Expression and Diagnostic Evaluation of the Human Tumor–Associated Antigen RCAS1 in Pancreatic Cancer

Akashi, Tomoyuki; Oimomi, Hideki; Nishiyama, Ken Ichi; Nakashima, Mitsuyoshi; Arita, Yoshiyuki; Sumii, Toshihiko; Kimura, Toshinari; Ito, Tetsuhide; Nawata, Hajime; Watanabe, Takeshi

doi:10.1097/00006676-200301000-00009

Cited by 44 publications

(47 citation statements)

References 31 publications

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“…Although previous results [13,14] have demonstrated the correlation between the staining level and tumor stage or differentiation status, this study did not find any significant correlation between them. Most metastatic tumor cells showed a high intensity of RCAS1 immunostaining.…”

Section: Resul Resul Resul Resul Results Ts Tscontrasting

confidence: 99%

“…As suspected, it was expressed in all cases of metastatic lymph nodes. RCAS1 was shown to be a ligand for a putative receptor on immune cells such as T cells and natural killer cells [7][8][9][10][11][12][13][14] . Scientists suggest that RCAS1 may play a protective role in tumor cells against immune surveillance by inhibition of clonal expression and inducing receptor-expressing cell death.…”

Section: Resul Resul Resul Resul Results Ts Tsmentioning

confidence: 99%

“…This tumor-associated antigen has been demonstrated in several kinds of gastrointestinal cancer by immunohistochemical study using the specific mouse mAb, 22-1-1. The result of RCAS1 expression was evaluated for the percent incidence in various cancers including gall bladder cancer (70%) [9] , cholangiocarcinoma (85.9-96.4%) [10,11] , gastric cancer (54.3%) [12] , pancreatic cancer (100%) [13] , and colorectal cancer (100%) [14] . However, until now, there has been no intensive study about the expression of RCAS1 in lymph node metastasis from gastrointestinal cancer.…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

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Receptor-binding cancer antigen expressed on SiSo cells can be detected in metastatic lymph nodes from gastrointestinal cancers

Leelawat

Engprasert²,

Tujinda³

et al. 2005

WJG

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Abstract Abstract Abstract AIM:To investigate the expression of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) in metastatic lymph nodes from gastrointestinal cancer. METHODS:Metastatic lymph nodes from gastrointestinal cancer were detected for RCAS1 by immunohistochemical staining and mRNA in situ hybridization. RESULTS:A total of 102 metastatic lymph nodes from bile duct, gastric, colon, and pancreatic cancer were investigated for RCAS1 expression. The immunoreactivity of RCAS1 was identified in 100% of metastatic lymph nodes. Both local and distant metastatic lymph nodes showed RCAS1 expression. On the contrary, specimens of non-cancerous lymph nodes were negative for RCAS1. The result of mRNA in situ hybridization was also confirmed by the finding of immunohistochemical staining. RCAS1 mRNA was detected in all tumor cells that metastasized to lymph nodes. CONCLUSION:All metastatic lymph nodes express RCAS1 in tumor cells at both protein and mRNA levels, and RCAS1 should be used as a complementary factor for identification of metastatic lymph nodes from gastrointestinal cancers.

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Section: Resul Resul Resul Resul Results Ts Tscontrasting

confidence: 99%

Section: Resul Resul Resul Resul Results Ts Tsmentioning

confidence: 99%

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

See 1 more Smart Citation

Receptor-binding cancer antigen expressed on SiSo cells can be detected in metastatic lymph nodes from gastrointestinal cancers

Leelawat

Engprasert²,

Tujinda³

et al. 2005

WJG

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show abstract

“…Moreover, we should examine the expression of RCAS1 in another kinds of canine tumor. Soluble RCAS1 is present in the culture media of breast cancer and cholangiocarcinoma cell lines, the vaginal discharges of uterine cervical cancer patients, and the sera of pancreatic cancer patients [1,5,26,28]. The determination of serum RCAS1 expression by ELISA is now useful in pancreatic cancer [1].…”

Section: Discussionmentioning

confidence: 99%

“…RCAS1 has also been detected in nongynecological cancers such as human breast carcinomas [26,32,36], esophageal squamous cell carcinomas [19], gastric adenocarcinomas [6,16], hepatocellular carcinomas [2,21], lung cancers [13,14,22], and pancreatic adenocarcinomas [1,19]. Expression of RCAS1 is associated with a poor prognosis in these cancer patients.…”

mentioning

confidence: 99%

Expression of a Tumor-Associated Antigen, RCAS1, in Canine Mammary Tumors

et al. 2004

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ABSTRACT. Receptor-binding cancer antigen expressed on SiSo cells (RCAS1), one of novel cancer cell-surface antigens, is strongly expressed in invasive cancers. RCAS1 inhibits the in vitro growth of lymphocytes such as T cells and natural killer (NK) cells, and induces apoptotic cell death. We investigated the expression of RCAS1 in canine mammary tumor cell lines and tumor cells by immunohistochemistry, and also in situ deoxyribonucleic acid (DNA) fragmentation in tumor-infiltrating lymphocytes (TILs) by the terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate nick end labeling (TUNEL) method. All canine mammary tumor cell lines expressed RCAS1 at both the messenger ribonucleic acid (mRNA) and protein level. Immunohistochemically, RCAS1 was negative in 100% of normal mammary glands, but was expressed in 100% of malignant tumors examined. In most malignant mammary tumors, RCAS1 was localized in the cytoplasm with no polarity of expression. In benign mammary tumors, it was detected on the luminal surface of the tumor cell. RCAS1 expression or localization was significantly correlated with malignancy. In situ DNA fragmentation of CD3-positive TILs was observed in RCAS1-expressing tumors. RCAS1-expressing tumors, indicating a possible induction of apoptotic cell death in TILs through RCAS1 expression. These observations suggest that RCAS1 probably plays an important role in tumor progression and escape from immune surveillance in canine mammary tumors. KEY WORDS: canine mammary tumor, DNA fragmentation, immunohistochemistry, receptor-binding cancer antigen expressed on SiSo cells (RCAS1), tumor infiltrating lymphocyte (TILs).

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Endoscopy in Pancreatic Cancer: An Oncologist's Perspective

Lee¹

2013

Gastrointestinal Endoscopy in the Cancer Patient

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Expression and Diagnostic Evaluation of the Human Tumor–Associated Antigen RCAS1 in Pancreatic Cancer

Cited by 44 publications

References 31 publications

Receptor-binding cancer antigen expressed on SiSo cells can be detected in metastatic lymph nodes from gastrointestinal cancers

Receptor-binding cancer antigen expressed on SiSo cells can be detected in metastatic lymph nodes from gastrointestinal cancers

Expression of a Tumor-Associated Antigen, RCAS1, in Canine Mammary Tumors

Endoscopy in Pancreatic Cancer: An Oncologist's Perspective

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