Exposure to volatile organic compounds and kidney dysfunction in thin film transistor liquid crystal display (TFT-LCD) workers

Chang, Ta-Yuan; Huang, Kuei-Hung; Liu, Chiu-Shong; Shie, Ruei-Hao; Chao, Keh-Ping; Hsu, Wei‐Li; Bao, Bo‐Ying

doi:10.1016/j.jhazmat.2010.02.027

Cited by 30 publications

(20 citation statements)

References 24 publications

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“…The above results were consistent with those of other studies (Chang et al, 2010a;Shie et al, 2011). Among these detected compounds, the ethanol (381 ppb-2,480 ppb), acetone (123 ppb-624 ppb), and PGMEA (14.4 ppb-2,241ppb) were compounds dominated in all studied areas.…”

Section: Concentrations Of Each Individual Voc (C Voci ) In Thesupporting

confidence: 93%

“…The above findings are also very similar to those found in previous studies. For example, Chang et al (2010a) found that the ethanol (656.8 ppb-2,594 ppb), acetone (343.3 ppb-2066 ppb), isopropyl alcohol (1.7 ppb-388.5 ppb), and PGMEA (0.9 ppb-205.9 ppb) were the four dominant compounds in a total of ten VOCs identified in a TFT-LCD factory. Wu et al (2004) found the concentrations of PGMEA (252.7 ppb), butyl acetate (237.0 ppb), and acetone (75.9 ppb) in the workplace atmosphere of LCD fabrication facilities.…”

Section: Concentrations Of Each Individual Voc (C Voci ) In Thementioning

confidence: 99%

“…For high-tech industries, many studies have shown their exposure concentrations of an individual compound (such as ethanol, acetone, butyl acetate, isopropyl alcohol (IPA), and propylene glycol monomethyl ether acetate (PGMEA)) could be much lower than that of traditional industry, and particularly lower than their time-weighted-average permissible exposure concentrations (PEL-TWAs) (Zappe, 1995;Chuah et al, 2000;Wu et al, 2004;Chang et al, 2010a;Cheng et al, 2016;Chou et al, 2016;Guerra et al, 2017). Apparently, chemical exposures in the high-tech industry might not cause significant health risk posed on workers.…”

Section: Introductionmentioning

confidence: 99%

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Long-term Multiple Chemical Exposure Assessment for a Thin Film Transistor Liquid Crystal Display (TFT-LCD) Industry

Wang

Kuo

et al. 2017

Aerosol Air Qual. Res.

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A surrogate approach was deployed for assessing long-term exposures of multiple chemicals at 8 selected working areas of 3 manufacturing processes located at a clean room of a thin film transistor liquid crystal display (TFT-LCD) industry. For each selected area, 6 to 12 portable photoionization detector (PID) were placed uniformly in its workplace to measure its total VOCs concentrations (C T-VOCs ) for 6 randomly selected workshifts. Simultaneously, one canister was placed beside one of these portable PIDs, and the collected air sample was analyzed for individual concentration (C VOCi ) of 107 VOCs. Predictive models were established by relating the C T-VOCs to C VOCi of each individual compound via simple regression analysis. The established predictive models were employed to construct a year-long C VOCi databank based on the measured year-long C T-VOC for each selected area using the same portable PID. The ethanol (381 ppb-2,480 ppb), acetone (123 ppb-624 ppb) and propylene glycol monomethyl ether acetate 29 (PGMEA; 14.4 ppb-2,241 ppb) dominated in all selected areas, and all measured C VOCi were much lower than their permissible exposure limits. Predictive models obtained from simple linear regression analyses were found with an R 2 > 0.453 indicating that C T-VOCs were adequate for predicting C VOCi . The predicted year-long C VOCi reveals that long-term total multiple chemical exposures of all selected areas fall to the range 0.10%-20% of the permissible exposure level. Using the C T-VOCs as a surrogate for the routine checking purpose, the present study yielded allowable C T-VOCs fall to the ranges of 49.1 ppm-577 ppm. Considering the approach used in the present study requires less cost and manpower, it would be applicable to similar industries for conducting long-term multiple chemical exposure assessments in the future.

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Section: Concentrations Of Each Individual Voc (C Voci ) In Thesupporting

confidence: 93%

Section: Concentrations Of Each Individual Voc (C Voci ) In Thementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Long-term Multiple Chemical Exposure Assessment for a Thin Film Transistor Liquid Crystal Display (TFT-LCD) Industry

Wang

Kuo

et al. 2017

Aerosol Air Qual. Res.

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“…VOCs can have adverse effects on the human health and environment. Benzene, toluene, xylene isomers, phenol, and methyl ethyl ketone (MEK) are the most consumed VOCs and they are used in various industries (5)(6)(7). Benzene is a known human group 1 carcinogen [International Agency for Research on Cancer (IARC)] and skin A1 carcinogen [American Conference of Governmental Industrial Hygienists (ACGIH)], and causes hematotoxicity, aplastic anemia, acute myelogenous leukemia, and lymphoma (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Biological monitoring of petrochemical industry workers exposed to benzene, toluene, xylenes, methyl ethyl ketone, and phenol in Southern Iran

Rahimpoor

Bahrami

Assari

et al. 2014

JOHE

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Received: July 2015, Accepted: August 2015 Background: Volatile organic compounds (VOCs), including carcinogens and toxic compounds, are produced in petrochemical industries. We undertook this study in order to study workers' respiratory exposure to different VOC concentrations and compare the results with the urinary levels of its metabolites and study the correlation between them in petrochemical industries. Materials and Methods: Exposure to benzene, toluene, xylene isomers, phenol, and methyl ethyl ketone (MEK) was evaluated in 104 male subjects using personal sampling pump and charcoal sorbent tube at the breathing zone and analyzed using gas chromatography-mass spectrometry (GC-MS). The urine samples were analyzed using high-performance liquid chromatography (HPLC-UV) and gas chromatography-flame ionization detector (GC-FID). Results:The mean concentration of urinary trans,trans-muconic acid (t,t-MA), was 1431 µg/g creatinine and hippuric acid, methyl hippuric acid, phenol, and MEK were, 0.394, 0.444, 0.098 g/g creatinine, and 0.15 mg/l. The mean concentration of benzene in the breathing zone was greater than the threshold limit value (TLV) recommended by the American Conference of Governmental Industrial Hygienists (ACGIH). Conclusions:In this study, a more significant relationship was found between benzene in breathing zone and urinary t,t-MA in those exposed to benzene in concentrations higher than 1 ppm (r 2 = 0.89) than lower than 1 ppm. Moreover, the same results were observed for other hydrocarbons and their level of urinary biological index. A more significant relationship was observed between phenol in breathing zone and urine through exposure to airborne phenol in concentrations of higher than 0.049 ppm than lower than 0.049 ppm (r 2 = 0.75). The relationship between MEK in breathing zone and urinary MEK was more significant in concentrations of higher than 0.1 ppm (r 2 = 0.79) than lower than 0.1 ppm.

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“…[7] Some reports in the literature have indicated that VOCs emitted from TFT-LCD can be associated with kidney dysfunction in workers. [8] Therefore, it is important to determine the air pollution levels in the vicinity of electrical industry parks.…”

Section: Introductionmentioning

confidence: 99%

Concentration characteristics of VOCs and acids/bases in the gas phase and water-soluble ions in the particle phase at an electrical industry park during construction and mass production

Tsai

Huang

Shieh

et al. 2011

Journal of Environmental Science and Health, Part A

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The electronics industry is a major business in the Central Taiwan Science Park (CTSP). Particulate samples and 11 water-soluble ionic species in the particulate phase were measured by ionic chromatography (IC). Additionally, acid and base gases were sampled by denuder absorption and analyzed by IC. Volatile organic compounds (VOCs) were collected in stainless-steel canisters four times daily and analyzed via gas chromatography/mass spectrometry. Ozone formation potential (OFP) was measured using maximum increment reactivity. In addition, airborne pollutants during (1) construction and (2) mass production were measured. Particulate matter concentration did not increase significantly near the optoelectronic plant during construction, but it was higher than during mass production. SO(2), HNO(2) and NH(3) were the dominant gases in the denuder absorption system. Nitrate, sulfate, and ammonium ions predominated both in PM(2.5) and PM(10-2.5); but calcium ion concentration was significantly higher in PM(10-2.5) samples during construction. Toluene, propane, isopentane, and n-butane may have come from vehicle exhaust. Construction equipment emitted high concentrations of ethylbenzene, m-xylene, p-xylene, o-xylene, 1,2,4-trimethylbenzene, and toluene. During mass production, methyl ethyl ketone), acetone and ethyl acetate were significantly higher than during construction, although there was continuous rain. The aromatic group constituted >50% of the VOC concentration totals and contributed >70% of OFP.

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Exposure to volatile organic compounds and kidney dysfunction in thin film transistor liquid crystal display (TFT-LCD) workers

Cited by 30 publications

References 24 publications

Long-term Multiple Chemical Exposure Assessment for a Thin Film Transistor Liquid Crystal Display (TFT-LCD) Industry

Long-term Multiple Chemical Exposure Assessment for a Thin Film Transistor Liquid Crystal Display (TFT-LCD) Industry

Biological monitoring of petrochemical industry workers exposed to benzene, toluene, xylenes, methyl ethyl ketone, and phenol in Southern Iran

Concentration characteristics of VOCs and acids/bases in the gas phase and water-soluble ions in the particle phase at an electrical industry park during construction and mass production

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