1994
DOI: 10.1016/0192-0561(94)90107-4
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Expression of a high-affinity serotonin transporter in human lymphocytes

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Cited by 102 publications
(69 citation statements)
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“…There is now some evidence that disorders in the central and peripheral metabolism of serotonin (5-HT) play a role in the pathophysiology of major depression and that antidepressant drugs exert their antidepressive effects through interactions with the serotonergic system (Maes and Meltzer 1995). T lymphocytes constitutively express 5-HT receptors, such as 5-HT1A and 5-HT2A/2C receptors, as well as high affinity 5-HT transporter, whereas macrophages possess a specific active 5-HT uptake system similar in affinity to that of platelets (Aune et al 1994;Jahnova 1994;Faraj et al 1994;Jackson et al 1988). After stimulation with polyclonal activators or IFN␥, monocytes and T lymphocytes release 5-HT (review: Aune et al 1994).…”
Section: Discussionmentioning
confidence: 99%
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“…There is now some evidence that disorders in the central and peripheral metabolism of serotonin (5-HT) play a role in the pathophysiology of major depression and that antidepressant drugs exert their antidepressive effects through interactions with the serotonergic system (Maes and Meltzer 1995). T lymphocytes constitutively express 5-HT receptors, such as 5-HT1A and 5-HT2A/2C receptors, as well as high affinity 5-HT transporter, whereas macrophages possess a specific active 5-HT uptake system similar in affinity to that of platelets (Aune et al 1994;Jahnova 1994;Faraj et al 1994;Jackson et al 1988). After stimulation with polyclonal activators or IFN␥, monocytes and T lymphocytes release 5-HT (review: Aune et al 1994).…”
Section: Discussionmentioning
confidence: 99%
“…After stimulation with polyclonal activators or IFN␥, monocytes and T lymphocytes release 5-HT (review: Aune et al 1994). The uptake of [ 3 H]-5-HT by lymphocytes is potently inhibited by antidepressants such as clomipramine, fluoxetine, and fluvoxamine (Faraj et al 1994). It has been shown that 5-HT has some negative immunoregulatory effects as indicated by the following: 5-HT decreases mitogen-induced T lymphoproliferative responses; 5-HT suppresses lymphocyte DNA synthesis; 5-HT inhibits the migration of mononuclear leukocytes; 5-HT inhibits T-cell activation of normal spleen cells; 5-HT decreases IFN␥-induced major histocompatibility antigen class II expression on macrophages; and 5-HT decreases the synthesis of TNF␣ by macrophages (Sternberg et al 1986;Bondesson et al 1993;Bonnet et al 1984;Kut et al 1992).…”
Section: Discussionmentioning
confidence: 99%
“…Serotonin transporters are reported to be expressed in primary B-lymphocytes, 41 T-lymphocytes, 41 and mixed lymphocyte populations. 44,41,45,46,21 However, others have failed to detect (or have detected only small amounts of) SERT in B-lymphocytes 33,34 and T-lymphocytes. 30 Human lymphoblastoid cell lines, which are Epstein−Barr virusimmortalized B-lymphocytes, are also thought to express functional SERT and have been used to study human SERT gene variants.…”
mentioning
confidence: 99%
“…Naoi et al 5) also showed that 5-HT inhibited the uptake of Trp-P-1 into PC12h cells, though they admitted that the involvement of the 5-HT transporter in the uptake of Trp-P-1 was still unclear because PC12h cells are a model of dopaminergic, but not serotonergic cells. However, a recent study 7) demonstrated that human lymphocytes have the 5-HT transporter. In this study, we showed that 5-HT (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…6) In addition, the transport systems of DA and 5-HT exist not only in synapses but also in platelets and lymphocytes. 7,8) Trp-P-1 was detectable in platelets for at least 9 days after oral administration to rabbits. 9) In this study, we investigated how Trp-P-1 is incorporated into splenocytes, thymocytes, and hepatocytes, and stimulates the apoptotic pathway.…”
mentioning
confidence: 99%