Exposures to Endocrine Disrupting Chemicals in Consumer Products—A Guide for Pediatricians

Wong, Katelyn H; Durrani, Timur S.

doi:10.1016/j.cppeds.2017.04.002

Cited by 61 publications

(46 citation statements)

References 101 publications

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“…Endocrine disrupting chemicals (EDCs) are ubiquitous in modern society due to their widespread use in consumer products (e.g., food and beverage containers), personal care products (e.g., lotion), and medical supplies (e.g., plastic tubing). Phthalates and bisphenol A (BPA) are two of the most commonly studied EDCs, and both human and animal studies suggest these chemicals can disrupt normal biological processes [1]. BPA can impact endocrine function by acting as an estrogenic [2] and anti-androgenic compound [3].…”

Section: Introductionmentioning

confidence: 99%

Maternal levels of endocrine disrupting chemicals in the first trimester of pregnancy are associated with infant cord blood DNA methylation

et al. 2018

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Endocrine disrupting chemicals (EDCs) pose a public health risk through disruption of normal biological processes. Identifying toxicoepigenetic mechanisms of developmental exposure-induced effects for EDCs, such as phthalates or bisphenol A (BPA), is essential. Here, we investigate whether maternal exposure to EDCs is predictive of infant DNA methylation at candidate gene regions. In the Michigan Mother-Infant Pairs (MMIP) cohort, DNA was extracted from cord blood leukocytes for methylation analysis by pyrosequencing (n = 116) and methylation changes related to first trimester levels of 9 phthalate metabolites and BPA. Growth and metabolism-related genes selected for methylation analysis included imprinted (IGF2, H19) and non-imprinted (PPARA, ESR1) genes along with LINE-1 repetitive elements. Findings revealed decreases in methylation of LINE-1, IGF2, and PPARA with increasing phthalate concentrations. For example, a log unit increase in ΣDEHP corresponded to a 1.03 [95% confidence interval (CI): -1.83, -0.22] percentage point decrease in PPARA methylation. Changes in DNA methylation were also inversely correlated with PPARA gene expression determined by RT-qPCR (r = -0.34, P = 0.02), thereby providing evidence in support of functional relevance. A sex-stratified analysis of EDCs and DNA methylation showed that some relationships were female-specific. For example, urinary BPA exposure was associated with a 1.35 (95%CI: -2.69, -0.01) percentage point decrease in IGF2 methylation and a 1.22 (95%CI: -2.27, -0.16) percentage point decrease in PPARA methylation in females only. These findings add to a body of evidence suggesting epigenetically labile regions may provide a conduit linking early exposures with disease risk later in life and that toxicoepigenetic susceptibility may be sex specific.

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Section: Introductionmentioning

confidence: 99%

Maternal levels of endocrine disrupting chemicals in the first trimester of pregnancy are associated with infant cord blood DNA methylation

et al. 2018

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“…Many chemicals in personal care and consumer products such as preservatives, UV filters, plasticizers, fragrances, antimicrobials, pesticides and flame retardants are suspected to have or are recognised as endocrine system disruptors [1, 2]. Unfortunately, there is lack or limited understanding of the extent and patterns of human exposure to these chemicals.…”

Section: Introductionmentioning

confidence: 99%

A new analytical framework for multi-residue analysis of chemically diverse endocrine disruptors in complex environmental matrices utilising ultra-performance liquid chromatography coupled with high-resolution tandem quadrupole time-of-flight mass spectrometry

2018

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This manuscript presents a comprehensive analytical framework for identification and quantification of chemically diverse endocrine disrupting chemicals (EDCs) used in personal care and consumer products in diverse solid and liquid environmental matrices with an ultimate goal of evaluating public exposure to EDCs via water fingerprinting. Liquid chromatography coupled with tandem quadrupole time-of-flight mass spectrometry (UHPLC-ESI-MS/MS) was used for targeted analysis of selected EDCs as well as to identify and quantify a few metabolites using post-acquisition data mining. Solid-phase extraction (SPE) was applied to liquid matrices in order to reduce matrix effects and provide required sample concentration and ultimately, high sensitivity and selectivity of measurements. SPE recoveries in liquid samples ranged from 49 to 140% with method quantification limits not exceeding 1 ng L−1 for the majority of EDCs. Microwave-assisted extraction (MAE) was applied to solid samples and when followed by SPE, it permitted the analysis of EDCs in digested sludge. MAE/SPE recoveries varied from 11 to 186% and MQLs between 0.03 and 8.1 ng g−1 with the majority of compounds showing MQLs below 2 ng g−1. Mass error for quantifier and qualifier ions was below 5 ppm when analysing river water and effluent wastewater and below 10 ppm when analysing influent wastewater and solid samples. The method was successfully applied to environmental samples, with 33 EDCs identified and quantified in wastewater and receiving waters. In addition, several EDCs were found in digested sludge, which confirms that for a more comprehensive understanding of exposure patterns and environmental impact, analysis of solids cannot be neglected. Finally, post-acquisition data mining permitted the identification and quantification of a metabolite of BPA and the identification of a metabolite of 4-Cl-3-methylphenol. Graphical abstractᅟ Electronic supplementary materialThe online version of this article (10.1007/s00216-018-1483-y) contains supplementary material, which is available to authorized users.

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“…According to the Fourth National Report on Human Exposure to Environmental Chemicals, nearly all Americans in every age group (6 years or older) have detectable concentration of bisphenol A, phthalate metabolites, triclosan, and other widespread EDCs in their urine. The current recommendations by scientific organizations, including: the World Health Organization and the United Nations Environment Program, the Endocrine Society and the American Academy of Pediatrics, recomended minimizing exposures to endocrine disrupting chemicals [2]. Also the Polish Society of Endocrinology points out the harmful health effects caused by EDCs commonly applied in daily life as food contaminants, food and beverages containers, components of plastics, pharmaceuticals and cosmetics [3].…”

Section: Introductionmentioning

confidence: 99%

“…Prenatal and perinatal period, infancy, childhood, and puberty are critical time of development during which maturing systems are particularly sensitive to hormonal disruptions (small elimination of xenobiotics) [2]. EDCs have been found in materials intended for use by infants such as toys, teethers, flame retardant pajamas and baby bottles, as well as in food, (soy-based) infant formula, breast milk and also in polluted environment.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover infants and children often are exposed to consumer products that are not specifically dedicated for children (e.g., toothpaste, body wash, lotion and conditioner). Children have physiologically thinner skin than adults and also have greater skin surface area per unit of body weight, which may lead to greater exposures to triclosan, parabens and phthalates belonging to EDCs [2].…”

Section: Introductionmentioning

confidence: 99%

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Endocrine disruptor compounds in environment: As a danger for children health

Beszterda

Frański

2018

Pediatr Endocrino Diabetes Metab

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Endocrine disrupting compounds (EDCs) are heterogenous in structure and include synthetic organic compounds such as pharmaceutical agents, plant protection products, plastics, plasticizers, polychlorinated biphenyls, dioxins, flame-retardants, and antifoulant paint additive, as well, as natural plant-derived EDCs termed phytoestrogens and mycoestrogens. Children and adults are exposed daily to EDCs during drinking contaminated water, eating, breathing polluted air or direct contact with chemicals. Prenatal and perinatal period, infancy, childhood, and puberty are critical time of development during which maturing systems are particularly sensitive to hormonal disruptions (small elimination of xenobiotics). Exposure to environmental chemicals with estrogenic or antiandrogenic action may disrupt female reproductive tract development, also testosterone synthesis and sexual differentiation, leading to adult testis dysfunction and infertility. What is important, today there is still no definitive risk assessment tool for EDCs. Key words endocrine disrupting chemicals, persistent organic pollutants, reproductive system, obesogens Streszczenie Związki endokrynnie aktywne (ang. endocrine disrupting chemicals, EDCs) stanowią grupę syntetycznych organicznych związków o zróżnicowanej strukturze chemicznej, do których zaliczamy m.in.: wybrane farmaceutyki, środki ochrony roślin, tworzywa sztuczne, plastyfikatory, polichlorowane bifenyle, dioksyny, środki opóźniające palność, dodatki do farb czy związki pochodzenia naturalnego, takie jak fito-i mykoestrogeny. Podlegamy codziennej ekspozycji na EDCs podczas konsumpcji skażonej wody i żywności, oddychania zanieczyszczonym powietrzem lub poprzez bezpośredni kontakt z substancją aktywną. Jednakże okres pre-i perinatalny, niemowlęctwo, dzieciństwo oraz pokwitanie należą do krytycznych okresów rozwoju, podczas których podatność na wystąpienie zaburzeń hormonalnych pod wpływem bodźców chemicznych jest wysoka (niska eliminacja ksenobiotyków z ustroju). Narażenie na środowiskowe kontaminanty wykazujące działanie estrogenne lub anty-androgenne może zaburzać prawidłowy rozwój żeńskiego układu rozrodczego, syntezę testosteronu i proces różnicowania płciowego, co prowadzić może do dysfunkcji jąder i rozwoju niepłodności u osób dorosłych. Dotychczas nie opracowano jeszcze skutecznych narzędzi do oceny ryzyka wywołanego obecnością EDCs w środowisku. Słowa kluczowe związki endokrynnie aktywne, trwałe zanieczyszczenia organiczne, układ rozrodczy, obesogeny

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Exposures to Endocrine Disrupting Chemicals in Consumer Products—A Guide for Pediatricians

Cited by 61 publications

References 101 publications

Maternal levels of endocrine disrupting chemicals in the first trimester of pregnancy are associated with infant cord blood DNA methylation

Maternal levels of endocrine disrupting chemicals in the first trimester of pregnancy are associated with infant cord blood DNA methylation

A new analytical framework for multi-residue analysis of chemically diverse endocrine disruptors in complex environmental matrices utilising ultra-performance liquid chromatography coupled with high-resolution tandem quadrupole time-of-flight mass spectrometry

Endocrine disruptor compounds in environment: As a danger for children health

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