Expression and Functional Role of Reprogramming-Related Long Noncoding RNA (lincRNA-ROR) in Glioma

Feng, Shiyu; Yao, Jie; Yang, Chen; Geng, Peiliang; Zhang, Haibo; Ma, Xiaodong; Zhao, Jing; Yu, Xinguang

doi:10.1007/s12031-014-0488-z

Cited by 81 publications

(73 citation statements)

References 17 publications

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“…In general, lncRNA transcripts exhibit low-level but tissue-specific expression [27] and, with some exceptions [22], their nucleotide sequence is poorly conserved [28]. In the last few years, several studies have shown the importance of lncRNAs to normal physiology as well as to the control of gene expression, wherein they modulate key cellular processes such as cell proliferation, senescence, migration and apoptosis [29,30].…”

Section: The Non-coding Rna Landscapementioning

confidence: 99%

lncRNAs and microRNAs with a role in cancer development

Liz

Esteller

2016

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

476

349

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Most diseases, including human cancer, are frequently associated with an altered transcription pattern. The alteration of the transcriptome is not restricted to the production of aberrant levels of protein-coding RNAs, but also refers to the dysregulation of the expression of the multiple noncoding members that comprise the human genome. Unexpectedly, recent RNA-seq data of the human transcriptome have revealed that less than 2% of the genome encodes protein-coding transcripts, even though the vast majority of the genome is actively transcribed into non-coding RNAs (ncRNAs) under different conditions. In this review, we present an updated version of the mechanistic aspects of some long non-coding RNAs (lncRNAs) that play critical roles in human cancer. Most importantly, we focus on the interplay between lncRNAs and microRNAs, and the importance of such interactions during the tumorigenic process, providing new insight into the regulatory mechanisms underlying several ncRNA classes of importance in cancer, particularly transcribed ultraconserved regions (T-UCRs).

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Section: The Non-coding Rna Landscapementioning

confidence: 99%

lncRNAs and microRNAs with a role in cancer development

Liz

Esteller

2016

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

476

349

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“…1). Mostly, linc-ROR promotes the tumorigenesis, however, it can also be an inhibitor in the proliferation of cancer cells and self-renewal of glioma stem cells (GSCs), partly by blocking KLF4 expression [40].…”

Section: Functional Mechanisms Of Linc-rormentioning

confidence: 99%

“…In tumorigenesis, linc-ROR acts as an oncogene, except for one in glioma [40]. In general, linc-ROR is associated with diverse biological processes including proliferation, differentiation, apoptosis, invasion and metastasis in various human cancers (Table 1).…”

Section: Linc-ror-related Cancersmentioning

confidence: 99%

“…A series of studies has established the importance of linc-ROR as a marker of cancers. Marked upregulation of linc-ROR is observed in various cancers, including breast cancer [32][33][34], pancreatic cancer [48,70], hepatocellular cancer [36,37], endometrial cancer [38], and nasopharyngeal carcinoma [76], while linc-ROR acts as a tumor suppressor in glioma [40]. Although linc-ROR is overexpressed in various types of cancer, the target genes are rather variable depending on the host cell type.…”

Section: Linc-ror-related Cancersmentioning

confidence: 99%

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The Emerging Roles of Long Noncoding RNA ROR (lincRNA-ROR) and its Possible Mechanisms in Human Cancers

Pan

Li²,

Chen³

et al. 2016

Cell Physiol Biochem

120

100

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To date, there is only up to 2% of protein-coding genes that are stably transcribed, whereas the vast majority are non-coding RNAs (ncRNAs). These ncRNAs, also known as non-messenger RNAs (nmRNAs) or functional RNAs (fRNAs), include transfer RNAs, ribosomal RNAs, microRNAs and long non-coding RNAs (lncRNAs). With the advance of high-resolution microarrays and massively parallel sequencing technology, lncRNAs have gained extended attentions nowadays and are found to play important roles in tumorigenesis and progression of human cancers. Long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR), was first discovered in induced pluripotent stem cells (iPSCs), where it was controlled by the key pluripotency factors Oct4, Sox2 and Nanog. Linc-ROR has been shown to be dysregulated in many types of cancers, including breast cancer (BC), pancreatic cancer (PC), hepatocellular cancer (HCC), endometrial cancer (EC), and nasopharyngeal carcinoma (NPC). Also, linc-ROR functions as regulatory molecule in a large amount of biological processes. However, the underlying mechanisms of its contribution to carcinogenesis remain to be elucidated. In this review, we will emphasize on the characteristics of linc-ROR and their roles in different types of human cancers.

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“…lincRNA-RoR modulates reprograming and is indeed expressed at much higher levels in the embryonic stem cell line, H1-hESC, and human-induced pluripotent stem cells than in any other tissue or cell line [36,37]. Knockdown of lincRNA-RoR affects the expression of other stem cell factors such as KLF4, SOX2, and NANOG [38,39], resulting in an exit from the pluripotent state [37]. Together with vlincRNAs [25], HERV-driven lncRNAs can influence the transcriptome of the genes involved in pluripotency.…”

Section: Gene Regulation By Herv-driven Lncrnasmentioning

confidence: 99%

Influence of Endogenous Viral Sequences on Gene Expression

Sofuku¹,

Honda²

2018

Gene Expression and Regulation in Mammalian Cells - Transcription From General Aspects

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Endogenous viral elements (EVEs) are the heritable sequences present in eukaryotic genomes that have originated from viral nucleotide sequences. EVEs are subdivided into two groups, according to the presence or absence of long terminal repeats (LTRs). EVEs with LTRs are called endogenous retroviruses (ERVs), and they account for approximately 8% of the human genome. EVEs without LTRs seem to be related to non-reverse-transcribing RNA and DNA viruses, and recent studies have revealed that numerous vertebrate genomes contain these non-LTR EVEs. Such EVEs are proposed to play essential roles in gene expression. EVEs can regulate gene expression as cis-regulatory DNA and RNA elements. EVE-derived non-coding RNAs and/or proteins can also influence cell transcriptomes in trans. To maintain cell integrity, cells epigenetically silence the expression of most EVEs, making these elements generally biochemically inert. These epigenetic alterations around the EVE loci can also affect host transcriptomes. Here, we highlight the current knowledge available on the regulatory activities of ERVs and non-retroviral EVEs, especially the EVEs derived from bornaviruses, which are known as endogenous bornavirus-like elements (EBLs). Better knowledge of this area will improve our understanding of gene regulation and also the co-evolution of viruses and their hosts.

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Expression and Functional Role of Reprogramming-Related Long Noncoding RNA (lincRNA-ROR) in Glioma

Cited by 81 publications

References 17 publications

lncRNAs and microRNAs with a role in cancer development

lncRNAs and microRNAs with a role in cancer development

The Emerging Roles of Long Noncoding RNA ROR (lincRNA-ROR) and its Possible Mechanisms in Human Cancers

Influence of Endogenous Viral Sequences on Gene Expression

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