Expression and localization of the uptake transporters OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue

Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy

“…Different studies report the expression of OATP5A1 in cancers (Table II). Immunohistochemical analyses confirmed that OATP5A1 is expressed on the membrane and in the cytoplasm of breast cancer cells (89). OATP5A1 at both the mRNA and protein levels was found to be upregulated in liver cancer (80) and small cell lung cancer (SCLC) (5).…”

“…OATP5A1 is reported to be expressed in the epithelial cells lining the mammary ducts (89). To date, the tissue distribution and substrates of OATP5A1 are poorly understood.…”

“…Higher OATP3A1 mRNA was detected in aneurysmal bone cysts as compared to osteosarcomas (65). In breast cancer, OATP3A1 is localized both on the plasma membrane and in the cytoplasm (89). Wleck et al showed that OATP3A1 levels were increased in primary and metastatic liver cancers (80).…”

Targeted Drug Delivery to Treat Pain and Cerebral Hypoxia

“…OATP3A1 is widely expressed at the mRNA level in several tissues including brain, testis, heart, lung, spleen, peripheral blood leukocytes, breast epithelial cells, and thyroid gland (Adachi et al, 2003;Huber et al, 2007;Banerjee et al, 2012;Obaidat et al, 2012). Recently, OATP3A1 protein expression was demonstrated in epithelial cells of the lactiferous ducts in physiologic breast tissue (Kindla et al, 2011) and in MCF10A cells (Banerjee et al, 2012). Interestingly, rat Oatp3a1 has been detected at the rat nasal mucosa, a drug delivery interface that is particularly intriguing (Genter et al, 2010).…”

“…Expression of OATP5A1 protein was recently reported at the plasma membrane of epithelial cells in lactiferous ducts isolated from normal breast tissue (Kindla et al, 2011). OATP6A1 mRNA Brain, testis, heart, lung, spleen, peripheral blood, leukocytes, thyroid, breast…”