Exposure to waterborne copper and high temperature induces the formation of reactive oxygen species and causes mortality in the Amazonian fish Hoplosternum littorale

Braz-Mota, Susana; Fé, Luciana Mara Lopes; Delunardo, Frederico Augusto Cariello; Sadauskas-Henrique­­­­, Helen; Almeida-Val, Vera Maria Fonseca de; Val, Adalberto Luís

doi:10.1007/s10750-016-2847-y

Cited by 24 publications

(12 citation statements)

References 42 publications

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“…Fish are gill-bearing aquatic organisms, and most of them are poikilothermic. It is well known that environmental parameters such as temperature, pH, and dissolved organic carbon all influence the toxicity effect and fish physiology [70][71][72][73][74][75][76][118][119][120].…”

Section: Piscesmentioning

confidence: 99%

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Antioxidative Defense and Fertility Rate in the Assessment of Reprotoxicity Risk Posed by Global Warming

Parisi

Guerriero

2019

Antioxidants

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The objective of this review is to briefly summarize the recent progress in studies done on the assessment of reprotoxicity risk posed by global warming for the foundation of strategic tool in ecosystem-based adaptation. The selected animal data analysis that was used in this paper focuses on antioxidative markers and fertility rate estimated over the period 2000–2019. We followed a phylogenetic methodology in order to report data on a panel of selected organisms that show dangerous effects. The oxidative damage studies related to temperature fluctuation occurring in biosentinels of different invertebrate and vertebrate classes show a consistently maintained physiological defense. Furthermore, the results from homeothermic and poikilothermic species in our study highlight the influence of temperature rise on reprotoxicity.

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Section: Piscesmentioning

confidence: 99%

“…In particular, Braz-Mota et al [76] investigated how the influence of temperature rise increases the chemical toxicity effect on the physiological responses of the Actinopterygii organism, the catfish Hoplosternum littorale.…”

Section: Piscesmentioning

confidence: 99%

Antioxidative Defense and Fertility Rate in the Assessment of Reprotoxicity Risk Posed by Global Warming

Parisi

Guerriero

2019

Antioxidants

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“…Cu can promote mitochondrial dysfunction and exert deleterious effects on metabolic energy production of fish (Sappal et al, 2014(Sappal et al, , 2015. Intracellular Cu accumulation beyond toxicity thresholds can lead to excessive generation of reactive oxygen species (ROS), facilitated by the redox-active nature of Cu, which can cycle between Cu + and Cu 2+ (Braz-Mota et al, 2017;Linder and Hazegh-Azam, 1996). Oxidative stress can alter electron transport capacity and/or disrupt mitochondrial membrane integrity, resulting in a decline in ATP production (Sappal et al, 2014(Sappal et al, , 2015.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of toxic action of copper and copper nanoparticles in two Amazon fish species: Dwarf cichlid (Apistogramma agassizii) and cardinal tetra (Paracheirodon axelrodi)

Braz-Mota

Campos

MacCormack

et al. 2018

Science of The Total Environment

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Copper oxide nanoparticles (nCuO) are widely used in boat antifouling paints and are released into the environment, potentially inducing toxicity to aquatic organisms. The present study aimed to understand the effects of nCuO and dissolved copper (Cu) on two ornamental Amazon fish species: dwarf cichlid (Apistogramma agassizii) and cardinal tetra (Paracheirodon axelrodi). Fish were exposed to 50% of the LC for nCuO (dwarf cichlid 58.31μgL and cardinal tetra 69.6μgL) and Cu (dwarf cichlid 20μgL and cardinal tetra 22.9μgL) for 24, 48, 72 and 96h. Following exposure, aerobic metabolic rate (ṀO), gill osmoregulatory physiology and mitochondrial function, oxidative stress markers, and morphological damage were evaluated. Our results revealed species specificity in metabolic stress responses. An increase of ṀO was noted in cardinal tetra exposed to Cu, but not nCuO, whereas ṀO in dwarf cichlid showed little change with either treatment. In contrast, mitochondria from dwarf cichlid exhibited increased proton leak and a resulting decrease in respiratory control ratios in response to nCuO and Cu exposure. This uncoupling was directly related to an increase in reactive oxygen species (ROS) levels. Our findings reveal different metabolic responses between these two species in response to nCuO and Cu, which are probably caused by the differences between species natural histories, indicating that different mechanisms of toxic action of the contaminants are associated to differential osmoregulatory strategies among species.

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“…Although there are several studies describing the effects of single metals and temperature in fish ( Abdel-Tawwab and Wafeek, 2017 ; Braz-Mota et al, 2017 ; Li et al, 2020 ), it is difficult to find information on metal mixtures combined with different temperature scenarios. In this study, common carp ( Cyprinus carpio ) were exposed to a sublethal metal mixture of Cu, Zn, and Cd using nominal metal concentrations reflecting the 10% of the 96 h-LC 50 (the concentration that is lethal to 50% of the population in 96 h) previously determined in our lab by Delahaut et al (2020) in fish kept at 20°C.…”

Section: Introductionmentioning

confidence: 99%

Temperature Effects During a Sublethal Chronic Metal Mixture Exposure on Common Carp (Cyprinus carpio)

et al. 2021

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The aquatic environment is the final sink of various pollutants including metals, which can pose a threat for aquatic organisms. Waterborne metal mixture toxicity might be influenced by environmental parameters such as the temperature. In the present study, common carp were exposed for 27 days to a ternary metal mixture of Cu, Zn, and Cd at two different temperatures, 10 and 20°C. The exposure concentrations represent 10% of the 96 h-LC50 (concentration lethal for the 50% of the population in 96 h) for each metal (nominal metal concentrations of Cu: 0.08 μM; Cd: 0.02 μM and Zn: 3 μM). Metal bioaccumulation and toxicity as well as changes in the gene expression of enzymes responsible for ionoregulation and induction of defensive responses were investigated. Furthermore the hepatosomatic index and condition factor were measured as crude indication of overall health and energy reserves. The obtained results showed a rapid Cu and Cd increase in the gills at both temperatures. Cadmium accumulation was higher at 20°C compared to 10°C, whereas Cu and Zn accumulation was not, suggesting that at 20°C, fish had more efficient depuration processes for Cu and Zn. Electrolyte (Ca, Mg, Na, and K) levels were analyzed in different tissues (gills, liver, brain, muscle) and in the remaining carcasses. However, no major electrolyte losses were observed. The toxic effect of the trace metal ion mixture on major ion uptake mechanisms may have been compensated by ion uptake from the food. Finally, the metal exposure triggered the upregulation of the metallothionein gene in the gills as defensive response for the organism. These results, show the ability of common carp to cope with these metal levels, at least under the condition used in this experiment.

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Exposure to waterborne copper and high temperature induces the formation of reactive oxygen species and causes mortality in the Amazonian fish Hoplosternum littorale

Cited by 24 publications

References 42 publications

Antioxidative Defense and Fertility Rate in the Assessment of Reprotoxicity Risk Posed by Global Warming

Antioxidative Defense and Fertility Rate in the Assessment of Reprotoxicity Risk Posed by Global Warming

Mechanisms of toxic action of copper and copper nanoparticles in two Amazon fish species: Dwarf cichlid (Apistogramma agassizii) and cardinal tetra (Paracheirodon axelrodi)

Temperature Effects During a Sublethal Chronic Metal Mixture Exposure on Common Carp (Cyprinus carpio)

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