Expression and functional activity of chemokine receptors in glatiramer acetate–specific T cells isolated from multiple sclerosis patient receiving the drug glatiramer acetate

Høglund, Rune Alexander; Hestvik, Anne Lise Karlsgot; Holmøy, Trygve; Maghazachi, Azzam A.

doi:10.1016/j.humimm.2010.10.016

Cited by 13 publications

(13 citation statements)

References 33 publications

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“…We observed that only four chemokine receptors warranted further study. These were CCR4, CCR5, CCR6 and CXCR3 [53] . The fact that all four clones from both peripheral blood and CSF expressed similar patterns of chemokine receptors could …”

Section: Role Of T Cellsmentioning

confidence: 99%

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Multiple sclerosis and the role of immune cells

Høglund

Maghazachi

2014

WJEM

135

101

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Multiple sclerosis (MS) is a complex disease with many different immune cells involved in its pathogenesis, and in particular T cells as the most recognized cell type. Recently, the innate immune system has also been researched for its effect on the disease. Hence, cells of the immune system play vital roles in either ameliorating or exacerbating the disease. The genetic and environmental factors, as well as the etiology and pathogenesis are of utmost importance for the development of MS. An insight into the roles play by T cells, B cells, natural killer cells, and dendritic cells in MS and the animal model experimental autoimmune encephalomyelitis, will be presented. Understanding the mechanisms of action for current therapeutic modalities should help developing new therapeutic tools to treat this disease and other autoimmune diseases.

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Section: Role Of T Cellsmentioning

confidence: 99%

“…Data adapted from Høglund et al [53] , Maghazachi [90] , Zlotnik et al [117] and Sallusto et al [118] . Høglund RA et al .…”

Section: Table 1 Chemokines Receptor Expression On T Cells and T Cellmentioning

confidence: 99%

Multiple sclerosis and the role of immune cells

Høglund

Maghazachi

2014

WJEM

135

101

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“…Interferon-β može da smanji ekspresiju hemokina i hemokinskih receptora karakterističnih za Th1 limfocite, kao što su CCL5, CCL3 i CXCR3, pri čemu se povećava ekspresija receptora tipičnog za Th2 limfocite, CCR4 (13,95). Glatiramer acetat je kopolimer sastavljen od aminokiselina koje se sa visokom efikasnošću vezuju za HLA klase II, a sa niskim afinitetom za receptore Th1 limfocita, prevodeći Th1 u Th2 ćelijski odgovor; pri tome rastu nivoi citokina koje produkuju Th2 limfociti, dok opadaju nivoi citokina koje sekretuju Th1 limfociti i ekspresija Th1-tipičnih hemokinskih receptora, CCR5 i CXCR3 (96,97).…”

Section: Uticaj Terapije Na Ekspresiju Hemokina I Hemokinskih Receptounclassified

Chemokines and chemokine receptors in the pathogenesis of multiple sclerosis

Stojković¹,

Živković²

2016

Medicinski casopis

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Multipla skleroza (MS) jeste kompleksna, hronična, inflamatorna i autoimunska bolest centralnog nervnog sistema (CNS) i jedan je od najčešćih uzročnika neurološkog deficita kod mladih odraslih osoba (1). Na osnovu kliničkog toka definisane su dve osnovne forme bolesti: relapsno-remitentna (bez sekundarno-progresivne faze ili sa njom) i primarno-progresivna (2). Ključni procesi prilikom nastanka i progresije MS jesu: inflamacija, demijelinizacija, neurodegeneracija i glioza u tkivu CNS (3). Usled narušavanja krvno-moždane barijere, leukociti periferne krvi prodiru kroz zid krvnih sudova u nervno tkivo i indukuju inflamaciju i demijelinizaciju (3). Na ovaj način nastaju plakovi koji predstavljaju akutne inflamatorne i demijelinizirajuće lezije u CNS i glavno histopatološko obeležje MS. Tokom vremena, plakovi evoluiraju i u njima intenzitet inflamacije opada, dok astrociti proliferišu stvarajući ožiljno tkivo. Različite molekularne komponente, kao što PREGLEDNI ČLANAK SAŽETAK Multipla skleroza (MS) jeste hronična inflamatorna i autoimunska, demijelinizirajuća bolest centralnog nervnog sistema (CNS). Migracija autoreaktivnih T-limfocita u tkivo ABSTRACT Multiple sclerosis (MS) is a chronic inflammatory and autoimmune, demyelinating disease of the central nervous system (CNS). Migration of autoreactive T lymphocytes into the CNS is one of the key processes that characterize the pathogenesis of MS and lead to the formation of inflammatory demyelinating CNS lesions. Chemokines represent a family of cytokines. They are low molecular weight soluble proteins, which affect target cells by binding to membrane chemokine receptors. Previous studies on experimental model of MS and experimental clinical studies confirmed that numerous chemokines and chemokine receptors, synthesized by CNS cells and various leukocyte populations, are an important component in the pathogenesis of MS. The essential role of chemokines in MS pathogenesis

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“…Diminished mean level of CXCR3 ligand CXCL10 was also observed in serum of MS patients after intravenous MP treatment [80]. Second, glatiramer acetate (GA), formerly known as copolymer 1, is widely used for treatment of MS via increasing the levels of Th2-related cytokines and CCR7 expression, decreasing Th1-related cytokines as well as the expression of CCR5, CXCR3, and CXCR6 on T cells [40, 76, 81–84]. Third, IFN- β has been proven as an effective drug for treatment of RRMS patients for many years [85–87].…”

Section: The Therapy Targeting Chemokines/chemokine Receptors Invomentioning

confidence: 99%

Chemokines and Chemokine Receptors in Multiple Sclerosis

Cheng

Chen

2014

Mediators of Inflammation

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Multiple sclerosis is an autoimmune disease with classical traits of demyelination, axonal damage, and neurodegeneration. The migration of autoimmune T cells and macrophages from blood to central nervous system as well as the destruction of blood brain barrier are thought to be the major processes in the development of this disease. Chemokines, which are small peptide mediators, can attract pathogenic cells to the sites of inflammation. Each helper T cell subset expresses different chemokine receptors so as to exert their different functions in the pathogenesis of MS. Recently published results have shown that the levels of some chemokines and chemokine receptors are increased in blood and cerebrospinal fluid of MS patients. This review describes the advanced researches on the role of chemokines and chemokine receptors in the development of MS and discusses the potential therapy of this disease targeting the chemokine network.

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Expression and functional activity of chemokine receptors in glatiramer acetate–specific T cells isolated from multiple sclerosis patient receiving the drug glatiramer acetate

Cited by 13 publications

References 33 publications

Multiple sclerosis and the role of immune cells

Multiple sclerosis and the role of immune cells

Chemokines and chemokine receptors in the pathogenesis of multiple sclerosis

Chemokines and Chemokine Receptors in Multiple Sclerosis

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