Exposure to phthalates is associated with acute urticaria in children

Yon, Dong Keon; Cho, Young Sun; Ha, Eun Kyo; Jee, Hye Mi; Song, Jin; Jung, Young-Ho; Lee, Kyung Suk; Sheen, Youn Ho; Han, Man Yong

doi:10.1111/pai.12932

Cited by 7 publications

(8 citation statements)

References 13 publications

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“…Moreover, rapid economic development with Westernized lifestyles and urbanization is associated with an increasing trend in allergic rhinitis [ 24 ]. Further more, a previous study reported that various outdoor environmen tal factors (i.e., air pollution, weather condition, aero allergen, and respiratory virus infection) and endocrine disrup tion chemicals (i.e., phthalate, paraben, and triclosan) may have affected the prevalence of allergic rhinitis [ 13 , 25 , 26 ]. The signifi cant increase in allergic rhinitis prevalence requires the establish ment of a global strategy of effective prevention and treatment [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Ten-Year trends and prevalence of asthma, allergic rhinitis, and atopic dermatitis among the Korean population, 2008–2017

2020

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Background: Major questions remain regarding the agestratified trends of allergic diseases and asthma in Korea.Purpose: To identify the estimated recent prevalence and 10- year trends in asthma, allergic rhinitis, and atopic dermatitis among the Korean population from 2008 to 2017.Methods: This nationwide cross-sectional survey (Korean National Health and Nutrition Examination Survey) over 10 years (2008–2017) examined representative samples of the Korean population (n=85,006) including 2,131 infants, 4,352 preschool children, 12,919 school-age children, 44,200 adults, and 21,404 elderly adults.Results: In the 2016 to 2017 population, the estimated prevalence of asthma was 0.9% in infants, 2.3% in preschool children, 4.1% in school-age children, 2.3% in adults, and 4.1% in the elderly. The estimated prevalence of allergic rhinitis was 9.0%, 20.2%, 27.6%, 17.1%, and 6.9%, respectively. The estimated prevalence of atopic dermatitis was 5.9%, 11.3%, 14.6%, 3.9%, and 1.6%, respectively. Ten-year trends revealed a significant decrease in asthma prevalence in infants, preschool children, and the elderly. and in atopic dermatitis prevalence in infants and preschool children (<i>P</i><0.05 for all trends). Furthermore, 10-year trends demonstrated a significant increase in allergic rhinitis prevalence in school-age children, adults, and the elderly, and in atopic dermatitis prevalence in school-age children and the elderly (<i>P</i><0.05 for all trends).Conclusion: These results improve our understanding of the age-stratified epidemiology of allergic diseases in Korea and suggest the need for the development of tailored and precise strategies to prevent allergic diseases in different age groups.

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Section: Discussionmentioning

confidence: 99%

Ten-Year trends and prevalence of asthma, allergic rhinitis, and atopic dermatitis among the Korean population, 2008–2017

2020

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“…We believe that urinary concentration of Pb and TCs are reliable biomarkers for evaluating these exposures. It is well-known that another chemicals such as phthalate [22], metabolites of diethylhexyl [23] and bisphenol A [24] increased the risk of allergy. We should pay more attention to another chemicals.…”

Section: Discussionmentioning

confidence: 99%

Exposure to paraben and triclosan and allergic diseases in Tokyo: A pilot cross-sectional study

Mitsui-Iwama

Yamamoto‐Hanada

Fukutomi

et al. 2019

Asia Pacific Allergy

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BackgroundPrevious studies have reported that exposure to paraben (Pb) and triclosan (TCS) is associated with allergies. However, Pb and TCS exposure in the Japanese population is not fully understood.ObjectivesThe present study was aimed to examine such exposure among Japanese individuals with allergic diseases.MethodsThis cross-sectional study included the International Study of Asthma and Allergies in Childhood questionnaire survey to evaluate allergic outcomes and the collection of urine samples to examine Pb and TCS exposure.ResultsPb containing daily commodities was used in 84.8% children. Pb use was positively associated with current atopic dermatitis (adjusted odds ratio, 4.61; 95% confidence interval, 1.23–17.3). Urinary Pb concentrations were increased significantly in those with current atopic dermatitis (AD) (median, 4.58 vs. 0; p < 0.0001), and showed an increased tendency in those with current wheeze (median, 3.45 vs. 1.81; p = 0.0535) in participants ≤15 years old. Urinary TCS concentration was under the limit of detection in all children.ConclusionUrinary levels of Pb were associated with current AD in children. We should pay more attention about Pb and TCS.

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“…Because of the widespread use of phthalates and the identification of possible adverse health effects, governments have restricted exposure levels and increased monitoring 2 . Phthalates may have harmful effects on the reproductive system by functioning as endocrine disruptors and are associated with allergic diseases such as eczema, urticaria, asthma, and rhinitis as well as airway inflammation and reduced lung function 2‐5 . The route of exposure is usually via ingestion, inhalation, intravenous injection, and skin absorption 1 .…”

Section: Rrs5 (Hpa/l/s) Ax (Hpa/l/s) Vol 0‐5 CM (Cm3) Vol 2‐5 Cm (Cm3mentioning

confidence: 99%

“…Particularly, children are more likely to have exposure to phthalates than adults through ingestion of dietary sources or inhalation of dust from phthalate containing products. Recent studies demonstrated that exposure to phthalates influences T helper 2 (Th2) cells, cytokines, and fractional exhaled nitric oxide (FeNO), a marker of type 2 airway inflammation 1‐6 . However, the association of phthalates with functional parameters of allergic diseases, such as upper nasal airway patency or lower small airway dysfunction, is unknown.…”

Section: Rrs5 (Hpa/l/s) Ax (Hpa/l/s) Vol 0‐5 CM (Cm3) Vol 2‐5 Cm (Cm3mentioning

confidence: 99%

“…This cross‐sectional study examined 149 randomly selected first‐grade students at 11 elementary schools during from January to December of 2016 in Seongnam City, Korea. The study subjects were enrolled and asked to perform the tests, as described in a previous study 3 . The study protocol was approved by the Institutional Review Board of CHA University (2016‐04‐031).…”

Section: Rrs5 (Hpa/l/s) Ax (Hpa/l/s) Vol 0‐5 CM (Cm3) Vol 2‐5 Cm (Cm3mentioning

confidence: 99%

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Association of phthalates with nasal patency and small airway dysfunction in first‐grade elementary school children

Kim

Yon

Jee

et al. 2020

Allergy

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Exposure to phthalates is associated with acute urticaria in children

Cited by 7 publications

References 13 publications

Ten-Year trends and prevalence of asthma, allergic rhinitis, and atopic dermatitis among the Korean population, 2008–2017

Ten-Year trends and prevalence of asthma, allergic rhinitis, and atopic dermatitis among the Korean population, 2008–2017

Exposure to paraben and triclosan and allergic diseases in Tokyo: A pilot cross-sectional study

Association of phthalates with nasal patency and small airway dysfunction in first‐grade elementary school children

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