Exposure to sub-lethal dose of a combination insecticide during early embryogenesis influences the normal patterning of mesoderm resulting in incomplete closure of ventral body wall of chicks of domestic hen

Sharma, Shashikant; Uggini, Gowri K.; Patel, Venus; Desai, Isha; Balakrishnan, Suresh

doi:10.1016/j.toxrep.2018.02.005

Cited by 7 publications

(2 citation statements)

References 45 publications

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“…[40,41,31]. Increased percent mortality was observed in dose dependent manner in domestic hen exposed to combination of pesticides (chlorpyrifos + cypermethrin) [42].…”

Section: Resultsmentioning

confidence: 99%

Assessment of acute toxicity and biochemical responses to chlorpyrifos, cypermethrin and their combination exposed earthworm, Eudrilus eugeniae

2019

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“…[40,41,31]. Increased percent mortality was observed in dose dependent manner in domestic hen exposed to combination of pesticides (chlorpyrifos + cypermethrin) [42].…”

Section: Resultsmentioning

confidence: 99%

Assessment of acute toxicity and biochemical responses to chlorpyrifos, cypermethrin and their combination exposed earthworm, Eudrilus eugeniae

2019

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“…Agricultural soils and even public playgrounds are frequently contaminated by pesticide mixtures [ 38 ]. Pesticides can have greater toxic effects in mixtures than when they are tested individually in earthworms [ 39 ] and other animal species such as chicks [ 40 ], salmon [ 41 ] or on mammalian bone marrow erythrocytes in CD-1 mice [ 42 ]. Recent scientific studies have highlighted the need to test real-life exposure scenarios [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

Impacts of a glyphosate-based herbicide on the gut microbiome of three earthworm species (Alma millsoni, Eudrilus eugeniae and Libyodrilus violaceus): A pilot study

et al. 2021

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Embryonic Flubendiamide Exposure Alters Expression of OTX2 and Other Early Regulators in Domestic Chick Leading to Congenital Eye Defects

Danes,

Parmar,

Vaishnav

et al. 2024

J Biochem & Molecular Tox

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Flubendiamide, a phthalic acid diamide insecticide, has been implicated in potential teratogenic effects on non‐target organisms, especially during embryonic development. This study examines the impact of flubendiamide on eye development in chick embryos, a well‐established model for vertebrate development. Exposure to 0.5 µg/µL of flubendiamide significantly impaired early ocular morphogenesis, resulting in severe defects such as underdeveloped optic cups and the absence of lens and corneal structures. Histopathological analysis demonstrated disrupted optic cup differentiation, while in silico docking studies revealed strong interactions between flubendiamide and key oculogenic proteins, including OTX2, PAX6, and SOX2. These interactions were associated with altered expression patterns of these critical regulators, alongside overexpression of SHH and downregulation of BMP4, BMP7, and FGF8, which are essential for optic vesicle formation and lens differentiation. Additionally, increased CASPASE‐3 expression indicated enhanced apoptosis, contributing to the observed ocular anomalies. These findings suggest that flubendiamide disrupts key signaling pathways necessary for proper eye development, potentially leading to congenital eye defects. The study highlights the need for a thorough evaluation of the molecular mechanisms driving flubendiamide‐induced teratogenicity to ensure safer pesticide use and protect environmental and human health.

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Exposure to sub-lethal dose of a combination insecticide during early embryogenesis influences the normal patterning of mesoderm resulting in incomplete closure of ventral body wall of chicks of domestic hen

Abstract: Graphical abstract

Cited by 7 publications

References 45 publications

Assessment of acute toxicity and biochemical responses to chlorpyrifos, cypermethrin and their combination exposed earthworm, Eudrilus eugeniae

Assessment of acute toxicity and biochemical responses to chlorpyrifos, cypermethrin and their combination exposed earthworm, Eudrilus eugeniae

Impacts of a glyphosate-based herbicide on the gut microbiome of three earthworm species (Alma millsoni, Eudrilus eugeniae and Libyodrilus violaceus): A pilot study

Embryonic Flubendiamide Exposure Alters Expression of OTX2 and Other Early Regulators in Domestic Chick Leading to Congenital Eye Defects

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