Exposure to Radiation During Work Shifts and Working at Night Act as Occupational Stressors Alter Redox and Inflammatory Markers

El-Benhawy, Sanaa A.; El-Tahan, Rasha A.; Nakhla, Sameh

doi:10.1016/j.arcmed.2020.10.001

Cited by 17 publications

(8 citation statements)

References 35 publications

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“…In the current study, the proinflammatory cytokine TNF-α and the anti-inflammatory cytokine IL-10 were also examined, and it was found that the TNF-α level was higher and the IL-10 level was lower in people working in the radiation field compared to those that were not exposed to IR in the work environment. In a study conducted with female nurses, El-Benhawy et al (2020) found that TNF-α and other inflammation indicators (C-reactive protein and interferon gamma) were higher in radiation workers compared to the control group. Aneva et al (2019) reported higher TNF-α levels and lower IL-10 levels in nuclear power plant workers who were occupationally exposed to low-dose gamma radiation than those who did not work in the radiation unit.…”

Section: Discussionmentioning

confidence: 97%

Effects of Occupational Exposure to Ionizing Radiation on Oxidative Stress and Inflammatory Markers in Healthcare Workers of a University Hospital in Konya, Turkey

ARDIÇ

Şahin

Uyar

et al. 2022

Journal of Cellular Neuroscience and Oxidative Stress

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Journal of Cellular Neuroscience and Oxidative Stress is an online journal that publishes original research articles, reviews and short reviews on the molecular basis of biophysical, physiological and pharmacological processes that regulate cellular function, and the control or alteration of these processes by the action of receptors, neurotransmitters, second messengers, cation, anions, drugs or disease.Areas of particular interest are four topics. They are;A-Ion Channels (Na + -K + Channels, Clchannels, Ca 2+ channels, ADP-Ribose and metabolism of NAD + , Patch-Clamp applications) B-Oxidative Stress (Antioxidant vitamins, antioxidant enzymes, metabolism of nitric oxide, oxidative stress, biophysics, biochemistry and physiology of free oxygen radicals) C-Interaction Between Oxidative Stress and Ion Channels in Neuroscience (Effects of the oxidative stress on the activation of the voltage sensitive cation channels, effect of ADP-Ribose and NAD + on activation of the cation channels which are sensitive to voltage, effect of the oxidative stress on activation of the TRP channels in neurodegenerative diseases such Parkinson's and Alzheimer's diseases) D-Gene and Oxidative Stress (Gene abnormalities. Interaction between gene and free radicals. Gene anomalies and iron. Role of radiation and cancer on gene polymorphism)

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Section: Discussionmentioning

confidence: 97%

Effects of Occupational Exposure to Ionizing Radiation on Oxidative Stress and Inflammatory Markers in Healthcare Workers of a University Hospital in Konya, Turkey

ARDIÇ

Şahin

Uyar

et al. 2022

Journal of Cellular Neuroscience and Oxidative Stress

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“…The indirect interaction of IR leads to hydrolysis of water molecules resulting in hydrogen and a hydroxyl free radical molecule [19]. Moreover, occupational exposure to IR increases the secretion of pro-inflammatory cytokines [20,21].…”

Section: Discussionmentioning

confidence: 99%

Impact of occupational exposure to low dose ionizing radiation versus high dose exposure during radiotherapy on met Hb levels

El-Benhawy

Roba

Fahmy

et al. 2022

Arab Journal of Nuclear Sciences and Applications

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Background: Ionizing radiation affects human health as it breaks the chemical bonds of the molecules and damages DNA through the manufacturing of free radicals, resulting in apoptosis of proliferative cells/ damage to erythrocytes which may influence the quality of RBC concentrates. The aim of the present investigation is to evaluate the effect of occupational exposure to low dose ionizing radiation versus high dose exposure during radiotherapy on met Hb levels. 150 individuals were included divided into two groups; group I, includes 50 radiation workers (RWs) compared to 25 healthy volunteers' as control group for radiation workers who never exposed to radiation in their work. Group II includes 50 breast cancer patients who were treated with post-operative radiotherapy compared to 25 matched age and sex healthy female volunteers' as control group who had never worked in radiation-related jobs. Methemoglobin was assayed by ELISA. Significant decrease in MCV and serum ferritin was observed among RWs in comparison to the control group. Methemoglobin levels and Reticulocyte % were significantly higher in RWs in comparison to the BCPs. Mean values of WBCs, HB and RBCs were significantly lower in BCPs when compared to RWs, while there was insignificant difference in the mean values of Ht, MCV, MCH and RDW. It is concluded that serum methemoglobin levels and Reticulocyte % can be used as biological markers for early assessment of the absorbed dose in radiation workers.

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“…However, it is recently reported (by analyzing blood samples from 150 nurses) that ionizing radiation exposure during shift work and working at night elevates levels of circulating redox and inflammatory cytokines, which are known to induce cell mutation and cancer development. 38 …”

Section: Discussionmentioning

confidence: 99%

Assessment of risks for breast cancer in a flight attendant exposed to night shift work and cosmic ionizing radiation: a case report

Park

Seo

et al. 2022

Ann Occup Environ Med

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Background Some epidemiological studies have estimated exposure among flight attendants with and without breast cancer. However, it is difficult to find a quantitative evaluation of occupational exposure factors related to cancer development individually in the case of breast cancer in flight attendants. That is, most, if not all, epidemiological studies of breast cancer in flight attendants with quantitative exposure estimates have estimated exposure in the absence of individual flight history data. Case presentation A 41-year-old woman visited the hospital due to a left breast mass after a regular check-up. Breast cancer was suspected on ultrasonography. Following core biopsy, she underwent various imaging modalities. She was diagnosed invasive ductal carcinoma of no special type (estrogen receptor positive in 90%, progesterone receptor positive in 3%, human epidermal growth factor receptor 2/neu equivocal) with histologic grade 3 and nuclear grade 3 in the left breast. Neoadjuvant chemotherapy was administered to reduce the tumor size before surgery. However, due to serious chemotherapy side effects, the patient opted for alternative and integrative therapies. She joined the airline in January, 1996. Out of all flights, international flights and night flights accounted for 94.9% and 26.2, respectively. Night flights were conducted at least four times per month. Moreover, based on the virtual computer program CARI-6M, the estimated dose of cosmic radiation exposure was 78.81 mSv. There were no other personal triggers or family history of breast cancer. Conclusions This case report shows that the potentially causal relationship between occupational harmful factors and the incidence of breast cancer may become more pronounced when night shift workers who work continuously are exposed to cosmic ionizing radiation. Therefore, close attention and efforts are needed to adjust night shift work schedules and regulate cosmic ionizing radiation exposure.

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Exposure to Radiation During Work Shifts and Working at Night Act as Occupational Stressors Alter Redox and Inflammatory Markers

Cited by 17 publications

References 35 publications

Effects of Occupational Exposure to Ionizing Radiation on Oxidative Stress and Inflammatory Markers in Healthcare Workers of a University Hospital in Konya, Turkey

Effects of Occupational Exposure to Ionizing Radiation on Oxidative Stress and Inflammatory Markers in Healthcare Workers of a University Hospital in Konya, Turkey

Impact of occupational exposure to low dose ionizing radiation versus high dose exposure during radiotherapy on met Hb levels

Assessment of risks for breast cancer in a flight attendant exposed to night shift work and cosmic ionizing radiation: a case report

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