Expression and prognostic value of platelet‐derived growth factor‐AA and its receptor α in nephroblastoma

Ghanem, Mazen A.; Nijman, Rien J.M.; Safan, Manal A; Kwast, Theodorus H. van der; Vansteenbrugge, Gert

doi:10.1111/j.1464-410x.2010.09211.x

Cited by 17 publications

(10 citation statements)

References 21 publications

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“…Moreover, an autocrine PDGF-BB/PDGF β-receptor loop was found to mediate survival of large granular lymphocyte leukemia of both T- and NK-cell origin (37). In addition, co-expression of PDGF-AA and PDGF α-receptor in the epithelial part of Wilms' tumor of the kidney is common; in contrast to other tumors with autocrine PDGF stimulation, the expression of PDGF-A and PDGF α-receptor in Wilms' tumor correlates to favorable prognosis (38). …”

Section: Autocrine Pdgf Stimulation In Human Glioma Osteosarcoma Anmentioning

confidence: 99%

Autocrine PDGF stimulation in malignancies

Heldin

2012

Upsala Journal of Medical Sciences

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Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of mesenchymal cells, which have important functions during the embryonal development and in the adult during wound healing and tissue homeostasis. In tumors, PDGF isoforms are often over-expressed and contribute to the growth of both normal and malignant cells. This review focuses on tumors expressing PDGF isoforms together with their tyrosine kinase receptors, thus resulting in autocrine stimulation of growth and survival. Patients with such tumors could benefit from treatment with inhibitors of either PDGF or PDGF receptors.

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Section: Autocrine Pdgf Stimulation In Human Glioma Osteosarcoma Anmentioning

confidence: 99%

Autocrine PDGF stimulation in malignancies

Heldin

2012

Upsala Journal of Medical Sciences

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“…In Wilms’ tumor of the kidney, PDGF-A and PDGFRα was expressed in 50% and 55% of the cases, respectively, in a cohort of 62 patients; interestingly, expression of PDGF-A and PDGFRα correlated with good prognosis [231]. It is possible that expression of PDGF-A and PDGFRα reflect a differentiated phenotype and therefore correlates to favorable prognosis.…”

Section: Introductionmentioning

confidence: 99%

Targeting the PDGF signaling pathway in tumor treatment

2013

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Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of certain cell types during embryonal development and e.g. tissue repair in the adult. Overactivity of PDGF receptor signaling, by overexpression or mutational events, may drive tumor cell growth. In addition, pericytes of the vasculature and fibroblasts and myofibroblasts of the stroma of solid tumors express PDGF receptors, and PDGF stimulation of such cells promotes tumorigenesis. Inhibition of PDGF receptor signaling has proven to useful for the treatment of patients with certain rare tumors. Whether treatment with PDGF/PDGF receptor antagonists will be beneficial for more common malignancies is the subject for ongoing studies.

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“…The potential diagnostic role of platelets in vascular diseases has been demonstrated in previous published reports (Berger et al, 2010; Chu et al, 2010; Muscari et al, 2009; Mutlu et al, 2013; Pyoa & Cho, 2016; Xia et al, 2015). The PLT and related PVI have been identified as biomarkers in various vascular diseases and malignant tumours (Berger et al, 2010; Ghanem, Nijman, Safan, van der Kwast, & van Steenbrugge, 2010; Muscari et al, 2009). Varicocele is a vascular disease with endothelial damage as the main pathophysiological basis (Tek et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

The predictive value of the platelet volume parameters in evaluation of varicocelectomy outcome in infertile patients

Ghanem

Adawi

Hakami³

et al. 2020

Andrologia

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The aim of this study was to evaluate the role of platelet count (PLT) and platelet volume indices (PVI) such as mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) as a clinical biomarker in 64 infertile males with varicocele and 45 controls. In addition, semen parameters, serum total testosterone, FSH and testicular volume were measured before and at 6 months after varicocelectomy. The mean PLT, MPV, PDW and PCT were 231 ± 42 × 103/µl, 9.6 ± 1.8 fl, 16.2 ± 2.5 fl and 0.18% in the patient group respectively. When the patient and control groups were compared, there was a significant increase in mean MPV, PDW and PCT (p < .0001), while platelet count was lower in patients than control group, but with no significant relationship. MPV had a significant negative correlation with total testosterone (p < .03). No significant correlations were found between PVI and testicular volume. After follow-up of 37.1 ± 1.9 months, a significant negative correlation was found between the preoperative MPV and varicocelectomy outcome in terms of semen values (p < .007). So, the increase in MPV and low total testosterone in men with varicocele may be a feature of high risk of infertility. K E Y W O R D Sinfertility, mean platelet volume, platelets count, semen parameters, varicocele 2 of 5 | GHANEM Et Al. | MATERIAL S AND ME THODS | Study sampleA total of 180 clinically diagnosed varicocele cases referred to our urology department with infertility. From this group, 64 patients with abnormal semen values underwent varicocelectomy. Forty-five infertile varicocele cases with normal semen values were randomly selected, included as control group, with a similar age between two groups. The protocol of this study followed the guidelines of the Declaration of Helsinki. Also, all the participants provided us a consent. | Selection criteriaPatient was initially included with the complaints of infertility and abnormal semen values by using WHO criteria (2010). Patients were included after excluding other genital diseases, exposure to gonadotoxins, sperm antibodies, endocrinological and internal diseases. In addition, patients with vascular problems (e.g., peripheral vascular disease, heart disease, thrombocytopenic purpura, thrombocytopenia, leukaemia and splenectomy) were excluded.The varicocele diagnosis was assigned by using the 1993 WHO guidelines. Patients with grade 1 varicocele were excluded from the study. The testicular volume was calculated by colour Doppler ultrasonography using Schiff formula (Schiff, Li, & Goldstein, 2004). | Laboratory analysisPeripheral venous samples were drawn into blood tubes containing ethylenediaminetetraacetic acid, early morning following an overnight fast, before varicocelectomy. All samples were analysed within 2 hr (Lance, Oerle, Henskens, & Marcus, 2010). The PLT and PVI (MPV, PDW and PCT) were measured using an automated blood cell analyser. Also, serum FSH, total testosterone levels and semen analysis were evaluated by using the procedure described by Mitchell et al. ...

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Expression and prognostic value of platelet‐derived growth factor‐AA and its receptor α in nephroblastoma

Cited by 17 publications

References 21 publications

Autocrine PDGF stimulation in malignancies

Autocrine PDGF stimulation in malignancies

Targeting the PDGF signaling pathway in tumor treatment

The predictive value of the platelet volume parameters in evaluation of varicocelectomy outcome in infertile patients

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