Expression, Distribution and Role of Aquaporins in Various Rhinologic Conditions

Abstract

Aquaporins (AQPs) are water-specific membrane channel proteins that regulate cellular and organismal water homeostasis. The nose, an organ with important respiratory and olfactory functions, is the first organ exposed to external stimuli. Nose-related topics such as allergic rhinitis (AR) and chronic rhinosinusitis (CRS) have been the subject of extensive research. These studies have reported that mechanisms that drive the development of multiple inflammatory diseases that occur in the nose and contribute to the process of olfactory recognition of compounds entering the nasal cavity involve the action of water channels such as AQPs. In this review, we provide a comprehensive overview of the relationship between AQPs and rhinologic conditions, focusing on the current state of knowledge and mechanisms that link AQPs and rhinologic conditions. Key conclusions include the following: (1) Various AQPs are expressed in both nasal mucosa and olfactory mucosa; (2) the expression of AQPs in these tissues is different in inflammatory diseases such as AR or CRS, as compared with that in normal tissues; (3) the expression of AQPs in CRS differs depending on the presence or absence of nasal polyps; and (4) the expression of AQPs in tissues associated with olfaction is different from that in the respiratory epithelium.

The Physical Chemistry and Chemical Physics (PCCP) Section of the International Journal of Molecular Sciences in Its Publications: The First 300 Thematic Articles in the First 3 Years

“…This thematic area is associated with articles [ 12 , 15 , 20 , 21 , 26 , 50 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 ], of which there are a total of 50. In contrast to the areas already discussed above, articles of all four types are presented here ( Table 5 ), although, here, too, the Original constitutes a clear majority over the other 3 types of articles.…”

“…In contrast to the areas already discussed above, articles of all four types are presented here ( Table 5 ), although, here, too, the Original constitutes a clear majority over the other 3 types of articles. The dominant feature of this thematic area was articles devoted to cell membranes, in general, and their electrochemistry, in particular; articles [ 26 , 50 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 92 , 93 , 95 , 99 , 100 ] are devoted to this specific topic. In this connection, it is worth noting that this “membrane topic” turned out to be, generally, the most popular in comparison with all the others presented in the PCCP Section of the IJMS , within the array of 300 articles we are considering.…”

A Functional Aqp1 Gene Product Localizes on The Contractile Vacuole Complex in Parameciummultimicronucleatum

“…“Orthodox AQPs” (AQP0, AQP1, AQP2, AQP4, AQP5, AQP6, and AQP8) are selectively permeable to water (Preston et al., 1994), while “Aquaglyceroporins” (AQP3, AQP7, AQP9, and AQP10) are permeable to uncharged small solutes such as glycerol (Fu et al., 2000), urea (Echevarria et al., 1994), ammonia (Holm et al., 2005), or even gases (Cooper and Boron, 1998), in addition to water. Finally, “Super‐aquaporins” (or Subcellular‐aquaporins) (AQP11 and AQP 12) have unique subcellular localization and their functions are under investigation (Itoh et al., 2005; Jung et al., 2020; Morishita et al., 2005). These channels are found throughout all domains of life (Gupta et al., 2012) and are fundamental elements in the osmoregulation of many organisms (Alleva et al., 2012).…”

Ion and Molecule Transport in Membrane Systems 2.0

“…The transport mechanisms in biomembrane systems are studied in [ 1 , 2 , 3 , 4 ]. The complicated transfer of keratinocyte toward the wound skin was studied by S. Hwang [ 1 ].…”

“…S.Y. Jung et al [ 4 ] made a review of the relationship between the properties of aquaporins (which are water-specific membrane channel proteins) and rhinologic disorders, such as nasal mucosa and olfactory mucosa, rhinosinusitis, and others.…”