Expression analysis of genes responsible for serotonin signaling in the brain

Ichikawa, Manabu; Okamura-Oho, Yuko; Okunishi, Rie; Kanamori, Mutsumi; Suzuki, Harukazu; Ritani, Akishige; Nitta, Hiroaki; Eguchi, Naomi; Urade, Yoshihiro; Hayashizaki, Yoshihide

doi:10.1016/j.nbd.2005.01.021

Cited by 9 publications

(7 citation statements)

References 23 publications

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“…Recent work characterized the downstream targets of the MHb-IPN pathway and show that serotonergic raphe nuclei receive dense innervation from vMHbinnervated IPN neurons (Quina et al 2017). The MHb also densely expresses the 5-HT3A, -4, -5A and -5B receptors, suggesting that it receives serotonergic inputs, potentially from the same raphe-serotonergic population receiving innervation from the IPN (Filip et al 2004;Ichikawa et al 2005;Wagner et al 2014). It is possible that these inputs may be directly, but differentially, modulated by cocaine and nicotine.…”

Section: Discussionmentioning

confidence: 99%

Medial habenula cholinergic signaling regulates cocaine‐associated relapse‐like behavior

et al. 2018

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Propensity to relapse, even following long periods of abstinence, is a key feature in substance use disorders. Relapse and relapse-like behaviors are known to be induced, in part, by re-exposure to drug-associated cues. Yet, while many critical nodes in the neural circuitry contributing to relapse have been identified and studied, a full description of the networks driving reinstatement of drug-seeking behaviors is lacking. One area that may provide further insight to the mechanisms of relapse is the habenula complex, an epithalamic region composed of lateral and medial (MHb) substructures, each with unique cell and target populations. Although well conserved across vertebrate species, the functions of the MHb are not well understood. Recent research has demonstrated that the MHb regulates nicotine aversion and withdrawal. However, it remains undetermined whether MHb function is limited to nicotine and aversive stimuli or if MHb circuit regulates responses to other drugs of abuse. Advances in circuit-level manipulations now allow for cell-type and temporally specific manipulations during behavior, specifically in spatially restrictive brain regions, such as the MHb. In this study, we focus on the response of the MHb to reinstatement of cocaine-associated behavior, demonstrating that cocaine-primed reinstatement of conditioned place preference engages habenula circuitry. Using chemogenetics, we demonstrate that MHb activity is sufficient to induce reinstatement behavior. Together, these data identify the MHb as a key hub in the circuitry underlying reinstatement and may serve as a target for regulating relapse-like behaviors.

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Section: Discussionmentioning

confidence: 99%

Medial habenula cholinergic signaling regulates cocaine‐associated relapse‐like behavior

et al. 2018

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“…HTR1B is a G protein-coupled receptor that inhibits cyclic AMP formation (Murphy et al 1998). It is highly expressed in the dorsal raphe nucleus, which is involved in the sleep/wake cycle, and to lesser degrees in the striatum and frontal regions such as the dorsolateral prefrontal cortex (Ichikawa et al 2005). HTR1B "knockout" mice show increased aggression and impulsive behavior (Brunner and Hen 1997;Saudou et al 1994), fail to show Fig.…”

Section: Serotonin 1b Receptor (Htr1b; 5ht1b)mentioning

confidence: 99%

Candidate gene studies of ADHD: a meta-analytic review

2009

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Quantitative genetic studies (i.e., twin and adoption studies) suggest that genetic influences contribute substantially to the development of attention deficit hyperactivity disorder (ADHD). Over the past 15 years, considerable efforts have been made to identify genes involved in the etiology of this disorder resulting in a large and often conflicting literature of candidate gene associations for ADHD. The first aim of the present study was to conduct a comprehensive meta-analytic review of this literature to determine which candidate genes show consistent evidence of association with childhood ADHD across studies. The second aim was to test for heterogeneity across studies in the effect sizes for each candidate gene as its presence might suggest moderating variables that could explain inconsistent results. Significant associations were identified for several candidate genes including DAT1, DRD4, DRD5, 5HTT, HTR1B, and SNAP25. Further, significant heterogeneity was observed for the associations between ADHD and DAT1, DRD4, DRD5, DBH, ADRA2A, 5HTT, TPH2, MAOA, and SNAP25, suggesting that future studies should explore potential moderators of these associations (e.g., ADHD subtype diagnoses, gender, exposure to environmental risk factors). We conclude with a discussion of these findings in relation to emerging themes relevant to future studies of the genetics of ADHD.

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“…Moreover, using an informatics approach, we inspected the r values between genes that are known to co-localize within cells or in closely located cells. As shown in sample analyses of genes in the hypothalamus and the midbrain12131415, genes that are co-expressed in serotonergic neurons of the raphe nuclei, in other monoamine neurons of the midbrain and in magnocellular neurons or other functional neurons of the hypothalamic nuclei displayed r values higher than 0.85 (Fig. 1C).…”

Section: Resultsmentioning

confidence: 74%

“…The node positions of the genes that are selectively expressed in a type of cells are close in the graph. Consequently, the graphs represent anatomical and functional regions, as indicated by dotted lines and names12131415. Thick and thin lines: r > 0.85 and > 0.7, respectively, show that r > 0.85 is sufficiently high to reveal groups of genes that are present in particular regions or cell types.…”

Section: Figurementioning

confidence: 99%

Broad Integration of Expression Maps and Co-Expression Networks Compassing Novel Gene Functions in the Brain

Okamura-Oho

Shimokawa

Nishimura

et al. 2014

Sci Rep

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Using a recently invented technique for gene expression mapping in the whole-anatomy context, termed transcriptome tomography, we have generated a dataset of 36,000 maps of overall gene expression in the adult-mouse brain. Here, using an informatics approach, we identified a broad co-expression network that follows an inverse power law and is rich in functional interaction and gene-ontology terms. Our framework for the integrated analysis of expression maps and graphs of co-expression networks revealed that groups of combinatorially expressed genes, which regulate cell differentiation during development, were present in the adult brain and each of these groups was associated with a discrete cell types. These groups included non-coding genes of unknown function. We found that these genes specifically linked developmentally conserved groups in the network. A previously unrecognized robust expression pattern covering the whole brain was related to the molecular anatomy of key biological processes occurring in particular areas.

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Expression analysis of genes responsible for serotonin signaling in the brain

Cited by 9 publications

References 23 publications

Medial habenula cholinergic signaling regulates cocaine‐associated relapse‐like behavior

Medial habenula cholinergic signaling regulates cocaine‐associated relapse‐like behavior

Candidate gene studies of ADHD: a meta-analytic review

Broad Integration of Expression Maps and Co-Expression Networks Compassing Novel Gene Functions in the Brain

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