Exposure to polybrominated diphenyl ethers and female reproductive function: A study in the production area of Shandong, China

Gao, Yu; Chen, Limei; Wang, Cai‐Feng; Zhou, Yijun; Wang, Yiwen; Zhang, Yan; Hu, Yi; Ji, Lin; Shi, Rong; Cui, Chong; Ding, Guodong; Jin, Jun; Tian, Ying

doi:10.1016/j.scitotenv.2016.07.181

Cited by 40 publications

(26 citation statements)

References 49 publications

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“…This is the first study to show that elevated preconception serum PBDEs may be associated with increased hazard of incident pregnancy loss, especially giving weight to lower brominated PBDE congeners. However, a previous study in China reported an increased odds of a threatened abortion in relation to BDE-28 (Odds Ratio (OR): 1.03; 95% CI: 0.96–1.10), and statistically significant associations with BDE-85 (OR: 1.30; 95% CI: 1.03–1.62), −153 (OR: 1.04; 95% CI: 1.01–1.08), and −183 (OR: 1.03; 95% CI: 1.01–1.06) (Gao et al, 2016). Differences between study results could be due to heterogeneity in study designs (i.e., selection criteria, timing and measurement of exposures, and model specification and techniques) and definition of pregnancy loss.…”

Section: Discussionmentioning

confidence: 99%

“…PBDEs are known endocrine disruptors and neurotoxins, primarily targeting the thyroid system due to their structural similarities to endogenous thyroid hormones (Siddiqi et al, 2003; Herbstman 2014). Previous studies have reported increased risk of adverse female reproductive outcomes and fetal development in relation to increased PBDE concentrations, as suggested by their associations with altered hormone milieu (Gao et al, 2016; Vuong et al, 2015), failed embryo implantation (Johnson et al, 2012), a longer time-to-pregnancy (Buck Louis et al, 2013; Gao et al, 2016), pregnancy complications (Smarr et al, 2016), and diminished birth size (Robledo et al, 2015). However, most previous research focusing on reproductive outcomes has relied upon cohorts that enrolled pregnant women (Harley et al, 2010; Stapleton et al, 2011; Vuong et al, 2015) and often later in pregnancy or the peak window for loss.…”

Section: Introductionmentioning

confidence: 99%

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Polybrominated diphenyl ethers and incident pregnancy loss: The LIFE Study

Choi

Wang

Sundaram

et al. 2019

Environmental Research

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Background Polybrominated diphenyl ethers (PBDEs) have not been studied in relation to incident pregnancy loss in human populations, despite their ubiquitous exposure and purported reproductive toxicity. Objectives To investigate the association between preconception serum PBDE concentrations and incident pregnancy loss. Methods A preconception cohort of 501 couples was followed while trying to become pregnant, and for whom serum concentrations of 10 PBDE congeners were measured using gas chromatography-high resolution mass spectrometry. Pregnancy was prospectively identified as a positive home pregnancy test on the day of expected menstruation. Incident pregnancy loss was defined for 344 singleton pregnancies as a conversion to a negative home pregnancy test, menses, or clinical diagnosis depending upon gestational age. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for individual and summed PBDEs and incident pregnancy loss, adjusting for relevant covariates and male partners’ information. In sensitivity analyses, inverse probability weighting was used to account for couples not becoming pregnant and, thereby, not at risk for loss. Results The incidence of prospectively observed pregnancy loss was 28%, and the serum concentrations of PBDE congeners in females were consistently associated with a higher hazard of incident pregnancy loss. Specifically, statistically significant hazard ratios (HRs) for incident pregnancy loss were observed for lower brominated PBDE congeners: 17 (HR 1.23; CI: 1.07–1.42), 28 (HR 1.25; CI: 1.03–1.52), 66 (HR 1.23; CI: 1.07–1.42), and homolog triBDE (HR: 1.25; CI: 1.05–1.49). Findings were robust to various model specifications explored in sensitivity analyses. Conclusions Maternal preconception serum concentrations of specific PBDE congeners may increase the hazard of incident pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polybrominated diphenyl ethers and incident pregnancy loss: The LIFE Study

Choi

Wang

Sundaram

et al. 2019

Environmental Research

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“…Among these, one study examined both PBDEs and HBCD (Den Hond et al, 2015), one study examined both TTP and other female reproductive function (Gao et al, 2016). As shown in Table 2, retrospective and prospective cohort studies were the most common study design (Harley et al, 2010;Chevrier et al, 2013;Buck Louis et al, 2013;Gao et al, 2016). There was one case-control study (Den Hond et al, 2015).…”

Section: Brominated Flame Retardantsmentioning

confidence: 99%

“…There was one case-control study (Den Hond et al, 2015). Studies by Gao et al (2016), andDen Hond et al (2015) were included in both Tables 2 and 3 as they both investigated BFRs and phthalates. All studies included in this review analysed BFR chemical concentrations in blood (n=5).…”

Section: Brominated Flame Retardantsmentioning

confidence: 99%

“…All studies included in this review analysed BFR chemical concentrations in blood (n=5). Of these, three epidemiological studies in females for TTP or fecundability were extracted (Harley et al, 2010;Chevier et al, 2013;Gao et al, 2016). One epidemiological study examined both PBDEs and HBCD and subfertility (Den Hond et al, 2015).…”

Section: Brominated Flame Retardantsmentioning

confidence: 99%

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A systematic review: Impact of endocrine disrupting chemicals exposure on fecundity as measured by time to pregnancy

Kim

Pacella

Harden

et al. 2019

Environmental Research

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Infertility, fecundity, time to pregnancy, EDCs, brominated flame retardants, POPs, hexabromocyclododecane, human, polybrominated diphenyl ethers, phthalates, and organophosphate flame retardants EDCs (environmental disrupting chemicals), BFR (brominated flame retardant), HBCD (hexabromocyclododecane), PBDE (polybrominated diphenyl ether), TBBPA (tetrabromobiphenol A), POPs (persistent organic pollutants), OPFRs (Organophosphates Flame Retardants), phthalates: MnBP (Mono-n-butyl phthalate), MBzP (Mono-ethyl phthalate), MMP (Mono-methyl phthalate), MEP (Mono-ethyl phthalate), MCHP (Mono-cyclo-hexyl phthalate), MiNP (Mono-isononyl phthalate), MCP (Mono-(3-carboxypropyl) phthalate), MEHP (Mono-(2ethylhexyl) phthalate), MEOHP (Mono-(2-ethyl-5-oxo-hexyl) phthalate), IVF (in vitro fertilization), DE (Deiphenyl Ethers), PRISMA (the Preferred Reporting Items for Systematic

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Exposure to Synthetic Endocrine-Disrupting Chemicals in Relation to Maternal and Fetal Sex Steroid Hormones: A Scoping Review

Hansel,

Rosenberg,

Kinkade

et al. 2024

Curr Envir Health Rpt

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Purpose of Review Many synthetic endocrine-disrupting chemicals (EDCs) are ubiquitous in the environment and highly detected among pregnant people. These chemicals may disrupt maternal and/or fetal sex steroid hormones, which are critical to pregnancy maintenance and fetal development. Here, we review the epidemiological literature examining prenatal exposure to common synthetic EDCs in relation to maternal and fetal sex steroid hormones. Recent Findings We performed a literature search using PubMed, SCOPUS, and Embase, ultimately identifying 29 articles for full review. Phenols, parabens, and persistent organic pollutants generally showed inverse associations with androgens, estrogens, and progesterone. Phthalates and per-and polyfluoroalkyl substances tended to be inversely associated with progesterone, while evidence regarding androgens and estrogens was mixed. Inconsistent, but noteworthy, differences by fetal sex and timing of exposure/outcome were observed. Summary Overall, the literature suggests EDCs may disrupt maternal and fetal sex steroid activity, though findings are mixed. Given the pervasive, high-volume production of these synthetic chemicals and the critical functions sex steroid hormones play during gestation, additional research is warranted.

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Exposure to polybrominated diphenyl ethers and female reproductive function: A study in the production area of Shandong, China

Cited by 40 publications

References 49 publications

Polybrominated diphenyl ethers and incident pregnancy loss: The LIFE Study

Polybrominated diphenyl ethers and incident pregnancy loss: The LIFE Study

A systematic review: Impact of endocrine disrupting chemicals exposure on fecundity as measured by time to pregnancy

Exposure to Synthetic Endocrine-Disrupting Chemicals in Relation to Maternal and Fetal Sex Steroid Hormones: A Scoping Review

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