their potential health risks. Herein, we summarize the effects of phthalates and their common alternatives in different female models, the exposure levels that influence the reproductive system, and the effects on female reproductive impairment, adverse pregnancy outcomes, and offspring development. Additionally, we scrutinize the effects of phthalates and their alternatives on hormone signaling, oxidative stress, and intracellular signaling to explore the underlying mechanisms of action on female reproductive health, because these chemicals may affect reproductive tissues directly or indirectly through endocrine disruption. Given the declining global trends of female reproductive capacity and the potential ability of phthalates and their alternatives to negatively impact female reproductive health, a more comprehensive study is needed to understand their effects on the human body and their underlying mechanisms. These findings may have an important role in improving female reproductive health and in turn decreasing the number of complications during pregnancy.

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“…Oxidative stress reaction were determined by testing ROS and GSH generation , both of which can serve as early alarming indicators of exposure to bioactive pollutants . These assays have been used to identify the harmful effects of pollutants ) such as pesticides , phthalates (Al-Saleh et al, 2019), DBPs , and PAHs and to evaluate water quality (Peluso et al, 2021). Low level contaminants present in the UOCEs at low dose levels could lead to significant changes.…”

Section: Oxidative Stress Induced By Uocesmentioning

confidence: 99%

Single enrichment systems possibly underestimate both exposures and biological effects of organic pollutants from drinking water

et al. 2022

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Exposure to phthalates in couples undergoing in vitro fertilization treatment and its association with oxidative stress and DNA damage

Cited by 29 publications

References 120 publications

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

Cumulative Exposure to Phthalates and Their Alternatives and Associated Female Reproductive Health: Body Burdens, Adverse Outcomes, and Underlying Mechanisms

Single enrichment systems possibly underestimate both exposures and biological effects of organic pollutants from drinking water

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