2009
DOI: 10.1590/s0001-37652009000300002
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Expression and function of G-protein-coupled receptorsin the male reproductive tract

Abstract: This review focuses on the expression and function of muscarinic acetylcholine receptors (mAChRs), α 1 -adrenoceptors and relaxin receptors in the male reproductive tract. The localization and differential expression of mAChR and α 1 -adrenoceptor subtypes in specific compartments of the efferent ductules, epididymis, vas deferens, seminal vesicle and prostate of various species indicate a role for these receptors in the modulation of luminal fluid composition and smooth muscle contraction, including effects o… Show more

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Cited by 16 publications
(10 citation statements)
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“…Transcripts encoding all three α 1 -adrenoceptors have been found in organs of the male reproductive tract from rodents and humans, albeit in different proportions with relatively similar levels for α 1Aand α 1Dbut lower levels for α 1B -adrenoceptors (Avellar, Lazari, & Porto, 2009;Burt, Chapple, & Marshall, 1995;Mendes, Hamamura, Queiroz, Porto, & Avellar, 2004;Pacini, Castilho, Hebeler-Barbosa, Pupo, & Kiguti, 2018;Pupo, 1998;Queiroz, Mendes, Porto, & Avellar, 2002;Silva, Megale, Avellar, & Porto, 1999;Yono et al, 2012). However, in isolated tissue preparations, the contractions of these organs in response to α 1 -adrenoceptor agonists are often described as mediated by the α 1A -subtype (Avellar et al, 2009;Burt et al, 1995;Mendes et al, 2004;Pacini et al, 2018;Pupo, 1998;Silva et al, 1999;Yono et al, 2012). Importantly, the contractions of the mouse and rat vas deferens in response to electrical field stimulation have been described to involve α 1Dadrenoceptors, and at least in the mouse vas deferens, these receptors seem to play a role in contractions to exogenous noradrenaline (Bexis et al, 2008;Cleary, Slattery, Bexis, & Docherty, 2004;Mallard, Marshall, Sithers, & Spriggs, 1992).…”
Section: α 1 -Adrenoceptors In the Heartmentioning
confidence: 99%
“…Transcripts encoding all three α 1 -adrenoceptors have been found in organs of the male reproductive tract from rodents and humans, albeit in different proportions with relatively similar levels for α 1Aand α 1Dbut lower levels for α 1B -adrenoceptors (Avellar, Lazari, & Porto, 2009;Burt, Chapple, & Marshall, 1995;Mendes, Hamamura, Queiroz, Porto, & Avellar, 2004;Pacini, Castilho, Hebeler-Barbosa, Pupo, & Kiguti, 2018;Pupo, 1998;Queiroz, Mendes, Porto, & Avellar, 2002;Silva, Megale, Avellar, & Porto, 1999;Yono et al, 2012). However, in isolated tissue preparations, the contractions of these organs in response to α 1 -adrenoceptor agonists are often described as mediated by the α 1A -subtype (Avellar et al, 2009;Burt et al, 1995;Mendes et al, 2004;Pacini et al, 2018;Pupo, 1998;Silva et al, 1999;Yono et al, 2012). Importantly, the contractions of the mouse and rat vas deferens in response to electrical field stimulation have been described to involve α 1Dadrenoceptors, and at least in the mouse vas deferens, these receptors seem to play a role in contractions to exogenous noradrenaline (Bexis et al, 2008;Cleary, Slattery, Bexis, & Docherty, 2004;Mallard, Marshall, Sithers, & Spriggs, 1992).…”
Section: α 1 -Adrenoceptors In the Heartmentioning
confidence: 99%
“…The presence of GR in smooth muscle cells surrounding the epididymal epithelium can be also correlated with neuromuscular events known to occur in this tissue. Contraction of epididymal smooth muscle cells are under the influence of androgens, autonomic neurotransmitters, and several other hormonal and nonhormonal factors, and are known to be required for the transport of spermatozoa through the tissue (Ricker, 1998; Avellar et al, 2009). Indeed, our group has recently detected a significant delay in sperm transit time in the caput/corpus epididymis of rats submitted to bilateral adrenalectomy (Silva et al, unpublished data).…”
Section: Expression and Function Of Glucocorticoid Receptor In The Epmentioning
confidence: 99%
“…Finally, it should be noted that muscarinic receptor agonists can induce proliferation in a number of prostate cancer cell lines (Witte et al ., 2008; Avellar et al ., 2009). Therefore, as well as inhibiting detrusor overactivity, muscarinic receptor antagonists may also relieve voiding symptoms of BPH by decreasing the size of the prostate and decreasing prostatic smooth muscle tone.…”
Section: Novel Targets: Muscarinic Receptor Antagonistsmentioning
confidence: 99%