2003
DOI: 10.1016/s0167-0115(03)00192-7
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Expression and localization of AT1 receptors in hepatic Kupffer cells: its potential role in regulating a fibrogenic response

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Cited by 59 publications
(52 citation statements)
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“…For instance, ANGII stimulated mRNA expression of TGF-β and fibronectin can be reversed by saralasin and losartan, nonselective and specific antagonists for AT1R receptors, respectively (9).…”
Section: Introductionmentioning
confidence: 99%
“…For instance, ANGII stimulated mRNA expression of TGF-β and fibronectin can be reversed by saralasin and losartan, nonselective and specific antagonists for AT1R receptors, respectively (9).…”
Section: Introductionmentioning
confidence: 99%
“…13,14 Although the role other hepatic cells play in response to the AngII is less understood, Kupffer cells also have been shown to express the AT1 receptor under basal conditions. 15 Importantly, chronic systemic infusion of subpressor levels of AngII has been shown to cause a proinflammatory and profibrotic response in rat liver. 13 However, mechanisms by which the RAS may play a role in mediating hepatic inflammation remain unclear.…”
mentioning
confidence: 99%
“…It has also been shown that inhibition of the renin-angiotensin system (RAS) reduces the expression of TGF-␤1 and the extent of liver fibrosis both in animal models (24,35) and in humans with liver fibrosis (28), and that, conversely, stimulation of hepatic cells with ANG II increases the expression of TGF-␤1 (3,19). Thus the RAS may also play a pivotal role in the fibrosclerosis in the liver.…”
mentioning
confidence: 99%