Express Screening of Biological Objects Using Multisensor Stripping Voltamperometry with Pattern Recognition

Abstract

Express diagnostics of biological objects is necessary for operational preliminary assessment of the condition of the patient. A method of recognition of differences between the norm and pathology is based on analysis of multidimensional patterns of the voltamperogram electrochemical test systems in Electronic formats "language", "electronic nose". The basis of such systems is the use of a set (matrix) sensor with completely different characteristics. A. N. Frumkin Institute of Physical Chemistry and Electrochemistry RAS (IPCE) developed a method for multidimensional stripping voltammetry, which allowed you to provide information on biological matter being investigated not as a number, as a response to a single dimension, and in the form of N-dimensional image. Formats are implemented in the process of electrochemical studies of liquid or gaseous phase. Evaluating the closeness of the resulting image object under test with known samples is collected in a database. Examples of express diagnostics of glaucoma are with accordance of the results of the electrochemical research of blood serum.

Development of a Method for Multisensory Stripping Voltammetry in the Analysis of Medical Preparations

“…Electrochemical inversion methods cannot, in principle, be used for continuous determinations because of the need for sequential stages of accumulation and dissolution; however, they are suitable for performing automatic serial analyzes during certain time intervals if suitable programming equipment is available. , Examples are software-controlled devices that use a stationary mercury drip electrode − and a rotating mercury film electrode. − …”

“…Further studies have shown the working capacity and effectiveness of the method, in particular, when analyzing a number of ophthalmic drugs: Visomitin and Lanosterol . An increase in the strength of the complex present in the background increases the height of the peak of the metal dissolution current and, accordingly, decreases its width. − Assessment of the dynamics of changes in their concentration in the lacrimal fluid over time must determine the effective dosage of newly developed analgesic ophthalmic drugs. This study aimed to study the behavioral pharmacokinetics in the lacrimal fluid of an opioid drug, sevoflurane, in pediatric ophthalmology using multisensory stripping voltammetry in patients during strabismus correction surgery.…”

Analysis of Tear Fluid for Evaluation on the Concentration of the Generic Anti-Glaucoma Drug Betoptik using Multisensory Stripping Voltammetry and Multivariate Statistics

“…The analyzer embodies a new approach using a solution containing various metal ions as an electrochemical testsystem, the ions being able interact with organic substances to form complex compounds [21][22][23][24][25][26][27][28][29][30][31]. All known E-tongue devices use a set of electrodes as sensors, therefore the reproducibility of characteristics of the multi-sensor systems is problematic, which affects the reliability and pattern recognition in a negative way.…”

“…Measurements are performed on a single indicator electrode, which has a significant advantage compared to multi-sensor methods using a range of electrodes. This method allows the identification of organic substances using a preliminary database.The effectiveness of this method has been shown for several ophthalmic medications: Visomitin, Betoptic, and Lanomax [27][28][29][30]. The concentration of Visomitin in the lacrimal fluid was measured based on a calibration relationship.…”