Expression of apoptotic and cell proliferation regulatory proteins in actinic cheilitis

Martínez, Alejandra; Brethauer, Ursula; Rojas, Isolde G.; Spencer, M. Loreto; Mucientes, Francisco; Borlando, J; Rudolph, M I

doi:10.1111/j.1600-0714.2004.00299.x

Cited by 30 publications

(27 citation statements)

References 36 publications

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“…Histologically, the superficial lamina propia presents extensive basophilic degeneration of collagen (Cavalcante et al, 2008;dos Santos et al, 2003;Markopoulos et al, 2004;Martinez et al, 2005;Rojas et al, 2004). Among other findings, the epithelial lining may display varying degrees of dysplasia ranging from a mild change to carcinoma in situ, and even invasive carcinoma (Araújo et al, 2010;Cavalcante et al;da Silva et al, 2007;Markopoulos et al;Xavier et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial Dysplasia

et al. 2012

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SUMMARY:The extracellular matrix (ECM) plays an important role in the regulation of biological events such as the development of cell migration, proliferation and differentiation. Chronic sun exposure causes changes present in the ECM of actinic cheilitis (AC), a premalignant lesion of the lower lip which helps to understand the carcinogenesis of the lip. This study aimed to investigate elastin, the main component of solar elastosis alternating current in an attempt to establish the relationship between this protein and ECM in epithelial dysplasia. Paraffin embedded tissue sections of the lesions of 35 cases of AC were analyzed by immunohistochemistry for elastin, and became the association with the degree of epithelial dysplasia and age. Highest scores of elastin (+3) was predominant in 45.7% of cases of AC, especially in cases of severe dysplasia (n = 3). When comparing the scores of elastin between the different grades of epithelial dysplasia showed no significant difference (P> 0.05, Kruskal-Wallis). This study was not able to demonstrate the influence of elastin on the severity of epithelial dysplasia in AC. Additional studies on other ECM proteins must be conducted in an attempt to better understand the mechanism of malignant progression of the AC.

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Section: Introductionmentioning

confidence: 99%

Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial Dysplasia

et al. 2012

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“…A hiperplasia epitelial pode ocorrer em até 100% das amostras de QA 30 , assim como a atrofia pode ocorrer com frequência relativamente alta 2,30 . Outras alterações epiteliais frequentemente observadas no presente estudo foram: degeneração hidrópica, hipergranulação e espongiose.…”

Section: Discussionunclassified

“…Alguns estudos apontam a elastose solar como um achado histopatológico constante e o mais consistente da QA 1,6,9,11,25,30 . A elastose solar reflete os danos solares ao tecido, podendo ser um importante fator no desenvolvimento da QA, sem, entretanto, ser preditivo para evolução da QA para CCE 15 .…”

Section: Discussionunclassified

Queilite actínica: avaliação histopatológica de 44 casos

Arnaud

Soares

Paiva

et al. 2014

Rev. odontol. UNESP

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ResumoObjetivo: Descrever os aspectos epidemiológicos, clínicos e histopatológicos da queilite actínica. Material e método: Foi realizado um estudo retrospectivo a partir de casos com diagnóstico clínico de queilite actínica, registrados no arquivo histopatológico do Serviço de Cirurgia de Cabeça e Pescoço do Hospital Napoleão Laureano, Paraíba, relativos ao período de 2000 a 2007. Foram selecionados 44 blocos parafinados, que apresentavam condições de reavaliação histológica através da confecção de novas lâminas. Os novos cortes foram corados em Hematoxilina e Eosina, e a avaliação histopatológica foi realizada por dois examinadores independentes, sendo as alterações classificadas de acordo com OMS. Realizou-se análise estatística descritiva em programa SPSS for Windows versão 13. Resultado: Do total da amostra, 52,3% (23) dos casos foram diagnosticados em homens e 47,7% (21) em mulheres, com idade variando de 27 a 92 anos. A maioria dos indivíduos (81,9%) tinha mais de 40 anos. Em relação às características histológicas, 68,2% (30) dos casos exibiram algum grau de displasia epitelial, sendo 36,3% (16) classificados como displasia leve, 20,4% (9) como displasia moderada e 11,3% (5), displasia severa. Em 15,9% (7), ocorreu carcinoma de células escamosas. No tecido epitelial de revestimento labial, os achados histológicos mais frequentes e identificados foram presença de degeneração hidrópica (79,5%) e hipergranulose (56,8%). Infiltrado inflamatório foi observado em 88,6% dos casos e elastose solar, em 86,4%. Conclusão: Com base nos resultados da amostra estudada, podemos concluir que a maioria das lesões de queilite actínica acometeu lábio inferior de homens, com mais de 40 anos de idade. A análise histopatológica revelou displasia e atipia celular, infiltrado inflamatório e presença de elastose solar, que são características comuns em lesões de QA.Descritores: Queilite; carcinoma de células escamosas; radiação solar; carcinogênese. AbstractObjective:To describe the epidemiological, clinical and histopathological aspects in actinic cheilitis. Material and method: We conducted a retrospective study from cases with clinical diagnosis of actinic cheilitis recorded in the histopathology of the Service of Head and Neck Napoleon Laureano Hospital, Paraíba, from 2000 to 2007. We selected 44 paraffin blocks to product new slides. These new sections were stained with hematoxylin and eosin, and histopathological evaluation was performed by two independent examiners, and the changes classified according to OMS. We conducted a descriptive statistical analysis in SPSS for Windows version 13. Result: Of the total sample, 52.3% (23) cases were diagnosed in men and 47.7% (21) in women aged from 27 to 92 years old. Most individuals (81.9%) were over 40 years old. Regarding the histologic features, 68.2% (30) of cases showed some degree of epithelial dysplasia, 36.3% (16) classified as mild dysplasia, 20.4% (9) moderate dysplasia and 11.3% (5) severe dysplasia. In 15.9% (7) cases, squamous cell carcinoma of lip was observed. In e...

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“…Research has been focused thus far on the evaluation of the immunohistochemical expression of the p53 protein [10]- [13]. Other immunohistochemical markers have also been used, including Bax, Bcl-2, the cell proliferation marker Ki-67 [12], MDM2 [10], p21 [11], p63 proteins [14], hMLH1 and hMSH2 [15]. Fibroblast and mast cell densities have also been studied, suggesting that these cells may contribute to the tumour progression in its invasion front [16] [17].…”

Section: Introductionmentioning

confidence: 99%

Actinic Cheilitis: Clinical Characteristics Observed in 75 Patients and a Summary of the Literature of This Often Neglected Premalignant Disorder

Miranda¹,

Ferrari²,

Leite³

et al. 2014

IJCM

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Actinic cheilitis can progress to squamous cell carcinoma in 20% of cases. The purpose of this study was to identify the clinical characteristics of 75 patients with actinic cheilitis and to summarise the current literature concerning actinic cheilitis. A total of 75 patients were evaluated over a 3-year period. The medical history, physical examination results and images were collected from each patient. Demographic data were collected and analysed. To review the literature, the relevant data were collected from scientific journals in the last 30 years. The mean age of the patients was 56 years old; 42 patients (56%) were female, and 66 patients (88%) were white. Nineteen (25.3%) patients reported at least one symptom, including pain, burning and itching. Sixty-five (86.7%) patients presented actinic cheilitis only in the lower lip. All of the patients reported sun exposure, and 44 (58.6%) patients were exposed for more than 10 years. The main clinical aspects investigated and analysed included dryness (100%), flaking (72%) and white lesions (57.3%). Lip assessment is extremely important in medical and dental care. From the 15 lesions assessed in the presence of actinic cheilitis, the most common clinical characteristics observed were dryness, flaking and white lesions. It is imperative to know the clinical aspects that may be encountered in actinic cheilitis in order to achieve early diagnosis, thus avoiding lip squamous cell carcinoma transformation.

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Expression of apoptotic and cell proliferation regulatory proteins in actinic cheilitis

Abstract: The results suggest that DNA-damaged cells by UV radiation in AC are eliminated by apoptosis.

Cited by 30 publications

References 36 publications

Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial Dysplasia

Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial Dysplasia

Queilite actínica: avaliação histopatológica de 44 casos

Actinic Cheilitis: Clinical Characteristics Observed in 75 Patients and a Summary of the Literature of This Often Neglected Premalignant Disorder

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