Expression and distribution of brain natriuretic peptide in human right atria

Doyama, Kiyoshi; Fukumoto, Manabu; Takemura, Genzou; Tanaka, Masaru; Oda, Teiji; Hasegawa, Koji; Inada, Tsukasa; Ohtani, Seiji; Fujiwara, Takako; Itoh, Hiroshi; Nakao, Kazuwa; Sasayama, Shígetake; Fujiwara, Hisayoshi

doi:10.1016/s0735-1097(98)00494-x

Cited by 71 publications

(44 citation statements)

References 33 publications

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“…Indeed, contradictory data are available on the regulation of ANP and BNP in the atria during the development of heart failure. Our findings support previous studies by Pemberton et al (1997) and Doyama et al (1998). The former demonstrated that the ANP:BNP mRNA ratio in the atrium was not changed after induction of CHF by rapid ventricular pacing in sheep, compared with control animals.…”

Section: Discussionsupporting

confidence: 92%

“…The former demonstrated that the ANP:BNP mRNA ratio in the atrium was not changed after induction of CHF by rapid ventricular pacing in sheep, compared with control animals. Similar observations were reported by Doyama et al (1998), who examined the expression of these peptides by Northern blotting analysis in the right atria of patients undergoing cardiac surgery. Their findings suggest that ANP and BNP share a common regulatory mechanism and that their synthesis may be commonly associated with atrial stretch.…”

Section: Discussionsupporting

confidence: 83%

“…BNP is considered to be a more reliable prognostic marker than ANP in patients with CHF (Friedl et al 1999), and BNP levels found in the atrium are proportionally related to the severity of the disease (Mukoyama et al 1991;Langenickel et al 2000). Doyama et al (1998) observed that BNP levels rise in response to increased atrial pressure and that atrial expression of BNP mRNA is correlated with that of ANP, assuming that these two genes may share some common regulatory mechanism, of which atrial pressure was suggested to be of major importance. In contrast, Moe et al (1996) demonstrated that both ANP and BNP are activated in heart failure.…”

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confidence: 99%

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Evaluation of Atrial Natriuretic Peptide and Brain Natriuretic Peptide in Atrial Granules of Rats with Experimental Congestive Heart Failure

Bialik

Abassi²,

Hammel

et al. 2001

J Histochem Cytochem.

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S U M M A R YThe natriuretic peptides are believed to play an important role in the pathophysiology of congestive heart failure (CHF). We utilized a quantitative cytomorphometric method, using double immunocytochemical labeling, to assess the characteristics of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in atrial granules in an experimental model of rats with CHF induced by aortocaval fistula. Rats with CHF were further divided into decompensated (sodium-retaining) and compensated (sodium-excreting) subgroups and compared with a sham-operated control group. A total of 947 granules in myocytes in the right atrium were analyzed, using electron microscopy and a computerized analysis system. Decompensated CHF was associated with alterations in the modal nature of granule content packing, as depicted by moving bin analysis, and in the granule density of both peptides. In control rats, the mean density of gold particles attached to both peptides was 347.0 Ϯ 103.6 and 306.3 Ϯ 89.9 gold particles/ m 2 for ANP and BNP, respectively. Similar mean density was revealed in the compensated rats (390.6 Ϯ 81.0 and 351.3 Ϯ 62.1 gold particles/ m 2 for ANP and BNP, respectively). However, in rats with decompensated CHF, a significant decrease in the mean density of gold particles was observed (141.6 Ϯ 67.3 and 158.0 Ϯ 71.2 gold particles/ m 2 for ANP and BNP, respectively; p Ͻ 0.05 compared with compensated rats, for both ANP and BNP). The ANP:BNP ratio did not differ between groups. These findings indicate that the development of decompensated CHF in rats with aortocaval fistula is associated with a marked decrease in the density of both peptides in atrial granules, as well as in alterations in the quantal nature of granule formation. The data further suggest that both peptides, ANP and BNP, may be regulated in the atrium by a common secretory mechanism in CHF.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 83%

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confidence: 99%

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Evaluation of Atrial Natriuretic Peptide and Brain Natriuretic Peptide in Atrial Granules of Rats with Experimental Congestive Heart Failure

Bialik

Abassi²,

Hammel

et al. 2001

J Histochem Cytochem.

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“…BNP mRNA is expressed in atrial muscle, where BNP is also secreted; both have been reported to increase by atrial fibrillation and hypertrophy (24,(29)(30)(31)(32). Although the kinetics of atrial-derived BNP in heart failure are not fully known, some studies (23)(24)(25) propose that the atrium is the major source of secretion in the early stage of lowered cardiac function, and that BNP levels from the ventricle increase after the progression to heart failure.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of the brain natriuretic peptide to atrial natriuretic peptide ratio in determining the severity of mitral regurgitation

Shimamoto

Kusumoto

Sakai

et al. 2007

Canadian Journal of Cardiology

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I n chronic mitral regurgitation (MR), increased preload and reduced afterload due to unloading from the left ventricle (LV) into the left atrium (LA) leads to compensatory dilation of the LV and facilitates LV ejection. Although this response initially maintains cardiac output, myocardial decompensation eventually results in heart failure symptoms and an increased risk of sudden death. In addition, backflow into the LA results in enlargement of the LA, atrial fibrillation and elevated pulmonary pressures. In some patients, LV contractility is irreversibly impaired in the absence of symptoms (1-3). Thus, deferring surgical intervention often leads to irreversible postoperative LV dysfunction. Valve replacement or valvuloplasty is essential before the myocardial damage becomes irreversible.Early valvuloplasty conducted when heart failure is mild has been reported to improve prognosis (4). In clinical practice, however, it remains difficult to decide the timing of surgery defined by mild heart failure symptoms and preserved cardiac function.Some reports have shown that preoperative LV function (LV end-diastolic diameter [LVDd], LV end-systolic diameter BACKGROUND: Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels were characterized in subjects with mitral regurgitation (MR). METHODS: Sixty-two cases of moderate or severe chronic MR were studied. The blood levels of neurohormonal factors were stratified by the known MR prognostic factors of New York Heart Association (NYHA) functional class, left ventricular end-diastolic diameters, left ventricular end-systolic diameter (LVDs), ejection fraction (EF), left atrial diameter and presence of atrial fibrillation (AF). RESULTS: ANP levels were higher in NYHA class II and lower in classes I and III/IV (P=0.0206). BNP levels were higher in NYHA class II than class I (P=0.0355). The BNP/ANP ratio was significantly higher in NYHA classes II and III/IV than in class I (P=0.0007). To differentiate between NYHA classes I/II and III/IV, a cut-off BNP/ANP ratio of 2.97 produced a sensitivity of 78% and specificity of 87%. Compared with subjects in sinus rhythm, patients with AF had an enlarged left atrium and lower ANP levels. The BNP/ANP ratio correlated significantly with left atrial diameter, LVDs and EF (r=0.429, P=0.0017; r=0.351, P=0.0117; and r=-0.349, P=0.0122; respectively), and was significantly higher among all the known operative indications for MR tested (LVDs 45 mm or more, EF 60% or less, NYHA class II or greater and AF; P=0.0073, P=0.003, P=0.0102 and P=0.0149, respectively). CONCLUSIONS: In chronic MR, levels of ANP and BNP, and the BNP/ANP ratio are potential indicators of disease severity.

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“…Under normal circumstances the myocytes in the atria and the ventricles in the human heart will produce ANP to regulate fluid homeostasis [8,9] but when the ventricles and atria in the heart are stretched, the synthesis of these peptides increases. ANP gene expression is increased in the ventricular myocardium of the failing heart proportionally with the severity of congestive heart failure or ventricular haemodynamic overload [10]. Therefore resting levels of natriuretic peptides are higher in chronic heart failure and atrial fibrillation compared with normal [1,11,12].…”

Section: Introductionmentioning

confidence: 99%

Mr-Proanp Rises during Exercise Even after Surgical Closure of the Left Atrial Appendage: A Sub-Study of the Laacs Randomized Study

Park-Hansen¹

2019

Journal of Cardiology and Vascular Medicine

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Methods: A group of 19 patients who had undergone elective open heart surgery, and who had been randomized to either the LAA-closure group (n=9), or to the LAA-open group (n=10) performed a standard bicycle exercise test, at least six weeks after the operation. Closure of the LAA was confirmed by Transesophageal Echocardiography (TEE). Venous blood samples were collected before the test, and within the first two minutes of recovery after maximum work-load. Conclusion: This study shows that plasma MR-proANP increases during exercise, and that surgical LAA closure did not reduce the increase of MR-proANP in response to physical exercise. These findings indicate that other areas of the heart elicit most of the MR-proANP production Journal of Cardiology and Vascular Medicine Results:

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Expression and distribution of brain natriuretic peptide in human right atria

Abstract: Expression of BNP and BNP mRNA is augmented in the atria with increased pressure, and distributed predominantly in the subendocardial side. The level of BNP mRNA was well correlated with that of ANP mRNA. Thus, these two genes might be commonly regulated in response to atrial pressure.

Cited by 71 publications

References 33 publications

Evaluation of Atrial Natriuretic Peptide and Brain Natriuretic Peptide in Atrial Granules of Rats with Experimental Congestive Heart Failure

Evaluation of Atrial Natriuretic Peptide and Brain Natriuretic Peptide in Atrial Granules of Rats with Experimental Congestive Heart Failure

Usefulness of the brain natriuretic peptide to atrial natriuretic peptide ratio in determining the severity of mitral regurgitation

Mr-Proanp Rises during Exercise Even after Surgical Closure of the Left Atrial Appendage: A Sub-Study of the Laacs Randomized Study

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