2012
DOI: 10.1159/000332959
|View full text |Cite
|
Sign up to set email alerts
|

Expression of a Disintegrin and Metalloprotease in Human Abdominal Aortic Aneurysms

Abstract: Objectives: The a disintegrin and metalloprotease (ADAM) family of metalloproteases possesses a proteolytic function and activates various inflammatory factors. Their expression pattern in an abdominal aortic aneurysm (AAA) is as yet unknown. The aim of this study was to make a detailed analysis of the expression of ADAMs 8, 9, 10, 12, 15 and 17, and their tissue inhibitors of metalloprotease (TIMP)-1 and TIMP-3 in patients with AAA. Design: The aortic vessel walls of AAA patients (n = 20) and non-aneurysmal a… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
14
0
2

Year Published

2013
2013
2021
2021

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 17 publications
(17 citation statements)
references
References 53 publications
1
14
0
2
Order By: Relevance
“…The most studied family of matrix-degrading enzymes, which we also contributed to, is probably the matrix metalloproteinases (MMPs) since these proteases are capable to degrade plenty of macromolecules present in the connective tissue matrix [1–3]. The extensive family of matrix metalloproteases beside MMPs includes a disintegrin and metalloproteinase (ADAMs) of which several members have been found in tissue from abdominal aortic aneurysms (AAA) [4, 5]. …”
Section: Introductionmentioning
confidence: 99%
“…The most studied family of matrix-degrading enzymes, which we also contributed to, is probably the matrix metalloproteinases (MMPs) since these proteases are capable to degrade plenty of macromolecules present in the connective tissue matrix [1–3]. The extensive family of matrix metalloproteases beside MMPs includes a disintegrin and metalloproteinase (ADAMs) of which several members have been found in tissue from abdominal aortic aneurysms (AAA) [4, 5]. …”
Section: Introductionmentioning
confidence: 99%
“…ADAMs 8, 9, 10, 12, 15 and 17 were found to be expressed in both AAA and control aorta [19], and ADAM17 (TACE) was upregulated in human AAA aortic specimens and was associated with chronic inflammation, increased neoangiogenesis and ECM disruption [9]. The role that ADAM17 plays in the inflammation and proteolytic degradation of ECM in the vessel wall markedly contributes to the formation and rupture of an AAA [5,6].…”
Section: Discussionmentioning
confidence: 99%
“…Так, в формировании аневризмы аорты ведущую роль играет потеря эластина и коллагена, причиной чего служит повышение продукции различных типов протеаз, в том числе ММП-1, 2 и 9 [14,15]. При этом экспрессия тканевых ингибиторов матриксных металлопротеиназ (ТИМП-1 и ТИМП-2) понижена, что приводит к разрушению компонентов ВКМ стенки аневризмы [16,17]. Необходимым условием нормального протекания физиологических процессов является поддержание равновесия между активностью ММП и их ингибиторов.…”
Section: Expression Of Matrix Metalloproteinases and Their Inhibitorsunclassified
“…Вместе с тем, как показали результаты работ W. Wilson, E. Schwalbe (2005), а также C. Lipp и соавт. (2012), уровень ингибиторов металлопротеиназ ТИМП-1 и ТИМП-2 снижен в аневризмах брюшного отдела аорты по сравнению с нормальной аортой, что приводит к деградации компонентов ВКМ [16,17].…”
Section: результаты и обсуждениеunclassified