Expression and characterization of a constitutively active STAT6 from Tetraodon

Sung, Shu Chiun; Cheng, Chia Hsiung; Chou, Chih Ming; Chu, Cheng Ying; Chen, Gen Der; Hwang, Pung Pung; Huang, Fore‐Lien; Huang, Chang Jen

doi:10.1016/j.fsi.2010.01.015

Cited by 9 publications

(3 citation statements)

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“…55 Some evolutionary studies support the idea that prior to the existence of IgE in mammals, some stimuli (for example, bacterial toxins) could elicit an allergic-like inflammatory response, including hypersensitivity and shock reactions in fish. 297 Teleost in general, dating back more than 300 million years, have several genes that code for components of the Th2 response, 298 as well as effector cells (mast cells, eosinophils, and basophils) that are activated against certain antigenic stimuli in a similar way to those of mammals, 299 which suggests, at least since the appearance of these organisms, that an immune response similar to what we now know as allergic has occurred. Th2 lymphocytes, which probably predate IgE, 300 are an important source, along with type 2 ILCs, of IL-4 and IL-13.…”

Section: -The Allergen Conceptmentioning

confidence: 99%

EAACIMolecular Allergology User's Guide 2.0

Dramburg

Hilger

Santos

et al. 2023

Pediatric Allergy Immunology

119

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Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE‐mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well‐defined, highly pure molecules for component‐resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state‐of‐the‐art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.

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Section: -The Allergen Conceptmentioning

confidence: 99%

EAACIMolecular Allergology User's Guide 2.0

Dramburg

Hilger

Santos

et al. 2023

Pediatric Allergy Immunology

119

View full text Add to dashboard Cite

show abstract

“…Aunque hay células de la inmunidad innata que producen IL-4 e IL-13, los linfocitos son necesarios para la producción de IgE, pues a través de señales por contacto intercelular (CD40/CD40L) inducen el cambio de isotipo en los linfocitos B hacia la cadena pesada épsilon (16). Los teleósteos, que datan de hace más de 300 millones de años, tienen varios genes que codifican para componentes de la respuesta Th2 (17), así como células efectoras (mastocitos, eosinófilos y basófilos) que se activan frente a ciertos estímulos antigénicos de una manera similar a como lo hacen las de los mamíferos (18), lo cual sugiere que desde la aparición de los peces se dio una respuesta inmunitaria parecida a la que conocemos ahora como alérgica.…”

Section: Algunos Aspectos De La Filogenia De La Respuesta Th2unclassified

“…La conservación de esta propiedad concuerda con la gran similitud de la secuencia de aminoácidos que existe entre las regiones de unión al ADN de estos genes. Aunque los aminoácidos del dominio SH2 que influyen en la unión del HsSTAT6 al receptor de la IL-4 se conservan en el TnSTAT6, no se pudo activar este factor de transcripción mediante estímulo con IL-4 de mamífero (17).…”

Section: Citocinas Y Receptoresunclassified