Expression and function of lncRNA MALAT1 in gestational diabetes mellitus

Zhang, Yan; Qu, Liping; Ni, Huijie; Wang, Yuping; Li, Lei; Yang, Xiaowei; Wang, Xiao; Hou, Yuanyuan

doi:10.17219/acem/121524

Cited by 27 publications

(20 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, lncRNA MALAT1 expression was higher in placental tissues from a GDM group compared to a healthy pregnant women group ( 57 ). At a molecular level, the downregulation of lncRNA MALAT1 might inhibit the secretion of inflammatory factors and suppress the proliferation, invasion, and migration of GDM placental trophoblastic cells, possibly mediated by transforming growth factor (TGF)-β and NF-κB signaling pathways ( 57 ). In addition, compared to pregnant women without GDM, lncRNA MEG3 levels were also significantly elevated in the blood and placental villous tissues of those with GDM.…”

Section: Role Of Non-coding Rnas and Evs In Gdmmentioning

confidence: 98%

“…Recent studies have found that several specific lncRNAs were up-regulated in GDM and participated in regulatory processes (Table 1). For instance, lncRNA MALAT1 expression was higher in placental tissues from a GDM group compared to a healthy pregnant women group (57). At a molecular level, the downregulation of lncRNA MALAT1 might inhibit the secretion of inflammatory factors and suppress the proliferation, invasion, and migration of GDM placental trophoblastic cells, possibly mediated by transforming growth factor (TGF)-b and NF-kB signaling pathways (57).…”

Section: Role Of Lncrnas In Gdmmentioning

confidence: 99%

See 1 more Smart Citation

Non-Coding RNAs and Extracellular Vehicles: Their Role in the Pathogenesis of Gestational Diabetes Mellitus

et al. 2021

View full text Add to dashboard Cite

Gestational diabetes mellitus (GDM) is defined as glucose intolerance with onset or first recognition in the second or third trimester of pregnancy. GDM has a considerable impact on health outcomes of the mother and offspring during pregnancy, delivery, and beyond. Although the exact mechanism regarding GDM remains unclear, numerous studies have suggested that non-coding RNAs, including long non-coding (lnc)RNAs, microRNAs, and circular RNAs, were involved in the pathogenesis of GDM in which they played vital regulatory roles. Additionally, several studies have revealed that extracellular vehicles also participated in the pathogenesis of GDM, highlighting their important role in this disease. Considering the lack of effective biomarkers for the early identification of and specific treatment for GDM, non-coding RNAs and extracellular vehicles may be promising biomarkers and even targets for GDM therapies. This review provides an update on our understanding of the role of non-coding RNAs and extracellular vehicles in GDM. As our understanding of the function of lncRNAs and extracellular vehicles improves, the future appears promising for their use as potential biomarkers and treatment targets for GDM in clinical practice.

show abstract

Section: Role Of Non-coding Rnas and Evs In Gdmmentioning

confidence: 98%

Section: Role Of Lncrnas In Gdmmentioning

confidence: 99%

Non-Coding RNAs and Extracellular Vehicles: Their Role in the Pathogenesis of Gestational Diabetes Mellitus

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In particular, researchers are able to distinguish future GDM patients from healthy pregnant women through the plasma MEG8 levels one month before GDM diagnosis (43). Moreover, Zhang et al showed that the expression level of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in the case group is significantly higher than that of healthy pregnant women, suggesting that MALAT1 may also be a novel biomarker (44,45).…”

Section: Gene Expression and Transcriptional Productionmentioning

confidence: 99%

Mechanisms linking hyperglycemia in pregnancy to the offspring cardiovascular system dysfunction

et al. 2021

View full text Add to dashboard Cite

Hyperglycemia in pregnancy (HIP) is a high-glycemic state that occurs during pregnancy, and gestational diabetes mellitus (GDM) is the major cause of it. Studies reveal that GDM has long-term adverse impacts on mothers and offspring, such as maternal type 2 diabetes, premature birth and stillbirth in newborns, cardiovascular disease, and metabolic disorders in adult offspring. In recent years, studies on the transcription level of GDM and metabonomics have provided new insights into the pathophysiological mechanism of GDM. This article reviews the transcriptional levels and metabolomics studies involving GDM and cardiovascular dysfunction in the offspring, which may provide insight to the long-term health of pregnant women and offspring.

show abstract

“… 60 Zhang et al reported that MALAT1 is expressed at higher levels in GDM placentas (n = 78) compared to those of healthy controls (n = 38). 25 The lncRNA plasmacytoma variant translocation 1 (PVT1), located on chromosome 8q24.21, is a common retroviral integration site in murine leukemia virus (MLV)-induced T lymphomas. 61 It functions as an important oncogene owing to its facilitation of proliferation, invasion, and migration in tumor cells.…”

Section: Dysregulated Placental Ncrnas Are Associated With Gdmmentioning

confidence: 99%

“…However, the mechanism by which it modulates the TGF-β/NF-κB signaling pathway is unclear. 25 Suppression of PVT1 expression enhanced apoptosis and inhibited the proliferation, migration, and invasion of trophoblast cells. Moreover, significantly decreased Akt phosphorylation and the aberrant expression of CCND1, GDPD3, ITGAV, ITGB8, PDGFB , and EIF4EBP1 genes enriched in the PI3K/Akt pathway were observed after PVT1 knockdown, suggesting that PVT1 functions through the PI3K/Akt pathway.…”

Section: Function Of Placenta-specific Ncrnas In Gdmmentioning

confidence: 99%

Aberrantly Expressed Non-Coding RNAs in the Placenta and Their Role in the Pathophysiology of Gestational Diabetes Mellitus

Du¹,

Wu²,

L³

2021

DMSO

View full text Add to dashboard Cite

Expression and function of lncRNA MALAT1 in gestational diabetes mellitus

Cited by 27 publications

References 0 publications

Non-Coding RNAs and Extracellular Vehicles: Their Role in the Pathogenesis of Gestational Diabetes Mellitus

Non-Coding RNAs and Extracellular Vehicles: Their Role in the Pathogenesis of Gestational Diabetes Mellitus

Mechanisms linking hyperglycemia in pregnancy to the offspring cardiovascular system dysfunction

Aberrantly Expressed Non-Coding RNAs in the Placenta and Their Role in the Pathophysiology of Gestational Diabetes Mellitus

Contact Info

Product

Resources

About